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  • 1
    Electronic Resource
    Electronic Resource
    Brain microvessel hexokinase: Kinetic properties (1979)
    Springer
    Cellular and molecular life sciences 35 (1979), S. 169-171 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Kinetic differences between brain capillary and parenchymal hexokinase in the presence of glucose, ATP, fructose, potassium, sodium and different pH were established. Parenchymal hexokinase is more susceptible to glucose inhibition, can tolerate greater variations in the ATP concentration, is inhibited by increasing concentrations of fructose and potassium, and showed greater activity on the lower pH values. The data suggest that in brain parenchyma and endothelial cells of brain microvessels, there are 2 different enzymes with regard to the kinetic properties.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01920592
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Brain capillary guanosine triphosphatase: A distinction from adenosine triphosphatase (1980)
    Springer
    Cellular and molecular life sciences 36 (1980), S. 40-42 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Differences in kinetic properties, pH response, sensitivity to ouabain, and disc-acrylamide electrophoresis resolution, are observed when GTP and ATP are used as the substrates, for triphosphohydrolases in isolated rat brain microvessels. In brain parenchyma there are no such differences. It is concluded that substrate-specific GTPase exists in brain microvessels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02003958
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    The effect of physostigmine on (Na++K+)-ATPase activity in different rat brain regions (1980)
    Springer
    Cellular and molecular life sciences 36 (1980), S. 1348-1350 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The activity of (Na++K+)-ATPase and acetylcholine esterase were folloed in rat brain cerebral cortex, caudate, thalamus, hippocampus and medulla after i.v. administration of physostigmine. Both enzymes were found to be inhibited in a dose-dependent manner. The most pronounced inhibition of (Na++K+)-ATPase was found in caudate. where the highest activity of acetylcholine esterase is found.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01960090
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Regional distribution of lactate dehydrogenase isoenzymes in adult rat brain (1975)
    Springer
    Cellular and molecular life sciences 31 (1975), S. 1258-1260 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The highest lactate dehydrogenase (LDH) activity was found in thalamus, statistically significantly less in cerebral and cerebellar cortex and the lowest in pons. LDH1 and LDH4+5 represented 58% and 23% of the total activity in cerebral cortex, 54% and 20% in thalamus, 42% and 4% in cerebellar cortex and 55% and 7% in pons, respectively.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01945765
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Depression and parkinson's disease: possible role of serotonergic mechanisms (1987)
    Springer
    Journal of neurology 234 (1987), S. 94-96 
    Details
    ISSN: 1432-1459
    Keywords: Parkinson's disease ; Depression ; Human cerebrospinal fluid ; 5-Hydroxyindoleacetic acid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Depression is frequently encountered in Parkinson's disease and was seen to occur in 14 of 26 patients studied. The levels of 5-hydroxyindoleacetic acid (5-HIAA), the main metabolite of serotonin (5-HT), in CSF samples of the patients were significantly lower than in those of controls. However, within the group of patients the levels of 5-HIAA in CSF samples were significantly lower in the depressive subgroup compared with the non-depressive patients. Moreover, no correlation was recorded between motor disability and depression. The results indicate that disturbed 5-HT metabolism may possibly play a role in Parkinson's disease as a predisposing factor in the development of depression.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00314109
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Monoamines and related enzymes in cerebral cortex and basal ganglia following transient ischemia in gerbils (1980)
    Springer
    Acta neuropathologica 51 (1980), S. 71-77 
    Details
    ISSN: 1432-0533
    Keywords: Cerebral post-ischemia ; Gerbil ; Cerebral cortex ; Basal ganglia ; Monoamines ; Monoamine oxidase ; Catechol-O-methyl transferase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The post-ischemic effects on cerebral cortex and basal ganglia monoamine levels and monoamine oxidase (MAO A and B) and catechol-O-methyl transferase (COMT) activities were evaluated in Mongolian gerbils (Meriones unguiculatus) subjected to bilateral common carotid arteries occlusion for 15 min and reflow for 7 days. Disorders of monoamine metabolism was found in ischemic brain which persisted during the long-term post-ischemia. A rebound increase of norepinephrine and serotonin appeared in early stages (up to 1 h) of post-ischemia both in cerebral cortex and basal ganglia; a rebound increase of dopamine was found only in cerebral cortex. Thereafter, the serotonin level was enhanced over the control level during the whole post-ischemic period whereas the levels of catecholamines were reduced particularly in basal ganglia. With respect to monoamine content and activities of monoamine degraded enzymes an oscillatory behavior was observed in post-ischemia. Disorder of the monoamine metabolism found during post-ischemic period possibly contributes to neurological dysfunction after an ischemic insult.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688852
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Cerebral ischemia: Changes in monoamines are independent of energy metabolism (1989)
    Springer
    Neurochemical research 14 (1989), S. 1-7 
    Details
    ISSN: 1573-6903
    Keywords: Cerebral ischemia ; energy metabolism ; monoamines
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The relationship of neurotransmitters and neuroeffectors to the energy state of the brain was examined in the gerbil model of ischemia after 5 and 15 min of bilateral common carotid artery occlusion only or with 1 hr of reperfusion. The gerbil brains were fixed by microwave irradiation and a total of 15 metabolites were measured from a single piece of tissue from either the hippocampus or the striatum. The rapid alterations in energy-related compounds and cyclic nucleotides appeared to be directly related both to the loss of oxygen and glucose during ischemia and the resupply of these nutrients during reflow. Significant reduction in the level of monoamines occurred prinicipally during reflow, at a time when the energy-related metabolites were restored. It is proposed that the changes in monoamines were triggered by other ischemic-induced events unrelated to energy depletion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00969750
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    Paper (German National Licenses)
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