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  • 1
    Electronic Resource
    Electronic Resource
    The Protooncogene bcl-2 Inhibits Apoptosis in PC12 Cells (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 60 (1993), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: During development, many neuronal populations undergo a process of normal, programmed cell death, or apoptosis. Trophic factors regulate this process, but the mechanism by which they suppress apoptosis remains unclear. In the immune system, recent studies have implicated the protooncogene bcl-2 in the lymphocyte survival response to growth factors. To determine whether a similar survival pathway exists in a neuroendocrine cell type, we have expressed bcl-2 in the rat pheochromocytoma PC12 cell line and found that it abrogates the requirement for stimulation by growth factors to survive. bcl-2 expression also substantially delays the onset of injury by the calcium ionophore A23187.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1993.tb03275.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Characteristics of isometric and dynamic strength loss following eccentric exercise-induced muscle damage (2001)
    Copenhagen : Munksgaard International Publishers
    Scandinavian journal of medicine & science in sports 11 (2001), S. 0 
    Details
    ISSN: 1600-0838
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Sports Science
    Notes: Angle-specific isometric strength and angular velocity-specific concentric strength of the knee extensors were studied in eight subjects (5 males and 3 females) following a bout of muscular damaging exercise. One hundred maximal voluntary eccentric contractions of the knee extensors were performed in the prone position through a range of motion from 40° to 140° (0°=full extension) at 1.57 rad  ·  s−1. Isometric peak torque was measured whilst seated at 10° and 80° knee flexion, corresponding to short and optimal muscle length, respectively. Isokinetic concentric peak torque was measured at 0.52 and 3.14 rad  ·  s−1. Plasma creatine kinase (CK) activity was also measured from a fingertip blood sample. These measures were taken before, immediately after and on days 1, 2, 4, and 7 following the eccentric exercise. The eccentric exercise protocol resulted in a greater relative loss of strength (P〈0.05) at short muscle length (76.3±2.5% of pre-exercise values) compared to optimal length (82.1±2.7%). There were no differences in the relative strength loss between isometric strength at optimal length and isokinetic concentric strength at 0.52 and 3.14 rad  ·  s−1. CK activity was significantly elevated above baseline at days 4 (P〈0.01) and 7 (P〈0.01). The greater relative strength loss at short muscle length appeared to persist throughout the seven-day testing period and provides indirect evidence of a shift in the angle–torque relationship towards longer muscle lengths. The results lend partial support to the popping sarcomere hypothesis of muscle damage, but could also be explained by an impairment of activation at short muscle lengths.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1524-4725.2001.110302.x
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  • 3
    Electronic Resource
    Electronic Resource
    Plasma membrane and vesicular glutamate transporter mRNAs/proteins in hypothalamic neurons that regulate body weight (2003)
    Oxford, UK : Blackwell Science, Ltd
    European journal of neuroscience 18 (2003), S. 0 
    Details
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1460-9568.2003.t01-1-03010.x
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  • 4
    Electronic Resource
    Electronic Resource
    Reserpine Affects Differentially the Density of the Vesicular Monoamine Transporter and Dihydrotetrabenazine Binding Sites (1996)
    Oxford, UK : Blackwell Publishing Ltd
    European journal of neuroscience 8 (1996), S. 0 
    Details
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We have studied the effect of a single injection of reserpine (5 mg/kg, s.c.) on the synaptic vesicle monoamine transporter (VMAT) density in the rat striatum, using two labelling procedures: radioimmunolabelling with an antibody against VMAT, and binding of the specific ligand [3H]dihydrotetrabenazine ([3H]TBZOH). In the rostral and medial striatum, the distribution of VMAT immunoreactivity displayed the highest density in the lateral subregions. In the caudal part of the striatum, VMAT immunoreactivity showed increasing density from dorsal to ventral subregions. The VMAT immunoreactivity was not altered 2 and 30 days after the reserpine injection, whereas [3H]TBZOH binding site density, measured on adjacent slices, showed a dramatic decrease at day 2 and a moderate recovery at day 30, suggesting that despite a persistent blockade of [3H]TBZOH binding sites, VMAT protein density was unchanged.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1460-9568.1996.tb01271.x
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  • 5
    Electronic Resource
    Electronic Resource
    Indirect Heating of Alfalfa Juice in Steam-Filled Heat Exchangers (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 50 (1985), S. 0 
    Details
    ISSN: 1750-3841
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Alfalfa juice, a highly proteinaceous liquid, was heated in steamfilled shell and tube and rotating coil heat exchangers to effect protein coagulation. The juice could be preheated prior to entering the heat exchanger by use of a recycle system. Lower fouling rates were obtained when the protein was denatured prior to contacting the exchanger surfaces and when the rotating coil exchanger was used. Chemical cleaning treatments could restore the heat transfer coefficient of a fouled exchanger to the original value.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2621.1985.tb13800.x
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  • 6
    Electronic Resource
    Electronic Resource
    Effects of Duchenne muscular dystrophy on muscle protein synthesis (1982)
    [s.l.] : Nature Publishing Group
