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  • 1
    Digitale Medien
    Digitale Medien
    A STUDY OF THE INCREASED SERUM LEVEL OF IgG1 IN ‘LETHARGIC’ MICE COMBINED WITH A DEPRESSED THYMUS-DEPENDENT LYMPHOID SYSTEM (1977)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 4 (1977), S. 0 
    Details
    ISSN: 1744-313X
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Biologie , Medizin
    Notizen: In a series of recent studies on ‘lethargic’ mice, a neurological mutation of the mouse, significant abnormalities were discovered in the thymus and its dependent regions in the lymph nodes and spleen. The present study was made as an approach toward finding the possible causes for these abnormalities. Serum IgG1 levels were studied in ‘lethargic’ mutants at the age when severe deficiency of the thymus-dependent lymphoid system is known to occur in the animal. Using the radial immunodiffusion method, it was found that serum IgG1 levels are always significantly higher in ‘lethargic’ mice than in their normal littermates. Possible causes of the higher IgG1 in the serum of ‘lethargic’ mice are discussed. The authors note the similarities of other mouse mutations to that of the ‘lethargic’ mouse and propose the possibility that a common mechanism may account for immunologic deficiencies in several types of mutant mice.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1744-313X.1977.tb00911.x
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  • 2
    Digitale Medien
    Digitale Medien
    Serum proteins of mice with splenomegaly (1979)
    Springer
    Cellular and molecular life sciences 35 (1979), S. 1107-1108 
    Details
    ISSN: 1420-9071
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary Our earlier serum electrophoretic study in ‘lethargic’ mutant mice showed that the quantity of protein in 1 band is inversely related to the size of the spleen. In this study, we demonstrate that this protein band almost entirely disappears in mice with splenomegaly following spontaneous skin infection. The results suggest that this serum protein may play a role in regulating growth of lymphoid tissue.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01949971
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  • 3
    Digitale Medien
    Digitale Medien
    Electron microscopic study of involuting thymus of “lethargic” mutant miceThis study was supported by an Institutional Research grant at The University of Texas Medical School at San Antonio and a research grant from Morrison Trust, San Antonio, Texas. (1973)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 177 (1973), S. 585-601 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: The thymus, which undergoes spontaneous involution three weeks after birth in “lethargic” mutant mice, was studied by electron microscopy. Ultrastructural alterations observed in the involuting thymus of “lethargic” mice resemble those of acute thymic involution induced by the administration of adrenal corticosteroids. The responsive cells in thymic involution of “lethargic” mice were cortical thymocytes, macrophages, and epithelial cells. The first indication of the involution was the appearance of a large number of degenerating thymocytes in the cortex. Pyknotic nuclei of degenerating thymocytes were observed within the macrophages. Macrophages of the involuting thymus were characterized by their content of thymocyte pyknotic nuclei as well as a variety of cytoplasmic inclusions. Cytoplasmic inclusions were also found in the epithelial cells. The inclusions were of two different types: (a) tonofibrils in markedly increased numbers in relation to a non-involuted thymus, and (b) large vacuoles with dense bodies and/or myelin figures, as found in a normal cell, but several times the number one would expect to find. A large number of lipid-laden cells were found in the involuted thymus. This type of cell was not seen in the normal thymus. Numerous Hassall's corpuscles were also found in the involuted thymus of “lethargic” mice.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091770411
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  • 4
    Digitale Medien
    Digitale Medien
    Relationship between the adrenal cortex and thymic involution in “lethargic” mutant mice (1976)
    New York, NY [u.a.] : Wiley-Blackwell
    American Journal of Anatomy 147 (1976), S. 255-263 
    Details
    ISSN: 0002-9106
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: To determine if the adrenal gland plays a role in the thymic involution which occurs spontaneously in “lethargic” mutant mice, three different studies were made. Morphological studies were made first to determine if there was an indication of histological changes in the adrenal glands. Next, serum levels of corticosterone were measured by radioimmunoassay. Finally, mice were unilaterally adrenalectomized to see if such treatment would improve various symptoms of “lethargic” mutants. Results of the studies showed that lipid granules in the cortical cells of “lethargic” mutants were greatly reduced in number during the time of spontaneous thymic involution, and the mutant mice had a significantly higher level of serum corticosterone than the normal controls. Mutant mice unilaterally adrenalectomized at 15 days of age showed a marked improvement in their condition and their mortality rate decreased. It is concluded that spontaneous thymic involution of “lethargic” mutants is probably associated with adrenocortical hypersecretion.
    Zusätzliches Material: 7 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/aja.1001470209
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  • 5
    Digitale Medien
    Digitale Medien
    Change in water proton relaxation time during erythrocyte maturation (1983)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 116 (1983), S. 409-414 
    Details
    ISSN: 0021-9541
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Biologie , Medizin
    Notizen: Erythrocyte populations from newborn and mature mice were characterized according to: size; ultrastructural features; water content; concentration of intraerythrocyte elements including Na, Cl, K, P, S, Mg, and Fe; and the spin-lattice (T1) and spin-spin relaxation times of water protons as measured by nuclear magnetic resonance (NMR) spectroscopy. A significant increase in the T2 time from 142 ± 3 msec to 184 ± 3 msec occurred during erythrocyte maturation. This change in T2 time was correlated with a change from a polyribosome-rich hemoglobin-poor cell type to a polyribosome-absent hemoglobin-rich cell type. The change in T2 time could also be correlated to a significantly higher K and P concentration in the mature erythrocytes. The change in T2 time was not correlated to a change in cellular water content or to the concentration of any of the other elements measured by electron probe X-ray microanalysis. If the NMR relaxation times of water molecules truly reflect their average motional freedom, then the findings suggest that greater water ordering interaction occurs in the ribosome containing immature erythrocyte.
    Zusätzliches Material: 4 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/jcp.1041160320
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