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  • 1
    Electronic Resource
    Electronic Resource
    Mechanism of action of suprofen, a new peripheral analgesic, as demonstrated by its effects on several nociceptive mediators
    Amsterdam : Elsevier
    Prostaglandins 28 (1984), S. 241-252 
    Details
    ISSN: 0090-6980
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0090-6980(84)90060-1
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Bromperidol, a new butyrophenone neuroleptic: A review (1982)
    Springer
    Psychopharmacology 78 (1982), S. 1-7 
    Details
    ISSN: 1432-2072
    Keywords: Bromperidol ; Haloperidol ; Chlorpromazine ; Preclinical review ; Animal pharmacology ; Animal pharmacokinetics ; Animal biotransformation ; Animal drug safety
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This review compares and contrasts the preclinical pharmacology of bromperidol with another butyrophenone neuroleptic, haloperidol, and the phenothiazine neuroleptic chlorpromazine. Its pharmacokinetics, biotransformation, and safety in several laboratory animal species are also summarized. These preclinical data support its use as an antipsychotic agent and show that it is well absorbed following oral administration with an apparent elimination half-life of approximately 24 h, supporting a once-daily dose regimen. Animal toxicity (including acute- and multiple-dose toxicology and reproductive and mutagenicity studies) show that bromperidol is well tolerated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00470578
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    The antialgesic drugs: Human therapeutic correlates of their potency in laboratory animal models of hyperalgesia (1987)
    Springer
    Inflammation research 20 (1987), S. 50-60 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This survey discusses the correlation between the oral potency of antialgesic drugs in several pharmacology laboratories and their human oral dose in clinical practice. We also present a brief overview of a few biological assays that have been successfully used to direct the synthesis of newer antialgesic drugs. The laboratory assay that our analysis showed to be most predictive of the clinical analgesic dose is based upon the response of rats to flexion of an arthritic joint. Laboratory ED50 values from the ACh-induced abdominal constriction assay in mice are nearly as predictive while the predictive power of the yeast-induced hyperalgesia assay in rats is somewhat less. Probably because of the small number of experiments, the correlation between the efficacy of these agents in a canine model of synovitis and their clinical doses only reached borderline statistical significance (p=0.0651). Regression equations are presented that permit calculations of single clinical analgesic doses from efficacy data in individual tests. Calculation of stepwise multiple regression showed that the clinical dose could be best predicted when efficacy data obtained in the joint flexion assay in rats and the ACh-induced constriction assay in mice are both taken into account. We have concluded that the effective doses are highly predictive of clinical efficacy because these animal assays have been designed to reflect the action of drugs upon prostanoid-induced hyperalgesia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01965625
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Effects of Δ9-Tetrahydrocannabinol (THC) and chlordiazepoxide (CDP) on state-dependent learning: evidence for asymmetrical dissociation (1973)
    Springer
    Psychopharmacology 30 (1973), S. 173-184 
    Details
    ISSN: 1432-2072
    Keywords: δ 9-Tetrahydrocannabinol ; Chlordiazepoxide ; Acquisition Learning ; State-Dependent Learning
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract δ 9-Tetrahydrocannabinol (THC) and chlordiazepoxide (CDP) were studied for their effects upon acquisition, performance, state-dependent learning and reciprocal substitution in mice. Over a wide dose range, CDP had no effect while THC had a biphasic effect (depression at low doses and facilitation at high doses) on avoidance acquisition. Both agents elicited evidence for state-dependent learning; mice trained under drugged conditions failed to transfer learning to the non-drugged state. In contrast, performance decrements occurred only after high doses (40 mg/kg) of each were given to avoidance trained mice. Administration of CDP facilitated avoidance performance in drug naive mice after doses of 1.25 mg/kg and above. THC failed to prevent learning deficits in CDP-trained subjects. In contrast, CDP prevented avoidance deficits after doses of 5 mg/kg and above in THC-trained subjects. These results suggest that an asymmetrical dissociation exists between THC and CDP or between either agent and saline.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00421432
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    A comparative study of the behavioral effects of scopolamine and 4-(1-naphthylvinyl) pyridine hydrochloride (NVP), an inhibitor of choline acetyltransferase (1972)
    Springer
    Psychopharmacology 23 (1972), S. 34-47 
    Details
    ISSN: 1432-2072
    Keywords: Choline Acetyltransferase Inhibitor ; Scopolamine ; Psycho-pharmacology ; Potentiation ; Drug Metabolism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A selective inhibitor of choline acetyltransferase, 4-(1-naphthylvinyl) pyridine hydrochloride (NVP), was compared with a central cholinergic antagonist, scopolamine, in a number of behavioral procedures in rats. Scopolamine (1 mg/kg, i.p.) caused alterations in performance of animals trained on nondiscriminated avoidance, punishment discrimination and conditioned suppression behavior, and had no effect on discrete avoidance behavior after doses as high as 8 mg/kg. After nonataxic doses (10–50 mg/kg, i.p.), NVP had no inhibitory effects in these behavioral schedules, and only after higher doses (100–200 mg/kg, i.p.) was an inhibitory effect on discrete avoidance obtained. It is suggested that less than complete inhibition of choline acetyltransferase does not provide sufficient attenuation of central cholinergic function to mimic the behavioral effects of a cholinergic antagonist. NVP was found to potentiate the pharmacological effects of chlorpromazine and physostigmine, suggesting an inhibitory action on drug metabolizing enzymes; it also had a protective effect upon maximal electroshock seizures in mice.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00414412
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    Paper (German National Licenses)
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