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  • 1
    Electronic Resource
    Electronic Resource
    Cholesterol embolic disease presenting as renal failure with acute pancreatitis (1997)
    Springer
    Clinical and experimental nephrology 1 (1997), S. 136-141 
    Details
    ISSN: 1437-7799
    Keywords: cholesterol embolism ; acute renal failure ; acute pancreatitis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Renal failure and acute pancreatitis developed in a 63-year-old man after 2 angiography procedures and iliac artery surgery. The results of the renal biopsy showed no specific abnormalities and the cause of the pancreatitis could not be determined. The patient was treated with hemodialysis and conservative management for pancreatitis, however he died due to sepsis approximately 50 days after diagnosis. The autopsy revealed cholesterol crystals in several organs including the kidneys, pancreas, and spleen. Therefore, systemic cholesterol emboli may have contributed to the development of renal failure and acute pancreatitis in this case. Cholesterol crystals in the pancreas have frequently been observed at autopsy in patients with cholesterol emboli. The clinical development of acute pancreatitis, however, is quite rare in these cases. The present case is reported to increase awareness of the possible clinical presentations of systemic cholesterol embolic disease in an effort to increase the correct diagnosis of this condition.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02479913
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  • 2
    Electronic Resource
    Electronic Resource
    Angiography of experimental autoimmune uveoretinitis with ultrastructural correlation (1998)
    Springer
    Graefe's archive for clinical and experimental ophthalmology 236 (1998), S. 865-872 
    Details
    ISSN: 1435-702X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  · Background: Indocyanine green (ICG) angiography has been used to evaluate posterior uveitis in the clinical setting, despite the shortage of data on possible pathological correlates of observed findings. · Methods: We used both ICG angiography and fluorescein angiography to examine rats that developed a mild form of experimental autoimmune uveoretinitis (EAU) induced by immunization with interphotoreceptor retinoid-binding protein (IRBP). Angiography was performed on days 9, 10, 11 and 23 after IRBP immunization, and freshly enucleated eyes obtained on the same days were examined histopathologically by light microscopy and transmission electron microscopy. · Results: Diffuse dilatation and tortuosity of the retinal vessels was observed by both ICG and fluorescein angiography, with leakage from these vessels in focal areas in the periphery. In addition, deep hyperfluorescent spots in the central posterior pole, not associated with retinal vessels, were observed by ICG angiography only. These corresponded to Dalen-Fuchs-like nodules on funduscopy. On histopathological examination, eyes showed inflammatory cell infiltration around retinal vessels, disorganization of outer retinal layers, focal subretinal accumulations of cells (resembling Dalen-Fuchs nodules), and diffuse inflammatory cell infiltration in the choroid. Ultrastructural examination of a Dalen-Fuchs-like nodule revealed a mound of monocytes, appearing to contain phagosomes of lipofuscin and phospholipids, sandwiched between transformed retinal pigment epithelium (RPE) cells with disrupted apical processes and loss of basal interdigitation. · Conclusion: These results suggest that ICG angiography may be useful in delineating certain abnormalities at the level of the RPE, in association with posterior ocular inflammation, that cannot be observed by fluorescein angiography alone.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004170050172
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Characterization of gene expression in clinical lung cancer materials by two-dimensional polyacrylamide gel electrophoresis (1994)
    Weinheim : Wiley-Blackwell
    Electrophoresis 15 (1994), S. 382-390 
    Details
    ISSN: 0173-0835
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Fourteen human lung tumors of various histopathological types were subjected to two-dimensional gel electrophoresis (2-DE). Samples were prepared for 2-DE using a nonenzymatic sample preparation (NESP) technique recently established in our laboratory. Variations in the expression of some polypeptides were observed between tumors of different histopathological types. To this end, high expression of β-tubulin, heat shock proteins 73 and 90, lamin B, and proliferating cell nuclear antigen (PCNA) were observed in small cell lung carcinomas (SCLC). One polypeptide of unknown identity (35 kDa, pI 5.5) was significantly overexpressed in primary lung adenocarcinomas compared with SCLC, squamous cell lung carcinomas, metastatic lung adenocarcinomas from colon and rectum, and normal tissue. The amino acid composition of this polypeptide is presented. In summary, combining the NESP technique and 2-DE is an effective approach to define tumor-specific markers.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/elps.1150150157
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    Paper (German National Licenses)
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