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  • 1
    Electronic Resource
    Electronic Resource
    observations in patients with a well-tolerated homotransplanted kidney: possibility of a new secondary disease (1965)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 120 (1965), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1965.tb30685.x
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  • 2
    Electronic Resource
    Electronic Resource
    OBSERVATIONS IN PATIENTS WITH A WELL-TOLERATED HOMOTRANSPLANTED KIDNEY: POSSIBILITY OF A NEW SECONDARY DISEASE (1964)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 120 (1964), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1964.tb34753.x
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  • 3
    Electronic Resource
    Electronic Resource
    KIDNEY HOMOTRANSPLANTATION IN MAN (1962)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 99 (1962), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1962.tb45364.x
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  • 4
    Electronic Resource
    Electronic Resource
    Macrophage Requirement for the in Vitro Response to an Insolubilized T-independent Antigen (1979)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 9 (1979), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The role of macrophages in the in vitro response of mouse spleen cells to the insolubilized, T-independent antigen trinitrophenylated polyacrylamide (TNP-PAA) is demonstrated by the following points. The response is abolished by filtration on Sephadex G-10 and can be restored by the addition of splenic adherent cells, deficient in either B or T cells, or by 2-mercaptoethanol (2-ME). It is suppressed upon elimination of phagocytic cells by silica, and restored by 2-ME. 2-ME can restore a normal response from zero, in cultures depleted of both adherent and phagocytic cells, and is efficient in the absence of mature T cells. Experiments in microcultures show that large numbers of macrophages can stimulate a supra-optimal response from B cells. This response is only obtained in the presence of the antigen, and is specific for TNP. These results show that macrophages, probably by their polyclonal B-cell activator (PBA) property, play a role in the specific response to TNP-PAA. This prompts us to discuss the respective roles in the B-cell response of this PBA activity and of the interaction of the antigen with the specific B-cell receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1979.tb02718.x
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  • 5
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Biochimie 67 (1985), S. XVIII 
    Details
    ISSN: 0300-9084
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0300-9084(85)80253-4
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  • 6
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Biochimie 67 (1985), S. XIX 
    Details
    ISSN: 0300-9084
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0300-9084(85)80254-6
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  • 7
    Electronic Resource
    Electronic Resource
    Effects of ventrolateral thalamic nucleus cooling on initiation of forelimb ballistic flexion movements by conditioned cats (1979)
    Springer
    Experimental brain research 34 (1979), S. 435-452 
    Details
    ISSN: 1432-1106
    Keywords: Cooling ; Ventrolateral thalamic nucleus ; Pyramidal system ; Reaction time ; Ballistic movement ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Five cats were trained to perform a forelimb ballistic flexion on a reaction time paradigm including an upper limit of about 400 ms for reinforcement (food pellets). They were implanted with a cyrogenic probe thermically insulated, except at the tip, by a vacuum jacket (outer diameter, 1.1 mm). Four cats had the probe inserted into the ventrolateral thalamic nucleus (VL), contralateral to the moving limb. During cooling they showed increased reaction times, which remained constant throughout daily sessions performed during many weeks, independent of the foreperiod but varying from 25 to 100 ms according to the subject. The temperatures used to upset the reaction times varied from +10 ° C to −8 ° C, depending on the localisation of the probe and on the insulation of the silver tip used to prevent nervous tissue reaction, but for each subject the reaction times always increased when the temperature was lowered. The fifth cat, with a probe inserted between VL and the Centre Median, showed a decrease of reaction times on cooling to 0 ° C and an increase of the reaction times for a cooling at −10 ° C. For one of the four cats with a probe properly inserted into the VL, strain-gauges were stuck on the lever to measure the latency of the decrease of the pressure exerted by the subject when the subject initiated the forelimb flexion in response to the CS. Reaction times and latencies of pressure changes were closely correlated with the movement onset, and they were equally delayed during cooling. This result demonstrates that it is not by slowing down movement velocity that reaction times are upset during VL cooling but by delaying the movement onset.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00239141
