ISSN:
0009-2940
Keywords:
Histidine derivatives
;
Zinc complexes
;
Solution equilibria
;
Chemistry
;
Inorganic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Zinc Complexes of Amino Acids and Peptides, 2[1]. - Coordination of Simple Histidine Derivatives to ZincThe bis(L-histidine)ZnCl2 complex 1 is likely to have tetrahedral ZnN2Cl2 coordination. For the compound (L-histidine)-ZnCl2 · HCl (2) a structure determination has revealed a tetrahedral ZnOCl3 coordination. Of the C-protected histidine derivatives His-OMe and His-NH2 and zinc salts of non-coordinating anions the complexes (His-OMe)2ZnX2 (3) and (His-NH2)2Zn(ClO4)2 (4) were obtained. A structure determination of (His-OMe)2Zn(BPh4)2 · H2O has revealed a ZnN4 coordination with chelating histidine units. Of the N-protected histidine derivative Nα-acetylhistidine the complexes (Ac-His)ZnX · H2O (5, X = ClO4, BF4) have been isolated which are coordination polymers in the solid state. From pH-dependent 13C-NMR studies it is concluced that in solution the imidazole N and carboxyl O are coordinated to zinc in (Ac-His)Zn and (Ac-His)2Zn units. The doubly protected histidine derivative Bz-His-OMe acts as a monodentate ligand forming the tetrahedral complexes (Bz-His-OMe)4Zn(ClO4)2 (6) and [(Bz-His-OMe)2Zn(2,9-dimethyl-o-phenanthroline)](ClO4)2 (7).
Additional Material:
4 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/cber.19931261212
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