ISSN:
1432-0533
Keywords:
Ubiquitin
;
Neurofilament
;
Diffuse axonal injury
;
Immunohistochemistry
;
Head Trauma
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Ubiquitin is a protein that targets proteins for non-lysosomal degradation. It has been found to be present in a number of inclusions characteristic of neurodegenerative diseases. Using the fluid percussion model of diffuse axonal injury (DAI), we now report that the reactive axonal swellings and the retraction balls produced in this model stain positively with antiubiquitin immunohistochemistry. Furthermore, the affected axons become ubiquitin positive quickly (with-in the first 6 h after injury). Anti-ubiquitin immunohistochemistry compares well with the recently reported ability of antibodies to low molecular weight neurofilament proteins to demonstrate reactive axonal change in DAI, and it could provide additional clues to the pathogenesis of axonal transection.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00230489
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