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  • 1
    ISSN: 1439-6327
    Keywords: Key words Androgens ; Testosterone ; Human trial
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To determine if known androgenic hormone precursors for testosterone in the androgen pathway would be readily transformed to testosterone, eight male subjects [mean age 23.8 (SEM 3) years, bodymass 83.1 (SEM 8.7) kg, height 175.6 (SEM 8.5) cm] underwent a randomized, double-blind, cross-over, placebo-controlled oral treatment with 200 mg of 4-androstene-3,17-dione (Δ4), 4-androstene-3β,17β-diol (Δ4Diol), and placebo (PL). The periods of study were separated by 7 days of washout. Blood was drawn at baseline and subsequently every 30 min for 90 min after treatment. Analysis revealed mean area-under-the-curve (AUC) serum Δ4 concentrations to be higher during Δ4 treatment [2177 (SEM 100) nmol · l−1] than Δ4Diol [900 (SEM 96) nmol · l−1] or PL [484 (SEM 82) nmol · l−1; P 〈 0.0001]. The Δ4 treatment also revealed a significant effect on total testosterone with a mean AUC [1632.5 (SEM 121) nmol · l−1] that was greater than PL [1418.5 (SEM 131) nmol · l−1; P 〈 0.05] but not significantly different from those observed after Δ4Diol treatment [1602.9 (SEM 119) nmol · l−1; P = 0.77]. Free testosterone concentrations followed a similar pattern where mean AUC for the Δ4 treatment [6114.0 (SEM 600) pmol · l−1] was greater than after PL [4974.6 (SEM 565) pmol · l−1; P 〈 0.06] but not significantly different from those observed after Δ4Diol [5632.0 (SEM 389) pmol · l−1; P = 0.48]. The appearance and apparent conversion to total and free testosterone over 90 min was stronger for the Δ4 treatment (r = 0.91, P 〈 0.045) than for Δ4Diol treatment (r = 0.69, NS) and negatively correlated for PL (r = −0.90, P 〈 0.02). These results would suggest that Δ4, and perhaps Δ4Diol, taken by month are capable of producing in vivo increases in testosterone concentrations in apparently healthy young men as has already been observed in women after treatment with Δ4.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1439-6327
    Keywords: Key words Critical power ; Creatine ; Exercise ; Anaerobic capacity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The relationship between work rate (W˙) and time to exhaustion (t) during intense exercise is commonly described by either a hyperbolic function (NLin), t=W ′/(W˙−W˙ cp), or by its linear equivalent (LinW) W lim =W ′+W˙ cp(t). The parameter W˙〈INF 〈/INF〉cp (critical power) has been described as an inherent characteristic of the aerobic energy system, while W ′ has been shown to be a ralid estimate of anaerobic work capacity. Recent studies have demonstrated that oral supplementation of creatine monohydrate (CrH2O) increases total muscle creatine stores, and have linked these increases to improved performances in intense intermittent exercise. This study was conducted to determine the effect of CrH2O supplementation on estimates of W ′ and W˙〈INF 〈/INF〉cp derived from the NLin and LinW equations, and to determine the effect of CrH2O on t in exhaustive constant power exercise of different intensities. Fifteen active but untrained university students completed three phases of testing on a cycle ergometer: (1) familiarization, three learning trials, (2) baseline determination of W ′ and W˙〈INF 〈/INF〉cp, four bouts performed at a W˙ selected to elicit fatigue in 90–600 s, and (3) experimental determination of W ′ and W˙ cp, four bouts performed at the same W˙ as baseline, but performed after 5 days of ingesting either a placebo (4 × 6 g of glucose/day) or CrH2O (4 × 5 g of CrH2O and 1 g glucose/day). Testing was administered in a double-blind manner. Analyses of covariance revealed a significant effect for CrH2O on both estimates of W ′ (NLin, P=0.04; LinW, P〈0.01), but not on estimates of W˙ cp (NLin, P=0.37; LinW; P=0.30). Within groups, t was significantly different for only CrH2O at the two highest W˙s (P=0.04). It is concluded that oral ingestion of CrH2O increases estimates of W ′ due to an improved t at the shorter, more intense exercise bouts.
    Type of Medium: Electronic Resource
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