Library

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK; Malden , USA : Blackwell Science Ltd
    Scandinavian journal of immunology 59 (2004), S. 0 
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Soluble forms of selectins may play a regulatory role in inflammatory responses that are key to the pathophysiology of rheumatic diseases such as rheumatoid arthritis (RA) and systemic sclerosis (SSc). The aim of this study was to examine whether the elevated serum-soluble (s) selectin levels are associated with RA or SSc. Serum sE-, sL- and sP-selectin levels were measured by sandwich enzyme-linked immunosorbent assay in 34 RA patients, 30 SSc patients and 16 healthy subjects. The levels of sE-selectin were significantly higher in RA and SSc patients than those in healthy subjects. The sL-selectin level was significantly lower in RA patients compared to healthy subjects. Serum sP-selectin levels were not significantly different among the study groups. The active RA patients had significantly higher serum sE- and sL-selectin levels compared to inactive RA patients. Also, some correlations were observed between the serum selectin levels and measures of disease activity such as erythrocyte sedimentation rate and C-reactive protein in RA patients. The higher levels of sE-selectin were found in SSc patients with pulmonary fibrosis, and there was also a negative correlation between diffusion capacity for carbon monoxide and serum sE-selectin. Serum levels of selectins may provide a useful additional marker for disease activity in RA patients and for disease severity in SSc patients.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    ISSN: 1437-160X
    Keywords: Systemic lupus erythematosus ; IgG deficiency ; Corticotherapy ; Lupus vulgaris
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We present the case of a patient with juvenile onset systemic lupus erythematosus (SLE) who developed a persistent, acquired hypogammaglobulinaemia with IgG deficiency. The hypogammaglobulinaemia was probably a complication of high dose corticosteroid treatment. The serum IgG level remained subnormal despite intravenous immunoglobulin therapy. Lupus vulgaris, which developed on the nasal cartilage in this patient with SLE, is not an expected finding. This patient is probably the first reported case of SLE associated with lupus vulgaris.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Rheumatology international 16 (1996), S. 141-144 
    ISSN: 1437-160X
    Keywords: Rheumatoid arthritis ; Osteoarthritis ; Synovial fluid ; Interleukin-6
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This study evaluated interleukin-6 levels as an activity criterion in rheumatoid arthritis (RA) and compared if with other activity criteria. We evaluated 35 patients with active RA, 31 with inactive RA, and 25 patients with osteoarthritis, in addition to 28 healthy individuals. Serum interleukin-6 levels were higher in active RA patients than in those with inactive RA, or osteoarthritis and healthy individuals (P〈0.001). Serum interleukin-6 levels of patients with active RA were positively correlated with the erythrocyte sedimentation rate, C-reactive protein, andα 2-globulin levels (P〈0.001), but there was a negative correlation with serum albumin levels (P〈0.05). We conclude that interleukin-6 can be responsible for both the most systemic manifestations of RA and for its local manifestations.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Der Radiologe 37 (1997), S. 945-953 
    ISSN: 1432-2102
    Keywords: Key words Computed tomography • Magnetic resonance • Middle ear • Temporal bone ; Schlüsselwörter Mittelohr • Computertomographie • Magnetresonanztomographie • Mittelohr ; Entzündung • Mittelohr ; Mißbildung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Da im Mittelohr in erster Linie knöcherne Strukturen und lufthältige Räume von pathologischen Veränderungen betroffen sind, ist die hochauflösende CT (HRCT) in Dünnschichttechnik in der Auswertung im Knochenfenster, in axialer und koronaler Ebene durchgeführt, die Methode der ersten Wahl. Die HRCT besitzt einen sehr hohen Kontrast zwischen Knochen, Luft und Weichteilgewebe sowie eine hohe Ortsauflösung. Die Indikationen zur HRCT umfassen akute und chronisch entzündliche Prozesse, Cholesteatome oder Tumore, das „operierte Mittelohr“ sowie die Abklärung von Mißbildungen des Mittelohres. Mit der HRCT ist es in den meisten Fällen möglich, zwischen entzündlichen Veränderungen, Cholesteatomen und Tumoren zu unterscheiden. Durch die hervorragende Erfassung selbst kleinster knöcherner Details können Veränderungen wie Arrosionen der Gehörknöchelchen oder der Knochenbälkchen des Mastoids, knöcherne Defekte des Tegmens sowie eine Arrosion des knöchernen Labyrinthes bzw. des Fazialiskanals sehr gut dargestellt