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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 64 (1995), S. 0 
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: The membrane metalloenzyme endopeptidase-24.11 has been localized by immunocytochemistry in the porcine hippocampus in the stratum oriens and stratum radiatum. Endopeptidase-24.11 was found to be ∼10-fold more abundant in a striatal than a hippocampal membrane preparation. Both somatostatin-28 and somatostatin-14 were metabolized by endopeptidase-24.11, but the kinetics of hydrolysis markedly favoured the smaller form of the neuropeptide. After phase separation with Triton X-114 of striatal and hippocampal membrane preparations, and by using selective inhibitors, the major (〉80%) somatostatin-metabolizing activity was found to partition into the detergent-rich phase and was attributable predominantly to endopeptidase-24.11. The residual activity observed in the presence of the selective endopeptidase-24.11 inhibitor phosphoramidon was blocked by Pro-Ile or N-[1-(RS)-carboxy-3-phenylpropyl]-Ala-Ala-Phe-p-aminobenzoate, inhibitors of endopeptidase-24.16 and endopeptidase-24.15, respectively. However, Pro-Ile, at comparable concentrations, was shown to inhibit endopeptidase-24.11, challenging the validity of its use as a selective inhibitor of endopeptidase-24.16. The immunocytochemical and Triton X-114 phase-separation data implicate endopeptidase-24.11, rather than endopeptidase-24.16 or endopeptidase-24.15, as the major physiological somatostatin-degrading neuropeptidase in the striatum and hippocampus.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Transportation 27 (2000), S. 75-97 
    ISSN: 1572-9435
    Keywords: activity scheduling ; computers ; respondent burden ; survey methods ; travel behaviour
    Source: Springer Online Journal Archives 1860-2000
    Topics: Architecture, Civil Engineering, Surveying
    Notes: Abstract Household activity scheduling is widely regarded as the underlying mechanism through which people respond to emerging travel demand management policies. Despite this, very little fundamental research has been conducted into the underlying scheduling process to improve our understanding and ability forecast travel. The experimental survey approach presented in this paper attempts to fill this gap. At the core of the survey is a Computerized Household Activity Scheduling (CHASE) software program. The program is unique in that it runs for a week long period during which time all adult household members login daily to record their scheduling decisions as they occur over time. An up-front interview is used to define a household's activity agenda and mode availability. A sample of 41 households (66 adults and 14 children) was used to assess the performance of the survey. Analysis focuses on times to completion, daily scheduling steps, activity-travel patterns, and scheduling time horizons. Overall, the results show that the computer-based survey design was successful in gathering an array of information on the underlying process, while minimizing the burden on respondents. The survey was also capable of tracing traditionally observed activity-travel outcomes over a multi-day period with minimal fatigue effects. The paper concludes with a detailed discussion on future survey design, including issues of instrument bias, use of the Internet, and improved tracing of spatial behaviour. Future use of the survey methodology to enhance activity-travel diary surveys and stated responses experiments is also discussed.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Transportation 24 (1997), S. 227-251 
    ISSN: 1572-9435
    Keywords: accidents ; graduated licensing ; policy ; road safety ; young drivers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Architecture, Civil Engineering, Surveying
    Notes: Abstract Despite improvements in road safety over the past several decades, accident rates remain high for young drivers. One accident countermeasure that is expected to improve the safety record of this group is graduated licensing. The philosophy behind this licensing system is that novice drivers, of whom the majority are young, should be restricted to relatively safe driving environments during the initial learning period. Graduated licensing was implemented in the Province of Ontario, Canada in 1994. The objective of this study is to estimate the potential benefits and costs for young drivers associated with two components of the Ontario graduated licensing package: the late-night driving curfew and the high-speed roadway restrictions. Based on accident and travel data for the year 1988, accident-involvement rates per kilometre driven were calculated for different driver groups for various combinations of time of day and roadway speed limit. These rates were then applied to the expected mobility profiles of young drivers affected by graduated licensing. The results of the study support the late-night curfew and suggest that this component of the licensing package should reduce total accident involvements for the affected group by up to 10 percent and fatal accident involvements by up to 24 percent, while reducing their total driving by only four percent. By contrast, the empirical evidence suggest that the high-speed roadway restrictions are likely to increase accident involvements, and thus it is strongly recommended that this component of Ontario's graduated licensing package be changed.
    Type of Medium: Electronic Resource
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