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  • 1
    Electronic Resource
    Electronic Resource
    THE TIME REQUIRED FOR MATERIALS INJECTED INTO THE RETE TESTIS TO REACH POINTS IN THE CAPUT EPIDIDYMIS OF THE RAT AND OBSERVATIONS ON THE ABSORPTION OF CATIONIC FERRITIN (1982)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 383 (1982), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1982.tb23192.x
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  • 2
    Electronic Resource
    Electronic Resource
    CYTOPLASMIC FILAMENTS IN FETAL LEYDIG CELLS (1982)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 383 (1982), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1982.tb23214.x
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  • 3
    Electronic Resource
    Electronic Resource
    Alpha-lactalbumin-like Proteins in the Male Reproductive Tract (1984)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 438 (1984), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1984.tb38271.x
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  • 4
    Electronic Resource
    Electronic Resource
    Effect of Substrate on the Shape of Sertoli Cells in Vitroa (1984)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 438 (1984), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1984.tb38303.x
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  • 5
    Electronic Resource
    Electronic Resource
    Further Observations on the Microfilament Bundles of Sertoli Cell Junctional Complexes (1984)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 438 (1984), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1984.tb38311.x
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  • 6
    Electronic Resource
    Electronic Resource
    Characterization and cellular localization of PSG in rat testis (1997)
    Springer
    Molecular and cellular biochemistry 177 (1997), S. 229-237 
    Details
    ISSN: 1573-4919
    Keywords: pregnancy-specific b1-glycoprotein ; cDNA ; rat ; Sertoli ; Leydig ; myoid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract In order to establish the rat testis as a model system for studying the human pregnancy-specific b1-glycoprotein (PSG), expression and cellular distribution of PSG in rat testis were examined. Three partial PSG cDNAs, namely, rnCGM6, rnGCM7, and rnCGM8 were obtained when rat testis cDNA libraries were screened with a human placental PSG cDNA probe. Unlike the human PSGs, the rat PSGs show less nucleotide and amino acid sequence homology among family members. The rat PSGs also have multiple truncated leader sequences followed by immunoglobulin variable-like N domains while human PSGs have a single N domain. Examination of the testis, intestine, kidney, liver, lung, and muscle of male rats by reverse transcription-polymerase chain reaction (RT-PCR) with nested gene-specific primers showed that rnCGM6 was present only in the testis, while rnCGM8 was present in the testis, intestine and lung. On the other hand rnCMG7 was found in all tissues examined. Furthermore, rnCGM7 transcript was present in all somatic cells examined whereas rnCGM6 was predominantly in myoid cells and rnCMG8 in Leydig cells. These results suggest that there is cell-specificity in the expression of PSGs in the rat testis and that the rat testis is a good model for studying the biological activities of the PSGs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006811305616
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  • 7
    Electronic Resource
    Electronic Resource
    Regulation of c-fos mRNA expression in Sertoli cells by cyclic AMP, calcium, and protein kinase C mediated pathways (1996)
    Springer
    Molecular and cellular biochemistry 156 (1996), S. 43-49 
    Details
    ISSN: 1573-4919
    Keywords: follicle-stimulating hormone ; c-fos ; Sertoli cell ; testis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract The role of second messenger pathways, cyclic AMP, calcium, and protein kinase C (PKC) in the transcriptional regulation of c-fos protooncogene expression in rat Sertoli cells was investigated. c-fos expression was monitored by Northern blot analysis. Although the action of FSH on Sertoli cells is considered to be mediated by CAMP, dibutyryl CAMP (dbcAMP), a potent membrane permeable analog of cAMP, induced much less c-fos mRNA expression than FSH (〈50%) suggesting that additional cAMP-independent mechanisms may mediate the effect of FSH on c-fos. Specific intracellular inhibitors of PKC decreased c-fos induction in response to FSH by more than 50%. lonomycin, which increases intracellular free calcium concentration, induced c-fos expression significantly. These data demonstrate that Sertoli cell c-fos mRNA expression is under multifactorial regulation by CAMP, calcium, and PKC.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00239318
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  • 8
    Electronic Resource
    Electronic Resource
    Dual compartment (bicameral) culture: role of basement membrane in epithelial differentiation (1992)
    Springer
    Cell biology and toxicology 8 (1992), S. 55-59 
    Details
    ISSN: 1573-6822
