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  • 1
    Electronic Resource
    Electronic Resource
    Determination of metapramine in plasma by gas chromatography with nitrogen-selective and electron-capture detection (1977)
    s.l. : American Chemical Society
    Analytical chemistry 49 (1977), S. 2354-2357 
    Details
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ac50022a056
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Influence of cell immobilization on the production of benzaldehyde and benzyl alcohol by the white-rot fungi Bjerkandera adusta, Ischnoderma benzoinum and Dichomitus squalens (1997)
    Springer
    Applied microbiology and biotechnology 47 (1997), S. 708-714 
    Details
    ISSN: 1432-0614
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract Three white-rot basidiomycetes, Bjerkandera adusta, Ischnoderma benzoinum and Dichomitus squalens, were cultivated on a liquid medium supplemented with l-phenylalanine, a precursor for benzaldehyde (bitter almond aroma) and benzyl alcohol. Remarkable amounts of benzaldehyde (587 mg l−1) were found in cultures of B. adusta. Immobilization of this fungus on polyurethane foam cubes allowed an 8.3-fold increase of the production of benzaldehyde and a 15-fold increase of the productivity as compared with non-immobilized cells. Aryl-alcohol oxidase activity was only detected in B. adusta. This activity was also significantly enhanced in immobilized cells, suggesting that it plays an important role in benzaldehyde biosynthesis. Conversely, consistent amounts of benzyl alcohol (340 mg l−1 for B. adusta and I. benzoinum and 100 mg l−1 for D. squalens) were produced by the three fungi when immobilized. Laccase activity was found only in the strains I. benzoinum and D. squalens. This activity was markedly enhanced in free cells cultures. Immobilization of the fungi did not promote benzyl alcohol production by comparison with free cell cultures (500 mg l−1).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002530050999
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Inhibitory effects of anticancer drugs on dextromethorphan-O-demethylase activity in human liver microsomes (1993)
    Springer
    Cancer chemotherapy and pharmacology 32 (1993), S. 491-495 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The dextromethorphan-O-demethylase activity determined in human liver microsomes was used to screen various anticancer drugs for their ability to inhibit this cytochrome CYP2D6-dependent activity. Competitive inhibition indicates that the drug binds the enzyme and is potentially subjected to a polymorphic metabolism. Among the 13 anticancer drugs tested, 4 compounds caused competitive inhibition of dextromethorphan-O-demethylation: lomustine (Ki=7.7 μM), doxorubicin (Ki=75 μM), vinorelbine (Ki=22 μM), and vinblastine (Ki=42 μM). The results of these studies indicate that the metabolism of the drugs concerned is possibly altered in poor metabolizers of debrisoquine and requires further investigation to study their specific routes of biotransformation. The metabolism of these drugs probably involves various biotransformation pathways, among which the CYP2D6-dependent route would be of minor importance. A second hypothesis is that these drugs could be inhibitors of the isozyme without being a substrate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00685896
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    High-Performance Liquid Chromatography Determination of Acitretin in Plasma and Its Application to a Pharmacokinetic Study in Human Subjects (1992)
    Springer
    Pharmaceutical research 9 (1992), S. 1365-1369 
    Details
    ISSN: 1573-904X
    Keywords: acitretin ; high-performance liquid chromatography ; plasma ; pharmacokinetic
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1015834123735
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Osmotic, biomass, and oxygen effects on the growth rate of Fusarium oxysporum using a dissolved-oxygen-controlled turbidostat (1989)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 33 (1989), S. 699-705 
    Details
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The system described is a modified Hospodka's turbidostat. This device helps to measure the maximum growth rate of fungi in steady-state aerobic conditions with defined and independent concentration of dissolved oxygen, biomass, and substrate even unlimited. The principle consists of a turbidostat controlled by the dissolved oxygen concentration. The inlet medium pump operates when the dissolved oxygen concentration falls below the set point value. This method allows us to study independently effects of different physical and chemical variables on the maximum specific growth rate of microorganisms. A fungus, Fusarium oxysporum 47 isolated from soil, does not show a depressive effect on growth when dissolved oxygen concentration decreases to 5% and osmotic potential to -25 bars. Increasing biomass concentration in the range 0.1-1.0 g/L appears to depress markedly the maximum growth rate.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260330607
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  • 6
    Electronic Resource
    Electronic Resource
    Evaluation of Bayesian estimation in comparison to NONMEM for population pharmacokinetic data analysis: Application to pefloxacin in intensive care unit patients (1992)
    Springer
    Journal of pharmacokinetics and pharmacodynamics 20 (1992), S. 653-669 
    Details
    ISSN: 1573-8744
    Keywords: pefloxacin ; population pharmacokinetics ; intensive care unit ; Bayesian estimation ; NONMEM
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The pharmacokinetics of pefloxacin (PF) were investigated in a population of 74 intensive care unit patients receiving 400 mg bid as 1-hr infusion using (i) Bayesian estimation (BE) of individual patient parameters followed by multiple linear regression (MLR) analysis and (ii) NONMEM analysis. The data consisted of 3 to 9 PF plasma levels per patient measured over 1 to 3 dosage intervals (total 113) according to four different limited (suboptimal) sampling 3-point protocols. Twenty-nine covariates (including 15 comedications) were considered to explain the interpatient variability. Predicted PFCLfor a patient with median covariates values was similar in both BE/ MLR and NONMEM analysis (4.02 and 3.92 L/hr, respectively). Bilirubin level and age were identified as the major determinants of PFCLby both approaches with similar predicted magnitude of effects (about 40 and 30% decrease of median CL,respectively). Confounding effects were observed between creatinine clearance (26% decrease of PF CLin the BE/MLR model), simplified acute physiology score (a global score based on 14 biological and clinical variables) (18% decrease of median CLin the NONMEM model) and age (entered in both models) which were highly correlated in our data base. However, both models predicted similar PF CLfor actual subpopulations by using actual covariate values. Finally, the NONMEM analysis allowed identification of an effect of weight on CL(decrease of CL for weight 〈65 kg) whereas the BE/MLR analysis predicted an increase of CLin patients treated with phenobarbital. In conclusion, both approaches allowed identification of the major risk factors of PF pharmacokinetics in ICU patients. Their potential use at different stages of drug development is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01064424
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  • 7
    Electronic Resource
    Electronic Resource
    Molar mass control of poly(N-isopropylacrylamide) and poly(acrylic acid) in aqueous polymerizations initiated by redox initiators based on persulfates (1998)
    Weinheim : Wiley-Blackwell
    Macromolecular Chemistry and Physics 199 (1998), S. 1387-1392 
    Details
    ISSN: 1022-1352
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Poly(N-isopropylacrylamide) (PNIPAM) and poly(acrylic acid) (PAA) were synthesized by aqueous radical polymerization initiated by the redox couple ammonium persulfate/sodium metabisulfite. PNIPAM was also synthesized by using a similar redox system: ammonium persulfate/2-aminoethanethiol hydrochloride (AET), the reducing agent being in this case a well known chain transfer agent. The final products were characterized by size exclusion chromatography. The influence on the weight-average molar mass (M̄w) of several factors, such as monomer concentration and ionic strength of the reaction solution, were investigated. It was found that the concentration of ammonium persulfate does not practically affect the M̄w of the products for both polymers investigated and independently of the reducing agent used. On the contrary, for constant monomer concentration, M̄w is inversely proportional to the concentration of the reducing agent, either sodium metabisulfite or AET. This behaviour, combined with similar observations concerning the synthesis of polyacrylamide and other redox initiator systems containing metabisulfite as reducing agent, proves the special role of this reducing agent in the aqueous radical polymerizations.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
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