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  • 8
    Electronic Resource
    Electronic Resource
    Acute cyanide poisoning: Recovery with non-specific supportive therapy (1983)
    Springer
    Intensive care medicine 9 (1983), S. 33-35 
    Details
    ISSN: 1432-1238
    Keywords: Cyanide poisoning ; Non-specific supportive therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Potassium cyanide overdosage occurred in a 43-year-old man resulting in convulsions, cardiac arrest, massive lactic acidosis and rhabdomyolysis. Perfect recovery was obtained with only non-specific supportive therapy (100% oxygen ventilation, vascular volume expansion, sodium bicarbonate infusion, anticonvulsivant drugs).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01693704
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  • 9
    Electronic Resource
    Electronic Resource
    Hyperchloremic acidosis during grand mal seizure lactic acidosis (1994)
    Springer
    Intensive care medicine 20 (1994), S. 27-31 
    Details
    ISSN: 1432-1238
    Keywords: Lactic acidosis ; Convulsions ; Hyperchloremic acidosis ; Distribution spaces
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective To evaluate the prevalence and the mechanism of hyperchloremic acidosis component (HC1A) during lactic acidosis secondary to grand mal seizures. Design Retrospective study. Setting Medical intensive care unit in a university hospital. Patients 35 patients admitted for grand mal seizures with lactic acidosis (pH〈7.35, TCO2 〈20 mmol/l and PaCO2 〈8 kPa). Measurements HC1A was defined by the ratio: excess anion gap/HCO3 deficit (ΔAG/ΔTCO2) 〈0.8. A difference in the distribution space of protons and their accompanying anion, i.e., a displacement of chloride from cells by the entering lactate, was evaluated by the ratio natremia/chloremia (Na+/Cl−). Results Immediately after seizures, a profound lactic acidosis was observed (pH=7.22±0.17 (mean±SD), AG: 23.8±7.1 mmol/l, TCO2=14.5±5.3 mmol/l, lactate: 14.6±6.9 mmol/. HC1A was present on admission in 11 patients (31.5%). Its prevalance increased to 73% after recovery. ΔAG/ΔTCO2 ratios were unrelated to creatinine, level and PaCO2, but dependent on the ratio Na+/Cl− (r=0.803;p〈0.001, ΔAG/ΔTCO2=6.4 X (Na+/Cl−)−7.9). These data demonstrate that HC1A is not a respiratory or renal phenomenon and suggest differences in the distribution spaces of hydrogen ions and their accompanying anions. Conclusion HC1A component may be associated with lactic acidosis in grand mal seizures and appears to be secondary to a lactate antiport. This phenomenon could be an immediate physiological response to a sudden metabolic acidosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02425050
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  • 10
    Electronic Resource
    Electronic Resource
    Motor command in the ventrolateral thalamic nucleus: Neuronal variability can be overcome by ensemble average (1982)
    Springer
    Experimental brain research 48 (1982), S. 315-322 
    Details
    ISSN: 1432-1106
    Keywords: Ventrolateral thalamic nucleus ; Variability ; Stationarity ; Motor program ; Information processing
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The variability and stationarity of single unit activity and reaction times in a simple reaction time task were investigated by means of unit recordings from the ventrolateral thalamic nucleus in the cat. The study was carried out on eight neurons recorded over many trials and displaying an increase in activity correlated with the performed reaction time. The stationarity of the correlation appeared to be better than that of the unit activity or reaction time taken alone. In this stationary process the neuronal variability is considerable, and the investigator has to use time averages over many trials to be able to extract information from the single unit data. Since the nervous system does not require repeated presentations of a stimulus to trigger a movement, it must be using parallel processing of information through ensemble averages. A simulation of an ensemble average based upon the data from these eight neurons showed that such a process can be efficient. An evaluation of the number of neurons required to obtain a quasi deterministic neuronal command of the reaction time value, gave the speculative figure of 70. This figure could represent the dimension of the set of neurons with the same characteristics involved in the motor command.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00238606
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