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  • 1
    Electronic Resource
    Electronic Resource
    Effects of medroxyprogesterone acetate therapy on advanced or recurrent breast cancer and its influences on blood coagulation and the fibrinolytic system (1995)
    Springer
    Surgery today 25 (1995), S. 701-710 
    Details
    ISSN: 1436-2813
    Keywords: medroxyprogesterone acetate (MPA) ; advanced or recurrent breast cancer ; blood coagulation ; fibrinolytic system
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of medroxyprogesterone acetate (MPA) therapy on advanced or recurrent breast cancer and its influence on blood coagulation and the fibrinolytic system were compared among three different therapy regimens consisting of cyclophosphamide, adriamycin, and 5-fluorouracil (CAF) + MPA and CAF or MPA alone. A clinical response was observed in 42.9% (9/21) of the patients for CAF + MPA, 36.4% (8/22) for CAF and 23.8% (5/21) for MPA alone. No marked thrombosis or its prodromal condition was observed in any group. The effects on the test values for blood coagulation and the fibrinolytic system did not significantly change in the CAF group. However, both AT-III and protein C significantly increased above the normal ranges in the CAF + MPA and MPA groups. Increases in factor X, plasminogen, and α2-plasmin inhibitor/plasmin complex (PIC) and decreases in fibrinogen, tissue plasminogen activator, and D-dimer, were all observed in the MPA and CAF + MPA groups, especially in the MPA group, although these changes remained within the normal ranges. The data indicated that MPA has various influences on blood coagulation and the fibrinolytic system, but these changes did not suggest activation of the blood coagulation system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00311486
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  • 2
    Electronic Resource
    Electronic Resource
    Characteristics of nipple discharge lesions of the breast and contrast mammography (1974)
    Springer
    Surgery today 4 (1974), S. 112-120 
    Details
    ISSN: 1436-2813
    Keywords: bloody nipple discharge ; intraductal papilloma ; mammary carcinoma ; radical mastectomy ; unpalpable breast lesion ; contrast mammography ; microdochectomy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Nipple discharge is frequently an embarassing sympton of breast disease. Twenty eight of 40 intraductal papillomas had bloody discharge (70 per cent). Among 240 carcinomas only 11, or 4.6 per cent had nipple discharge. The palpability of the intraductal papilloma with nipple discharge was 14 out of 37 (37.8 per cent), in contrast to 21 of 22 (95.4 per cent) mammary carcinomas. Diagnostic accuracy of contrast mammography was 91.9 per cent in unpalpable intraductal papilloma cases. Speculative blind mastectomy against nipple discharge lesion with unpalpable breast mass should be avoided.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02469040
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  • 3
    Electronic Resource
    Electronic Resource
    The effects of estrogen on human breast carcinomas serially transplanted into nude mice (1989)
    Springer
    Surgery today 19 (1989), S. 718-725 
    Details
    ISSN: 1436-2813
    Keywords: estrogen ; nude mouse ; hormone dependency ; human breast carcinomas
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effect and mechanisms of 17β-estradiol (E2) on breast cancer cells were studiedin vivo andin vitro, using 5 human breast carcinomas serially transplanted into nude mice. These carcinoma strains consisted of 4 estrogen receptor (ER) positive tumors and 1 ER negative tumor. Mice bearing these tumors were treated with an intramuscular injection of E2 at a dosage of 50 mg/kg and the tumor doubling time (Td) was calculated in days. The tumor growth was significantly stimulated by E2 in 3 out of the 4 ER positive tumors, the Td of the E2 treated groups being 17.6 days for MCF-7 (control: −17.8 days), 12.8 days for R-27 (control: −12.5 days∼14.5 days) and 10.4 days for Br-10 (control: 14.5 days), however, in the T-61 tumor, the growth was inhibited by E2 in a dose dependent manner. In the case of the ER-negative MX-1 tumor, the tumor cell growth was not affected by E2. Discrepancies between the effects of E2 on ER-positive tumors were further analyzed by examining the steroid hormone receptor status and conductingin vitro growth studies.In vitro clonogenic cell assay reproduced the antitumor activity of E2, indicating that E2 directly inhibits part of the cell growth of T-61 tumors. The above results suggest that this experimental system provides a useful tool for analyzing the mechanism of estrogen in breast cancer and that the clonogenic assay using ER positive specimens can help to identify breast cancers sensitive to estrogen therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02471723