werden. In der Abklärung des postoperativen Mittelohres können mit der HRCT Gehörknöchelchenrekonstruktionen oder Prothesen exzellent erfaßt werden. Obwohl die HRCT noch derzeit die Methode der ersten Wahl ist, kann die MRT durch ihren wesentlich höheren Weichteilkontrast, durch die Möglichkeit der Wahl verschiedener Sequenzen und der Kontrastmittelgabe im Falle von Weichteilprozessen wichtige Zusatzinformationen zur HRCT liefern und möglicherweise zur genaueren Diagnosestellung beitragen. Dadurch kann die MRT bei unklaren HRCT-Befunden oft noch genauer zwischen entzündlichen und granulomatösen Veränderungen sowie einem Cholesteatom oder einem Tumor unterscheiden. Durch die MRT gelingt auch die genaue Unterscheidung zwischen einer Meningozele oder Meningoenzephalozele sowie anderen Veränderungen wie einem Rezidivcholesteatom oder Tumor. Auch die genaue Erfassung einer Neuritis des N. facialis oder einer Labyrinthitis sowie die möglicherweise vorhandene Mitbeteiligung intrakranieller oder anderer dem Mittelohr benachbarter Strukturen ist mit der MRT sehr gut möglich. Die MRT ist somit als Zusatzuntersuchung nach der Durchführung einer HRCT, bei welcher unklare Befunde oder Komplikationen wie das Übergreifen von Mittelohrveränderungen in benachbarte Strukturen vorliegen, einzusetzen.
    Notes: Summary High-resolution computed tomography (HRCT) provides excellent contrast between osseous structures, air and soft tissue in conjunction with high spatial resolution. Therefore, thin-section HRCT with bone window setting is the method of choice for the examination of the middle ear structures. The indications are acute and chronic inflammatory changes, cholesteatoma and tumor, the “postoperative middle ear”, and malformations. In most cases, HRCT enables differentiation between inflammatory changes, cholesteatoma, and tumor. The excellent depiction of subtle osseous details enables the identification of erosions of the ossicles or of the bony walls of the mastoid cells, of osseous defects of the tegmen, of the bony labyrinth, and of the tympanic course of the facial canal. In addition, HRCT enables excellent depiction of reconstructions of the ossicles or prosthesis of the ossicles. Although HRCT is the first method of choice, magnetic resonance imaging (MRI) may provide additional information and lead to a more accurate diagnosis in some cases. This is explained by the excellent soft tissue contrast provided by MRI. In addition, MRI offers the possibility of using various pulse sequences and the administration of IV contrast material. Therefore, MRI may allow the differentiation between inflammatory changes, cholesteatoma, and tumor in those cases in which accurate diagnosis cannot be made by HRCT. The differentiation between a meningocele or meningoencephalocele and other entities such as tumors or cholesteatoma can be established by MRI. Furthermore, MRI can accurately depict cases of labyrinthitis or of neuritis of the facial nerve or of intracranial disease caused by middle ear processes, while this is not always possible by HRCT. In summary, HRCT of the middle ear is the method of choice, but MRI may provide supplementary information in those cases in which accurate diagnosis cannot be established by HRCT.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 5
    ISSN: 1434-9949
    Keywords: sICAM-1 ; Systemic Lupus Erythematosus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Circulating sICAM-1 is known to be elevated in various inflammatory disorders. It is further suggested that elevated levels correlate well with disease activity in several autoimmune disorders. The objectives of this study are to determine the serum sICAM-1 levels in patients with systemic lupus erythematosus (SLE) and correlate sICAM-1 levels with clinical and laboratory (ESR, CRP, anti-dsDNA) measures of disease activity. Forty-one patients (34 female, 7 male) all fulfilling 1982 ARA classification criteria for SLE and 16 healthy controls (8 female, 8 male) were included in the study. Disease activity was measured according to SLEDAI. sICAM-1 was determined by ELISA. Mean sICAM-1 in SLE patients (339±161 ng/ml) were significantly higher than in the controls (216±85 ng/ml) (p〈0.005). Although slightly elevated in active patients, there was no statistically significant difference between mean sICAM-1 levels of active and inactive SLE patients (349±183 ng/ml and 316±103 ng/ml respectively) (p〉0.05). We could not find a correlation between sICAM-1 levels and any organ involvements. Similarly, no significant correlation was found between ESR, CRP, anti-ds-DNA and sICAM-1. These results suggest that although higher than normal, sICAM-1 levels in SLE do not provide additional information over conventional activity markers.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...