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  • 1
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Nuclear Physics B (Proceedings Supplements) 29 (1992), S. 204-208 
    ISSN: 0920-5632
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Nuclear Physics, Section B 387 (1992), S. 467-481 
    ISSN: 0550-3213
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Physics Letters B 291 (1992), S. 278-280 
    ISSN: 0370-2693
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 4
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    Wiesbaden : Periodicals Archive Online (PAO)
    Geographische Zeitschrift. 70:1 (1982) 56 
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    European food research and technology 22 (1911), S. 378-381 
    ISSN: 1438-2385
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1438-2199
    Keywords: Amino acids ; HIV-induced cysteine deficiency ; HIV-induced glutathione deficiency ; Cysteine, role in AIDS ; Glutamate, role in cancer and AIDS ; N-Acetyl-cysteine as a treatment of HIV-infection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary T cells have a weak membrane transport actitivity for cystine but strong transport activity for cysteine. Even moderate variations of the cysteine concentration affect T cell functions in spite of the high concentration of cystine in cultures with physiological amino acid concentrations. The IL-2 dependent DNA synthesis and the activation of cytotoxic T cells are positively regulated by cysteine, while the activity of the transcription factor NFkB and the production of IL-2 are stimulated by active oxygen species and inhibited by cysteine or GSH. Macrophages, in contrast to T cells, take up more cystine than they need and release the excess after intracellular reduction as cysteine into the extracellular space. This “cysteine pumping activity” of macrophages raises intracellular GSH levels and DNA synthesis of T cells in the vicinity. The difference between the cystine transport activities of T cells and macrophages, therefore, enables T cells to switch between prooxidant and antioxidant states. The “cysteine pump” favors selectively the antigen-specific T cells that are about to be stimulated by antigen-presenting macrophages. The capacity of macrophages to take up cystine and to release cysteine is inhibited, however, by elevated extracellular glutamate concentrations. Elevated plasma glutamate levels have been found in several pathological conditions including cancer and HIV-infection. In HIV-infected patients, the hyperglutamataemia is aggravated by hypocystinaemia and hypocysteinaemia. Our studies, therefore, suggest that the cysteine supply is impaired in several pathological conditions with immunodeficiencies including AIDS. N-acetyl-cysteine (NAC) is a safe and well established drug that may be considered for the treatment of patients with HIV-infection.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    International journal of legal medicine 29 (1938), S. 513-517 
    ISSN: 1437-1596
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Notes: Zusammenfassung Es wurde ein ganz selten rasch und unter ungewöhnlichen und irreführenden äußeren Umständen zu Tode führender Fall von akuter Nephritis mitgeteilt.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-1440
    Keywords: Cysteine ; T cells ; HIV infection ; Prooxidant and antioxidant states ; T cell activation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The discovery of decreased plasma cysteine and cystine levels and elevated plasma glutamate levels in HIV-infected patients has led to intense investigations into the role of cysteine in T cell-mediated immune responses. A large body of evidence indicates that certain aspects of the T cell response require the action of active oxygen derivatives while other aspects of the response require the action of antioxidants such as cysteine and glutathione (GSH). The prooxidant and antioxidant states may be required sequentially at different times during T cell activation. The extremely weak cystine transport activity of T cells together with oxidizing metabolites from inflammatory microenvironments appear to be important factors that support the prooxidant state. The relatively high cystine transport activity of the antigen-presenting macrophages, in contrast, provides these cells with a “cysteine pumping” function that allows the antigen binding T cells in their vicinity to shift to the antioxidant state. The difference between the membrane transport activities for cysteine of T cells and macrophages thus appears to be the key element of a mechanism that facilitates both, the prooxidant state of T cells and their regulated shift to the antioxidant state. When T cells do not receive sufficient amounts of cysteine, the intracellular GSH levels and rates of DNA synthesis activity decrease, and the cells may suffer from various manifestations of oxidative damage. Taken together, these experimental observations and conclusions suggest that the reactivity of the immune system may be influenced decisively by the operational range that is defined, on the one hand, by the strength of the prooxidant state, and on the other hand, by the capacity of the macrophages to shift the T cells to the antioxidant state. The elevated mean plasma glutamate and decreased mean cystine levels in HIV infected persons compromise this “cysteine pumping” activity and reduces thereby the operational range.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Virchows Archiv 284 (1932), S. 67-83 
    ISSN: 1432-2307
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Virchows Archiv 368 (1975), S. 51-59 
    ISSN: 1432-2307
    Keywords: Vinylchloride-disease ; Toxic tumors ; Haemangiosarcoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wird über einen tödlichen Fall eines Angiosarkom der Leber bei einem 38jährigen Chemielaboranten berichtet, der einer 3 1/2 jährigen Vinylchlorid-Exposition ausgesetzt war. Das Sarkom hatte bereits ausgedehnt metastasiert. Vorliegender Fall ist der 5. innerhalb der Bundesrepublik, von denen 4 tödlich endeten. Messungen der VC-Konzentration am Arbeitsplatz sind nicht durchgeführt worden. Eine Thrombocytopenie, die in 80% der VC-Krankheit intravital auftreten kann, wurde nicht beobachtet. Mit weiteren VC-bedingten Tumoren in größeren Bevölkerungskreisen muß gerechnet werden, wobei die Möglichkeit auch anderer, extrahepatischer, VC-bedingter Tumoren besteht, was aus tierexperimentellen Untersuchungen geschlossen werden kann.
    Notes: Summary A letal case of angiosarcoma of the liver is reported. The 38 years old chemical laboratory assistant was exposed in vinylchloride medium about 3 1/2 years. The sarcoma metastasised into many other organs. This case is the fifth one reported in the German Federal Republic, in four of the cases the patient died. VC concentration at the work place was not measured. Thrombocytopenia observed in about 80% of the VC cases was not seen. There will be possibly observed further VC-caused tumors in the population. Nevertheless there might be other even extrahepatic VC-caused tumors in man, which could be concluded by animal experimental investigations.
    Type of Medium: Electronic Resource
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