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  • 1
    Electronic Resource
    Electronic Resource
    Development of celiac disease-associated antibodies in offspring of parents with Type I diabetes (2000)
    Springer
    Diabetologia 43 (2000), S. 1005-1011 
    Details
    ISSN: 1432-0428
    Keywords: Keywords Celiac disease ; Type I diabetes ; transglutaminase ; antibody screening ; islet antibodies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Aims/hypothesis. The aim of this study was to determine the frequency and temporal development of antibodies related to celiac disease in offspring of parents with Type I (insulin-dependent) diabetes mellitus. Methods. Sera from 913 offspring of parents with Type I diabetes prospectively followed from birth to the age of 8 years were tested for IgG-transglutaminase antibodies (IgG-tTGCAs), endomysial IgA antibodies (EMA) and gliadin antibodies. Results. We found tTGCAs in 32 (3.5 %) of the 913 relatives. Prevalence was related to age and reached 6.5 % at age 8 years. Endomysial IgA antibodies were detected in 44 % of the relatives with tTGCAs and 0.6 % of tTGCA negative relatives and were also most prevalent (5 %) in those aged 8 years. Both tTGCAs and EMAs were more frequent in relatives with the HLA DRB1*03 DQA1*0501 DQB1*02 haplotype (7.1 % and 7.2 %, respectively; p 〈 0.005). Anti-gliadin antibodies were common in both tTGCA positive (42 %) and negative (23 %) relatives, did not show a relation with age and were less prevalent in relatives with HLA DR3 (p 〈 0.05). There was no association between the presence of antibodies associated with celiac disease and islet autoantibodies in these relatives. Of the relatives 15 (1.6 %) had tTGCAs plus EMAs. In two of these, anti-gliadin antibodies were detected before the detection of tTGCAs and EMAs at the age of 9 months whereas none of the remainder had any antibodies associated with celiac disease before age 2 years. In three there were no detectable anti-gliadin antibodies in any of the samples tested. Celiac disease without clinical symptoms was diagnosed in 9 of 12 by intestinal biopsy. Conclusion/interpretation. A statistically significant proportion of relatives of patients with Type I diabetes have celiac disease-associated autoimmunity and the silent form of celiac disease early in life. These relatives should, therefore, be considered for celiac antibody screening. [Diabetologia (2000) 43: 1005–1011]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250051483
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  • 2
    Electronic Resource
    Electronic Resource
    The “Steakhouse syndrome” (1989)
    Springer
    Surgical endoscopy and other interventional techniques 3 (1989), S. 195-198 
    Details
    ISSN: 1432-2218
    Keywords: Food impaction of the esophagus ; Endoscopy ; Esophageal dysfunction ; Malignant tumors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Over a period of 5 years, 28 instances of acute food impaction of the esophagus were documented in 26 patients at our institution. In all patients the impacted bolus was successfully removed without complication using a flexible endoscope. Underlying diseases were identified during primary endoscopy in 31% of the cases. Further diagnostic workup was performed in all but 5 of the patients. After adequate evaluation pathologic findings were demonstrated in 90% of the cases (38% malignant and 52% benign diseases). Long-term therapy was deemed necessary in 17 of these 21 patients. Operative intervention was indicated in 4 cases, 2 of which were for malignant tumors. Acute food impaction should always be regarded as a symptom of esophageal disorders. In patients with esophageal cancer or other mediastinal tumors bolus impaction generally indicates an advanced tumor stage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02171545
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  • 3
    Electronic Resource
    Electronic Resource
    156. Das Omentum majus. Die Wiederentdeckung eines vergessenen Organes (1976)
    Springer
    Langenbeck's archives of surgery 342 (1976), S. 612-612 
    Details
    ISSN: 1435-2451
    Keywords: Omentum ; Embryology ; Immunology ; Transposition ; Surgery, plastic ; Omentum ; Embryologie ; Immunologie ; Transposition ; Plastische Chirurgie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Omentumtransposition ist inzwischen an verschiedenen Zentren mit Erfolg bei mehreren Hundert Patienten durchgeführt worden. Voraussetzung für diesen Eingriff ist die Kenntnis der Anatomie und Physiologie insbesondere der ausgeprägten immunologischen Aktivität des Omentums. Der Film geht deshalb zunächst auf embryologische Details, Histologie und Ultrastruktur ein, weist dann in der Gewebekultur die immunologische Kompetenz dieses Organs nach und demonstriert im Tierversuch die Omentumtransposition. An einer Patientin werden schließlich operative Details dieses Eingriffes dargestellt.
    Notes: Summary Omentum transposition has been successfully performed in various centers in hundreds of patients. This intervention requires an exact knowledge of anatomy and physiology and, above all, of the marked immunological activity of the omentum. This is why the film deals first of all with embryological details, histology and ultrastructure. Next it demonstrates the immunological competence of this organ in the tissue culture and shows omentum transposition in the animal experiment. Finally, the details of this surgical intervention are shown in a female patient.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01267504
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    Paper (German National Licenses)
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