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  • 1
    Electronic Resource
    Electronic Resource
    Some pitfalls in antisecretory drug trials (1967)
    Springer
    Digestive diseases and sciences 12 (1967), S. 973-982 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A standard anticholinergic drug was compared to a sustained-release preparation of the same agent. Two 6-hr. doses of glycopyrrolate were equivalent to one dose of a glycopyrrolate Extentab in suppressing basal gastric secretion in subjects with acid-peptic disease. The effect of subject selection on the trial was tested by preselecting patients on the basis of gastric secretory capacity, subsequently measuring basal gastric secretion, and reassessing drug results against basal secretion. The subjects fell into basal hypersecreting and normosecreting groups. In the latter group, basal secretion and drug-inhibited secretion results were close and threatened the validity of the trial. Neither the diagnosis of acid-peptic disease nor the demonstration of increased gastric secretory capacity is sufficient to qualify a subject for an anti-cholinergic drug trial, since his basal secretion may still be low enough to be confused with a satisfactory drug response. Anticholinergic drugs should be tested in subjects with demonstrated basal hypersecretion to avoid this error. Twelve-hour daytime basal gastric secretion data revealed: (1) unreliability of the initial hours; (2) variation from hour to hour; and (3) wide fluctuations over periods of several hours which were unexplained. To avoid errors from these factors, anticholinergic drug trials should be made over prolonged periods and should include identical control periods in a crossover design.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02233255
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Simple fecal tests of absorption (1971)
    Springer
    Digestive diseases and sciences 16 (1971), S. 97-105 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A prospective study in which the value of four stool screening tests of malabsorption was assessed demonstrated that the Sudan stain for fat, with or without heat and acid, microscopic search for meat fibers and radiotriolein excretion, but not the gelatin film tests, was accurate in 69–79% of studies. Accuracy was lowest in mild steatorrhea and because of this, screening tests were least helpful in patients in whom these tests might have realized their greatest potential value for clinical diagnosis. With high meat intake, stool meal fibers proved as good as, or better than, the other methods for testing for nonspecific malabsorption. The gelatin film test, stool meat fibers and the differential results of the Sudan test before and after heat and acid were of no specific value in distinguishing patients with pancreatic insufficiency from those with other causes of malabsorption; their use for this purpose should be abandoned.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02284442
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    A rapid, new and direct method for isolation and measurement of porphyrins in biological samples by high performance liquid chromatography (1979)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 2 (1979), S. 570-574 
    Details
    ISSN: 0935-6304
    Keywords: Liquid chromatography, HPLC ; Porphyrin analyses in biological samples ; High performance liquid chromatography ; Medically important porphyrins directly and rapidly quantitated ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Reversed-phase high performance liquid chromatography on microparticulate columns of octadecylsilane with elution by a gradient of acetonitrile in phosphate buffer, pH 7.5, separated porphyrin free acids directly in urine for the first time. Interfering fluorescence was removed with a precolumn of large particle size at acid pH. Peak area fluorescence by the method of standard addition was related linearly to amount of a porphyrin from 5 to 60 nanograms. The method was reproducible to ± 13%, able to detect 0.3 nanograms of a porphyrin in a 1 ml urine sample in 45 minutes, and capable of detecting the typical clinical patterns of normal and porphyrinuric urines. Modifications make the method applicable to measurements in other biological samples and to research separations. With the added rapidity of analysis, the method could expand porphyrin analysis in routine clinical medicine.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jhrc.1240020906
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    Paper (German National Licenses)
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