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  • 1
    Electronic Resource
    Electronic Resource
    Differential Roles of Raphe Nuclei in the Regulation of Dopamine β-Hydroxylase in the Adrenal Gland of the Rat (1986)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 46 (1986), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: The effect of reserpine on the activity of dopamine β-hydroxylase (DBH) in the adrenal gland of the rat was determined following electrolytic lesion of the dorsal raphe nucleus (DRN) or medial raphe nucleus (MRN). In sham-operated rats, as well as in those with a lesion of the DRN, there was no significant modification of the action of reserpine on this enzyme. However, a lesion of MRN potentiated the inducing action of the drug. A specific role of MRN in the serotonergic regulation of adrenal DBH is suggested by this work.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1986.tb12968.x
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  • 2
    Electronic Resource
    Electronic Resource
    ACTIVITY OF ALDEHYDE DEHYDROGENASE, ALDEHYDE REDUCTASE, AND ACETYLCHOLINE ESTERASE IN STRITATUM OF RATS BEARING ELECTROLYTIC LESIONS OF THE MEDIAL FOREBRAIN BUNDLE (1975)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 24 (1975), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A number of enzymes have been measured in the striatum of rats in which the dopamine-containing nerve terminals had been unilaterally destroyed by means of unipolar electrolytic lesions of the medial fore-brain bundle. Fourteen and 28 days after such lesions the tyrosine hydroxylase activity of the striatum was reduced to immeasurably low values, but neither aldehyde dehydrogenase, aldehyde reductase, nor acetylcholine esterase was affected when compared with the striatum from the intact side of the same rat or with those from control rats. These results indicate that in the rat the 3 enzymes are not localized with tyrosine hydroxylase, in the dopaminergic nerve terminals of the striatum. This conclusion is supported by a study of the subcellular localization of aldehyde dehydrogenase in rat brain. This enzyme is distributed between the cytosol and the particulate fraction of brain homogenates separated by centrifugal techniques. with no exceptionally high concentration of the enzyme in the synaptosomal fraction. Because neither of the enzymes of post-deaminative catabolism of dopamine is concentrated in the dopaminergic nerve terminals of the striatum of the rat, it is proposed that in this species the amine is not necessarily taken up by the nerve terminals prior to catabolism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1975.tb07640.x
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  • 3
    Electronic Resource
    Electronic Resource
    Psychopathology and brain dysfunction - C. Shagass, S. Gershon and A. Friedhoff (Eds.): (Raven Press, New York, 1978, 399 pp., 22.50)
    Amsterdam : Elsevier
    Biological Psychology 7 (1978), S. 219-221 
    Details
    ISSN: 0301-0511
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Psychology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0301-0511(78)90017-0
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  • 4
    Electronic Resource
    Electronic Resource
    Experimental approaches to psychopathology - M. KIETZMAN, S. SUTTON and J. ZUBIN (Eds.) (Academic Press, New York, 1975, 19.00)
    Amsterdam : Elsevier
    Biological Psychology 5 (1977), S. 319-320 
    Details
    ISSN: 0301-0511
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Psychology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0301-0511(77)90018-7
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  • 5
    Electronic Resource
    Electronic Resource
    Effects of adrenal steroids and their reduced metabolites on hippocampal long-term potentiation
    Amsterdam : Elsevier
    The @Journal of Steroid Biochemistry and Molecular Biology 40 (1991), S. 87-92 
    Details
    ISSN: 0960-0760
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0960-0760(91)90171-Z
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  • 6
    Electronic Resource
    Electronic Resource
    Modulation by adrenal steroids of limbic function
    Amsterdam : Elsevier
    The @Journal of Steroid Biochemistry and Molecular Biology 39 (1991), S. 245-252 
    Details
    ISSN: 0960-0760
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0960-0760(91)90070-L
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  • 7
    Electronic Resource
    Electronic Resource
    Effects of 18-hydroxydeoxycorticosterone on central nervous system excitability (1986)
    Springer
    Cellular and molecular life sciences 42 (1986), S. 1027-1028 
    Details
    ISSN: 1420-9071
    Keywords: 18-OH-DOC ; brain ; excitability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The effects of 18-hydroxydeoxycorticosterone (18-OH-DOC) on central nervous system excitability were studied in adrenalectomized rats. Sixty-four evoked potentials (EP) recorded from the pontine reticular formation were averaged before and after the injection of vehicle and hormone. 750 μg of 18-OH-DOC dissolved in 0.5 ml of a 4∶1 saline Cremophor-EL solution were injected i.v. A decrease of 55.7±6.1% in the amplitude of the EPs was observed with the hormone 16.3 min±2.7 (SE) after injection. Amplitude values returned to baseline levels 38 min±6.8 (SE) after injection. The secretion of 18-OH-DOC is greatly increased by ACTH and might modulate central nervous system function.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01940717
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  • 8
    Electronic Resource
