ISSN:
1432-2307
Keywords:
CD44
;
Leucocyte-endothelial cell adhesion molecule-1
;
B-lymphocytes
;
B-cell neoplasms
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Lymphocytes leave the blood via post-capillary venules by binding initially to their specialized endothelium. CD44 is a 80–90 kDa hyaluronate-binding glycoprotein involved in binding to endothelium of high endothelial venules (HEV). LECAM-1 is a 75–85 kDa glycoprotein with lectin activity interacting with human peripheral lymph node vascular addressin (PNAd) on HEV. This immunohistochemical study shows that CD44 and LECAM-1 are essentially coordinately expressed on B-lymphocytes. The mode and level of CD44/ LECAM-1 expression dissect the peripheral B-cell development into stages that are closely linked to morphologically defined B-cell compartments. Although statistically correlated in B-cell leukaemias (p〈0.0009) and extranodal B-cell lymphomas (p〈0.003), expression of both molecules was less stringently coordinated in 127 B-cell neoplasms examined. B-cell chronic lymphocytic leukaemia, hairy cell leukaemia and mantle zone lymphoma were CD44/LECAM-1 positive, thus corresponding to their reactive counterparts. Correspondingly, follicular centre cell-derived lymphomas were devoid of both markers. Conversely, CD44 and LEC-AM-1 were infrequently detectable in extranodal malignant B-cell neoplasms, irrespective of their maturational state. Presence versus absence of CD44 and LECAM-1, alone or together, determined neither the leukaemic versus aleukaemic state nor the nodal versus extranodal tumour-forming phenotype of a B-cell tumour.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01660977
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