    Nature 296 (1982), S. 165-167 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] We studied seven normal fed adult men aged 22-65 yr and five boys with Duchenne muscular dystrophy, aged 12-1 Syr. Three of the patients were wheelchair bound and the two youngest were on the verge of becoming so. Investigations of these subjects using radioactive isotopes would not have been ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/296165a0
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  • 7
    Electronic Resource
    Electronic Resource
    PIROT SCALE PREPARATION OF PROTEIN CONCENTRATES FROM WHEAT MILLRUN AND WHEAT SHORTS USING A WET ALKALINE PROCESS (1980)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 45 (1980), S. 0 
    Details
    ISSN: 1750-3841
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A pilot-scale process for preparing high-protein, low fiber (〈l%) products from 150-lb batches of wheat millrun and shorts using a wet alkaline method is described. The protein concentrates contained 60–70% protein when starch was removed prior to protein precipitation and 25–26% protein with the starch present. Yields of the protein concentrates ranged from 4.1 to 33.6% of the raw material starting weight (dry basis), depending on the processing conditions employed. Yield could be increased by re-extracting the pressed residue. Water requirements for extraction were lowered from 750 to 263 lb by extracting the raw material with the deproteinized mother liquor from the previous lot.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2621.1980.tb07466.x
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  • 8
    Electronic Resource
    Electronic Resource
    The pathology of the lower leg muscles in pure forefoot pes cavus (1995)
    Springer
    Acta neuropathologica 89 (1995), S. 552-559 
    Details
    ISSN: 1432-0533
    Keywords: Key words Pes cavus ; Magnetic resonance imaging ; Pathology ; Morphometry ; Peroneus longus hypertrophy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Enlargement of the peroneus longus muscle is a common occurrence in patients with forefoot pes cavus, and may contribute to the cavus deformity. The present study compares the morphology of up to five lower leg muscles from 17 patients with forefoot pes cavus with those of normal muscles. Eight cases had an identifiable neurogenic cause for the cavus. In four cases of hereditary motor-sensory neuropathy, the tibialis anterior showed more severe damage than the peroneus longus. In two cases of cerebral palsy, fibre atrophy and increased oxidative enzyme activity were observed. In nine clinically idiopathic cases, the histological appearances ranged from normal to generalised fibre atrophy or hypertrophy in individual muscles. There was a trend for the mean fibre area to be greater in peroneus longus than in tibialis anterior in six of the idiopathic group of patients. The muscle cross-sectional area on magnetic resonance imaging was correlated closely with the mean fibre area measured on tissue sections. In idiopathic forefoot pes cavus, fibre hypertrophy in peroneus longus (relative to tibialis anterior) may contribute to the cavus deformity. Muscle fibre hyperplasia may contribute to the peroneal muscle enlargement in Friedreich's ataxia. In none of the cases was peroneus longus enlargement due to fat or fibrous tissue replacement.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00571511
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  • 9
    Electronic Resource
    Electronic Resource
    The pathology of the lower leg muscles in pure forefoot pes cavus (1995)
    Springer
    Acta neuropathologica 89 (1995), S. 552-559 
    Details
    ISSN: 1432-0533
    Keywords: Pes cavus ; Magnetic resonance imaging ; Pathology ; Morphometry ; Peroneus longus hypertrophy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Enlargement of the peroneus longus muscle is a common occurrence in patients with forefoot pes cavus, and may contribute to the cavus deformity. The present study compares the morphology of up to five lower leg muscles from 17 patients with forefoot pes cavus with those of normal muscles. Eight cases had an identifiable neurogenic cause for the cavus. In four cases of hereditary motor-sensory neuropathy, the tibialis anterior showed more severe damage than the peroneus longus. In two cases of cerebral palsy, fibre atrophy and increased oxidative enzyme activity were observed. In nine clinically idiopathic cases, the histological appearances ranged from normal to generalised fibre atrophy or hypertrophy in individual muscles. There was a trend for the mean fibre area to be greater in peroneus longus than in tibialis anterior in six of the idiopathic group of patients. The muscle cross-sectional area on magnetic resonance imaging was correlated closely with the mean fibre area measured on tissue sections. In idiopathic forefoot pes cavus, fibre hypertrophy in peroneus longus (relative to tibialis anterior) may contribute to the cavus deformity. Muscle fibre hyperplasia may contribute to the peroneal muscle enlargement in Friedreich's ataxia. In none of the cases was peroneus longus enlargement due to fat or fibrous tissue replacement.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00571511
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    Paper (German National Licenses)
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  • 10
    Electronic Resource
    Electronic Resource
    Muscle damage in mdx mice (1991)
    [s.l.] : Nature Publishing Group
    Nature 350 (1991), S. 664-664 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SIR - Menke and Jockusch reported1 that hypo-osmotic shock exposes a reduced stability of dystrophin-deficient mdx mouse muscle. However, this is not apparent with experimental models of damage to mdx mouse muscle induced by contractile activity2 or as an enhanced damage response in people with ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/350664b0
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    Paper (German National Licenses)
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