    Electronic Resource
    Role of Dorsal Columns in sequential motor acts requiring precise forelimb projection (1973)
    Springer
    Experimental brain research 18 (1973), S. 165-177 
    Details
    ISSN: 1432-1106
    Keywords: Dorsal columns ; Accuracy ; Projected movements
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Quantitative evaluation was carried out on the ability of cats to execute a sequential act requiring precise timing for its initiation (jump), accurate projection of the forelimb and appropriate visual tracking during motor performance. Comparison of results before and after section of the Dorsal Columns at the first cervical level revealed obvious postoperative inefficiency in the overall performance of the act. The accuracy of extrapersonally projected movements of the forelimbs (reaching towards a moving target) was seriously affected, as was the capacity to visually track a target in space during the jump. Testing which did not require jumping up towards the target, but merely rearing on the hindlimbs, showed no improvement in the performance of lesioned animals when compared to controls. The deficits mentioned also persisted in animals subjected to preoperative overtraining and prolonged postsurgical testing, a procedure which in certain tasks allows the animal to perform normally after surgery. Physiologically, the Dorsal Columns have been shown to be the exclusive path of fibers from muscle spindles and low threshold joint receptors from the forelimbs. The corresponding fibers from the hindlimbs reach higher centers via different pathways. The loss of this information from forelimbs resulting from high cervical Dorsal Column section may then help to explain the deficits described.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00234721
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  • 9
    Electronic Resource
    Electronic Resource
    Impairments in limb actions after dorsal funiculi section in cats (1979)
    Springer
    Experimental brain research 37 (1979), S. 31-40 
    Details
    ISSN: 1432-1106
    Keywords: Dorsal funiculi ; Force ; Hindlimbs ; Forelimbs
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A study of the forces exerted by cats against the ground when jumping from a platform equipped with force transducers, was carried out. The study, complemented by film analysis of the jump, attempted to disclose some of the mechanisms underlying the decrease in efficiency and accuracy in releasing a moving piece of liver observed after dorsal funiculi section above C1 level. The results showed that after the lesion, peak force and height of jump were significantly reduced. However, angle of take-off, an index of force distribution in the three axes of rectangular coordinates remained unchanged. Intact cats consistently extend their forelimbs in a smooth and progressive way toward the liver in order to release it. The distance between the tips of the forelimbs remained more or less constant during the flight. Postoperatively, instead of the regular pattern described, the extension of the limbs was interrupted by fast marked flexion movements and the distance between their tips increased significantly during the flight. Peak extension of the forelimbs was also decreased after surgery. The results are interpreted in terms of the different disruption of the various components (proprio and exteroceptive) that make up fasciculus gracilis and cuneatus of the dorsal funiculi.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01474251
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  • 10
    Electronic Resource
    Electronic Resource
    Pelvic floor muscles response to graded rectal distension and cutaneous stimulation (1991)
    Springer
    Digestive diseases and sciences 36 (1991), S. 1761-1767 
    Details
    ISSN: 1573-2568
    Keywords: external ani aphincter ; levator ani ; defecation ; electromyographic activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The responses of the external ani sphincter (EAS) and the levator ani (LA) muscles to graded rectal distension and to cutaneous and genital stimulation were examined in 25 cats of either sex. The animals were anesthetized with sodium pentobarbital (30 mg/kg, intraperitoneal) and then tested in two positions: with hindlimbs extended and with hindlimbs flexed simulating the straining position. Graded rectal distension was performed at two speeds: 1 and 10 sec. Basal levels of activity in the EAS were higher in the straining than in the extended position (P〈0.005). The EAS responded to rapid rectal distension with inhibition of its activity. When changed to the straining position significant increases in muscular activity were observed after 35 cc of balloon insufflation (P〈0.005). In the same muscle, slow distension produced an initial decrease in activity followed by significant increases after insufflation of 40 cc in the extended position and of 30 cc in the straining position. Basal activity in the LA was similar in both positions tested. The main effects of rectal distension in this muscle were increases in activity, significant only after high volumes of air inflation in the straining position (P〈0.0001). Cutaneous stimulation disclosed a receptive field that was widespread for the EAS, extending over lumbosacral dermatomes (L3-S2), but greatly restricted for the LA. Responses to vaginal and cervical stimulation were more reliably obtained from the LA (P〈0.001). These differences indicate that the EAS and LA muscles of the cat correspond with distinct, although related neural circuits.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01296622
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