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: A number of years ago we reported that tight junctions between adjacent Sertoli cells subdivide the seminiferous epithelium into two compartments, basal and adluminal, thus forming the morphological basis of the blood-testis barrier. It is now generally believed that the special milieu created by the Sertoli cells in the adluminal compartment is essential for germ cell differentiation. In order to duplicate the compartmentalization that occurs in vivo, Sertoli cells were cultured in bicameral chambers on Millipore filters impregnated with a reconstituted basement membrane. Confluent monolayers of these cells were tall columnar (40–60 µ in height) and highly polarized. These Sertoli cell monolayers established electrical resistance that peaked when the Sertoli-Sertoli tight junctions developed in culture. In addition, the monolayers formed a permeability barrier to 3H-inulin and lanthanum nitrate. The bicameral chambers were utilized in a number of studies on protein secretion, and it was revealed that numerous proteens are secreted in a polarized manner. In another study, hormone- stimulated aromatase activity was measured in Sertoli cells grown on plastic culture dishes, plastic dishes coated with laminin or Matrigel, and in the bicameral chambers. Cell culture on basement membrane substrate decreased the FSH-dependent estrogen production. No estrogen production was observed when the Sertoli cells were cultured in the bicameral chambers. These results are in accord with the hypothesis that differentiated Sertoli cells lose their ability to metabolize androgen to estrogen in an hormone-dependent manner, whereas undifferentiated cells in culture, or in vivo, have a very active FSH-dependent aromatase activity. This bicameral culture system could serve as an important model system to examine various functions of Sertoli cells including interactions of Sertoli cells with germ, Leydig, and myoid cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00130511
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  • 9
    Electronic Resource
    Electronic Resource
    Spermatogenesis in the vasectomized monkey: Quantitative analysis (1983)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 205 (1983), S. 381-386 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The seminiferous epithelium in mature vasectomized Macaca fascicularis was examined quantitatively to assess spermatogenesis. Monkeys were bilaterally vasectomized and controls were bilaterally sham operated. At postoperative periods of 10 and 18 months, groups of monkeys were castrated and their testes prepared for morphologic analysis. Diameters were measured in 100 cross sections of seminiferous tubules from each animal. Numbers of spermatogonia (Ad and Ap), preleptotene spermatocytes, pachytene spermatocytes, and step 7 spermatids, relative to Sertoli cell nucleoli, were counted in stage VII tubules. Tubule diameter and germ cell numbers per Sertoli cell nucleoli were not altered by vasectomy. Our study demonstrates quantitatively that spermatogenesis in the monkey is not inhibited up to 18 months following vasectomy.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1092050403
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  • 10
    Electronic Resource
    Electronic Resource
    Endocytic activity of Sertoli cells grown in bicameral culture chambers (1987)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 218 (1987), S. 306-312 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Immature rat Sertoli cells were cultured for 7 to 14 days on Millipore filters impregnated with a reconstituted basement membrane extract in dualenvironment (bicameral) culture chambers. Electron microscopy of the cultured cells revealed the presence of rod-shaped mitochondria, Golgi apparatus, rough endoplasmic reticulum, and Sertoli-Sertoli tight junctions, typical of these cells in vivo. The endocytic activity of both the apical and basal surfaces of the Sertoli cells was examined by either adding alpha2-macroglobulin (alpha2-M) conjugated to 20 nm gold particles to the apical chamber or by adding 125I labeled alpha2-M to the basal chamber. During endocytosis from the apical surface of Sertoli cells, the alpha2-M-gold particles were bound initially to coated pits and then internalized into coated vesicles within 5 minutes. After 10 minutes, the alpha2-M-gold was found in multivesicular bodies (MVBs) and by 30 minutes it was present in the lysosomes. The proportion of alpha2-M-gold found within endocytic cell organelles after 1 hour of uptake was used to estimate the approximate time that this ligand spent in each type of organelle. The alpha2-M-gold was present in coated pits, coated vesicles, multivesicular bodies, and lysosomes for approximately 3, 11, 22, and 24 minutes, respectively. This indicates that the initial stages of endocytosis are rapid, whereas MVBs and lysosomes are relatively long-lived. Since alpha2-M-gold was unable to permeate from the basal chamber through the Millipore filter to Sertoli cells, the uptake of alpha2-M from the basal cytoplasm of Sertoli cells was studied using 125I-alpha2-M. After 2 hours incubation, approximately 1.7% of the added 125I-alpha2-M was taken up specifically by the basal cytoplasm of the Sertoli cells. Both alpha2-M-gold and 125I-alpha2-M could be displaced by increasing concentrations of unlabeled alpha2-M. This indicates that alpha2-macroglobulin was internalized by a receptor-mediated endocytic process both from the apical surface and the basal surface of confluent epithelial sheets of Sertoli cells grown in bicameral culture chambers.
    Additional Material: 12 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1092180312
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