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  • 1
    ISSN: 1398-9995
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Background:  Little is known about the natural course of persistent rhinitis symptoms over a prolonged period.Objective:  To describe the frequency and severity of nasal symptoms and quality of life (QoL) in house dust mite-sensitive persistent rhinitic subjects and to determine if medication use was related to symptoms.Methods:  Rhinitics and controls were telephoned fortnightly for 1 year to monitor symptoms. QoL was measured every 3 months.Results:  Thirty-seven rhinitics and 19 controls completed the study. Total nasal symptom scores (TNSS) were ‘high’ for 65% (95% CI ± 6%) of the year in rhinitic subjects. When TNSS increased by 1, the likelihood of nasal medication use increased by 25% (95% CI: 7–46%). General and specific QoL were worse in rhinitic subjects than controls (P 〈 0.04 and 〈0.0001). Rhinitics with pollen allergy (n = 21) had seasonal variation in the frequency of high nasal symptom scores (P = 0.02).Conclusion:  Nasal symptom scores were consistently high in rhinitics, and their QoL was worse than controls, even in general QoL. An increase in nasal symptom score increased the likelihood of nasal medication use. These findings help to characterize the course of persistent rhinitis over a previously unstudied period of 1 year.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    ISSN: 1398-9995
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Background:  The association between nasal and bronchial symptoms, and the course of bronchial responsiveness and airway inflammation in house dust mite sensitive persistent rhinitis over a prolonged time period has not been thoroughly explored.Objective:  To determine if nasal symptoms were associated with bronchial symptoms in persistent rhinitic subjects, and to assess their bronchial responsiveness and airway inflammation in comparison to nonrhinitic, nonatopic controls. The additional impact of pollen sensitivity on the lower airways in rhinitic subjects was also addressed.Methods:  Rhinitics and controls answered telephone symptom questionnaires once every 2 weeks for 1 year. Every 3 months, exhaled nitric oxide (eNO) and bronchial responsiveness to histamine were measured.Results:  Thirty-seven rhinitics and 19 controls completed the study. High nasal symptom scores in rhinitic subjects were associated with bronchial symptoms (OR = 1.7, 95% CI 1.2–2.5). Bronchial hyper-responsiveness was present in 32.4% of rhinitic subjects on at least one clinical visit during the year. Pollen allergy caused seasonal variation in eNO (P = 0.03).Conclusion:  In persistent rhinitic subjects, high nasal symptom scores were associated with bronchial symptoms, and many subjects experienced bronchial hyper-responsiveness during the year. Persistent rhinitic subjects were more at risk than healthy adults of bronchial symptoms and airway inflammation, which are likely risk factors for asthma.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    ISSN: 1615-6110
    Schlagwort(e): Caucalideae ; Scandiceae ; Apiaceae ; Umbelliferae ; chloroplast DNA restriction sites ; rps16 intron
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract Evolutionary relationships among members of Apiaceae (Umbelliferae) tribe Caucalideae Spreng. and related taxa were inferred from maximum parsimony analyses of chloroplast DNA restriction sites andrps16 intron sequences and the results compared to an existing phylogeny for the group based on nuclear ribosomal DNA internal transcribed spacer sequences. While these three data sets were not similar in size or composition, the relationships among the shared taxa, with few exceptions, were concordant. Three major lineages are recognized, coinciding with the previously delimited Scandiceae subtribes Daucinae Dumort. (Agrocharis, Ammodaucus, Cuminum, Daucus, Orlaya, Pachyctenium, Pseudorlaya), Torilidinae Dumort. (Astrodaucus, Caucalis, Glochidotheca, Lisaea, Szovitsia, Torilis, Turgenia, Yabea), and Scandicinae Tausch (Anthriscus, Kozlovia, Myrrhis, Osmorhiza, Scandix). Included in Daucinae is representation from tribe Laserpitieae (Laser, Laserpitium, Melanoselinum, Monizia, Polylophium). Daucinae and Torilidinae arise as sister taxa in the chloroplast DNA-based phylogenies, whereas in the ITS trees relationships among the three major lineages are unresolved. Unexpectedly, three species ofFerula ally with Daucinae and Torilidinae. The position ofArtedia is equivocal, occurring either sister to Daucinae in the ITS trees, within Torilidinae in the intron trees, or sister to Torilidinae upon analysis of combined ITS and intron data.Chaetosciadium trichospermum emerges withinTorilis, and is recognized asTorilis trichosperma (L.) Spreng.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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