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  • 1
    Electronic Resource
    Electronic Resource
    Surface-grafted Cell-binding Peptides in Tissue Engineering of the Vascular Graft (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 665 (1992), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1992.tb42589.x
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  • 2
    Electronic Resource
    Electronic Resource
    Endothelial Cell-Selective Materials for Tissue Engineering in the Vascular Graft Via a New Receptor (1991)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 9 (1991), S. 568-572 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] We have found a novel adhesion receptor on the human endothelial cell for the peptide sequence Arg-Glu-Asp-Val (REDV), which is present in the III-CS domain of human plasma fibronectin, with a dissociation constant of 2.2 × 10−6 M and 5.8 × 106 sites/cell. When a synthetic peptide ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt0691-568
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  • 3
    Electronic Resource
    Electronic Resource
    Phase-mixed poly(ethylene glycol)/poly(trimethylolpropane triacrylate) semi-interpenetrating polymer networks obtained by rapid network formation (1994)
    Bognor Regis [u.a.] : Wiley-Blackwell
    Journal of Polymer Science Part A: Polymer Chemistry 32 (1994), S. 2715-2725 
    Details
    ISSN: 0887-624X
    Keywords: semi-IPN ; PEG ; TMPTA ; phase separation ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Semi-interpenetrating polymer networks (semi-IPNs) of poly(ethylene glycol) (PEG) in poly(trimethylolpropane triacrylate) (TMPTA) were synthesized from PEG melts in neat TMPTA monomer, using PEG of molecular weights from 4000 to 100,000 g/mol. Differential scanning calorimetry and transmission electron microscopy were used to examine phase separation occurring during network formation. The degree of phase separation was observed to depend upon the rate of PEG aggregation relative to the rate of network formation during TMPTA polymerization. Higher molecular weight PEG and acrylate-functionalized PEG formed more phase-mixed networks compared to lower molecular weight PEG; acetatefunctionalized PEG showed no difference from unmodified PEG in the extent of phase mixing. For networks that demonstrated phase separation, the PEG was observed to be in two states: some being phase mixed and solvent inextractable, and some being phase separated and solvent extractable. Phase-mixed networks could be obtained from this thermodynamically incompatible polymer pair utilizing rapid photopolymerization systems to overcome PEG phase aggregation and kinetically entrap the PEG in a nonequilibrium phase-mixed state. These mixed-phase semi-IPNs of PEG and TMPTA may be useful in biological applications where the presence of PEG is desired throughout the bulk matrix rather than as a surface graft to reduce biological interactions. © 1994 John Wiley & Sons, Inc.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pola.1994.080321412
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  • 4
    Electronic Resource
    Electronic Resource
    Multifunctional poly(ethylene glycol) semi-interpenetrating polymer networks as highly selective adhesive substrates for bioadhesive peptide grafting (1994)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 43 (1994), S. 772-780 
    Details
    ISSN: 0006-3592
    Keywords: bioadhesion ; peptides ; poly(ethylene glycol) ; polymer networks ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Novel artificial extracellular matrices were synthesized in the form of semi-interpenetrating polymer networks containing copolymers of poly(ethylene glycol) and acrylic acid (PEG-co-AA) grafted with synthetic bioadhesive peptides onto exposed carboxylic acid moieties. These substrates were very resistant to cell adhesion, but when they were grafted with adhesive peptides they were highly biospecific in their ability to support cell adhesion. Extensive preadsorption of adhesive proteins or peptides did not render these materials cell adhesive; yet covalent grafting of adhesive peptides did render these materials highly cell adhesive even in the absence of serum proteins. Polymer networks containing immobilized PEG-co-AA were grafted with peptides at densities of 475 ± 40 pmol/cm2. Polymer networks containing immobilized PEG-co-AA N-terminally grafted with GRGDS supported cell adhesion efficiencies of 42 ± 4% 4 h after seeding and became confluent after 12 h. These cells displayed cell spreading and cytoskeletal grafted with inactive control peptides (GRDGS, GRGES, or no peptide) supported cell adhesion efficiencies of 0 ± 0%, even when challenged with high seeding densities (to 100,000 cell/cm2) over 14 days. These polymer networks are suitable substrates to investigate in vitro cell-surface interactions in the presence of serum proteins without nonspecific protein adsorption adhesion signals other than those immobilized for study.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260430812
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  • 5
    Electronic Resource
    Electronic Resource
    Densely crosslinked polymer networks of poly(ethylene glycol) in trimethylolpropane triacrylate for cell-adhesion-resistant surfaces (1995)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 29 (1995), S. 207-215 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Densely crosslinked semi-interpenetrating polymer networks (semi-IPNs) of poly(ethylene glycol) (PEG) were synthesized by photopolymerizing a melt of PEG of various molecular weights and end-group functionalities in neat trimethylolpropane triacrylate (TMPTA). Increasing the molecular weight of PEG in the matrix from 1000 to 100,000 g/mol reduced the advancing and receding contact angles, contact angle hysteresis, and adsorption of human fibrinogen and bovine serum albumin. Crosslinked TMPTA homonetworks supported human fibroblast adhesion in vitro, whereas the resistance to cell adhesion of the semi-IPNs depended upon PEG molecular weight: Lower molecular weight PEG reduced the number of adherent cells; higher molecular weight PEG further reduced and eliminated cell adhesion, as did networks containing acrylate-functionalized PEG. A polymer system incorporated with PEG throughout a hydrophobic, densely crosslinked matrix, rather than as a blend or surface treatment, may be particularly useful for limiting biologic interactions when bulk material properties must be independent of the solvent environment and where surface abrasion may occur. © 1995 John Wiley & Sons, Inc.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820290211
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