ISSN:
0009-2940
Keywords:
Catecholamide
;
Protochelin
;
Ligand-promoted dissolution
;
Iron
;
Siderophores
;
Chemistry
;
Inorganic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Protochelin, the tris(catecholamide) siderophore recently identified in the culture medium of A. vinelandii, can be synthesised by coupling of suitably protected azotochelin and aminochelin derivatives in preparative yields, Based on the ligand protonation constants of pK1 = 6.67, pK2 = 8.09 and pK3 = 9.68, the proton-independent stability constant for ferric protochelin could be estimated to be 1044.6. The solubilisation of FeIII hydroxide by protochelin has been investigated spectrophotometrically in aqueous solution at pH = 7. Since the production of protochelin by A. vinelandii depends on high molybdate levels in the growth medium, the studies have been carried out in the presence as well as in the absence of an equimolar amount of molybdate. Although the protochelin promoted dissolution of FeIII hydroxide is delayed significantly in presence of molybdate, the effect is far less pronounced than the one observed for azotochelin, the bis(catecholamide) siderophore of A. vinelandii.
Additional Material:
4 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/cber.19971300726
Permalink
