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  • 1
    Electronic Resource
    Electronic Resource
    Effects of propranolol on ventricular repolarization in man (1990)
    Springer
    European journal of clinical pharmacology 39 (1990), S. 123-125 
    Details
    ISSN: 1432-1041
    Keywords: propranolol ; cardiac action potentials ; restitution curves ; handgrip ; QT interval ; refractory period
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The acute effects on monophasic action potentials (MAP), QT interval, and right ventricle effective refractory period (V-ERP) of propranolol 0.2 mg · kg−1 body weight have been studied in 10 patients with coronary artery disease. The median duration of MAP at 90% repolarization (MAP90) was shortened from 238 to 228 ms at a constant paced heart rate of 100 beats · min−1, while V-ERP remained unchanged. The median ratio V-ERP/MAP90 increased from 1.00 to 1.03. The electrical restitution curves of the duration of premature action potentials, normalized to those paced at constant heart rate, were more horizontal after propranolol. Isometric handgrip shortened MAP90 from 217 to 211 ms and after propranolol similar shortening was found (215 to 209 ms), although both values were slightly lower than before beta-blockade.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00280044
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Effects of disopyramide on repolarisation and intraventricular conduction in man (1988)
    Springer
    European journal of clinical pharmacology 35 (1988), S. 467-474 
    Details
    ISSN: 1432-1041
    Keywords: disopyramide ; monophasic action potentials ; cardiac electrophysiology effects ; restitution curves ; ventricular tachycardia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Right ventricular repolarisation and refractoriness after therapeutic doses of disopyramide have been studied in 10 patients with coronary artery disease by recording monophasic action potentials (MAP) during programmed stimulation. Using 2 catheters, with the tip of one in the apex and the other in the outflow tract of right ventricle, conduction intervals for propagation of stimuli in the ventricle were also measured. Disopyramide increased the duration of MAP signals at 90% repolarisation (MAP90), the QT-interval and the right ventricular effective refractory period (V-ERP). The ratio refractoriness/action potential duration was slightly increased. Early premature action potentials were more markedly prolonged in relation to steady-state action potentials. The differences between the shortest and longest premature action potentials, however, were not changed significantly. The conduction intervals of the normal and premature paced beats were significantly prolonged. The observed effects of disopyramide on conduction and action potential duration may be of major importance for its effect on termination and slowing ventricular tachycardias. Its influence on the duration of premature action potentials in man is consistent with the results of in vitro studies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00558240
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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