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  • 1
    Electronic Resource
    Electronic Resource
    The staphylococcal scalded skin syndrome (1977)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 96 (1977), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Histochemical and electron microscopic studies were carried out on the newborn mouse model of the staphylococcal scalded skin syndrome to investigate the mechanism of action of the staphylococcal epidermolytic toxin that causes it. Histochemical studies showed that an intra-epidermal split develops below the subcorneal zone which is rich in catabolic enzymes (the so-called esterase-acid phosphatase-rich band). However, histochemical alterations in the enzyme pattern could not be demonstrated. The earliest change revealed by electron microscopy was a widening of the intercellular space, with the formation of microvilli at the level between the stratum spinosum and stratum granulosum where the split later occurs. A clearing of the peripheral cytoplasm along the cell membranes was also revealed. In pre-split areas, adhesion between cell membranes of adjacent cells seems to be lost; desmosomes continue to hold the cells together but the split develops when these are broken by mechanical pressure. Later, damaged cell membranes may be seen. Extracellular keratinosomes remain unchanged.Although these findings do not agree with the already divergent results of other studies, they help support the findings of all groups that cases of the Lyell syndrome produced by staphylococci do not occur through necrolysis; it is therefore inappropriate to continue applying the term ‘toxic epidermal necrolysis’ to such cases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1977.tb07150.x
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  • 2
    Electronic Resource
    Electronic Resource
    The skin of the giraffe (1976)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 185 (1976), S. 63-75 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The skin of the giraffe has the same general histological structure as that of other mammals, but there are notable features. The skin is heavily pigmented with the epidermis, pilary canals, and the outer cell layer of the apocrine duct richly melanized. Furthermore, melanotic dendritic cells are frequently found in the sebaceous glands, the entire length of the external root sheath, and the secretory tubules of the apocrine glands. The thick skin has a papillary dermis that extends to just beneath the secretory coils of the apocrine glands and bulbs of hair follicles and an equally thick reticular layer below these structures. The hair follicles do not grow in clusters, and with some regional variations, have associated sebaceous glands, apocrine glands, and arrectores pilorum muscles. Only the large hairs have a prominent medulla. In such specialized regions as the eyelids, nose, and lips, the apocrine glands are surrounded by cholinesterase-reactive nerves but the glands on the general body surface are not. The only specialized nerve receptors are hair follicle end organs found on every hair of the eyelids, nose, and lips, but only rarely elsewhere.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091850106
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    Paper (German National Licenses)
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