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  • 4
    Electronic Resource
    Electronic Resource
    Frozen-section-guided breast-conserving surgery: Implications of diagnosis by frozen section as a guide to determining the extent of resection (1997)
    Springer
    Surgery today 27 (1997), S. 207-212 
    Details
    ISSN: 1436-2813
    Keywords: breast cancer ; breast conserving surgery ; surgical margin ; frozen section ; local recurrence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This study was conducted to analyze retrospectively the results of performing sector resection on 56 breasts in 54 patients with breast cancer. The glands were resected with a 2-cm tumor-free margin on both lateral sides and the distal side, and with more than a 3-cm tumor-free margin on the nipple side. The frequency of positive resection margins for the cancer cells was 7/56 (12.5%) on the nipple side and 12/46 (26.1%) on the lateral sides, with an overall frequency of 15/56 (26.8%). There were positive resected margins for cancer cells on both the nipple and lateral sides in 4/46 patients (9%) Assuming the equivocal margins were positive for cancer cells, an accurate diagnosis by frozen section examination was made in 51 of the 56 operations (91.1%). Additional resection of the margins was performed in all 20 cases of a positive resected margin for cancer cells according to the diagnosis by frozen section. Thereafter, the resected margins became negative in 13 cases (65%), but remained positive in 7 cases (35%). These results show that performing diagnosis by frozen section of the surgical margins is an effective guide to resecting tumors adequately.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00941646
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  • 5
    Electronic Resource
    Electronic Resource
    Effectiveness of an adriamycin immunoconjugate that recognizes the c-erbB-2 product on breast cancer cell lines (1996)
    Springer
    Surgery today 26 (1996), S. 501-507 
    Details
    ISSN: 1436-2813
    Keywords: Adriamycin ; breast cancer ; c-erbB-2 ; immunoconjugate ; targeting therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Adriamycin (ADM) was chemically conjugated to a murine monoclonal antibody, A0011, which recognizes the c-erbB-2 product, via a disulfide bond using N-succinimidyl-3-(2-pyridyldithio) propionate (SPDP) and 2-iminothiolane (2-IT). The molar ratio of ADM to the monoclonal antibody ranged from 15:1 to 25:1 and enzyme-linked immunosorbent assay (ELISA) showed that the binding activity of the conjugate was almost retained. We compared the efficacy of A0011 alone, ADM alone, the A0011-ADM conjugate, and a nonspecific murine IgM-ADM conjugate, against the human breast cancer cell lines SK-BR-3, MDA-MB-361, MCF-7, and BT-20. The A0011-ADM conjugate was observed to be ten times more cytotoxic to the cell lines overexpressing the c-erbB-2 product, namely, SK-BR-3 and MDA-MB-361, than free ADM, but it showed weak cytotoxicity against the cell lines with a low level of c-erbB-2 product expression, namely, MCF-7 and BT-20. However, free A0011 and nonspecific murine IgM-ADM conjugate showed no cytotoxicity toward any of the four cell lines, while the addition of a tenfold molar excess of A0011 inhibited conjugate cytotoxicity. These data suggest that conjugate cytotoxicity is antibody-mediated. Moreover, conjugate cytotoxicity at 10−6M was correlated with antigen volume, and the data were fitted to the regression equation y=−11.63logX+116.38 where the correlation coefficient =0.950. Our results indicate that targeting therapy aiming at the c-erbB-2 product may be useful in the treatment of breast cancers overexpressing the c-erbB-2 product.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00311556
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  • 6
    Electronic Resource
    Electronic Resource
    Influence of estrogen metabolism on proliferation of human breast cancer (1997)
    Springer
    Breast cancer research and treatment 42 (1997), S. 57-64 
    Details
    ISSN: 1573-7217
    Keywords: estrogen metabolism ; breast cancer ; catecholestrogen ; estrone sulfatase ; noncancerous tissue
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In order to investigate the influence of estrogenmetabolism on human breast cancer, estradiol 2- and16α-hydroxylase (2- and 16α-OHase) activities were determined inthe microsomal fractions of cancer tissues by usingreverse phase HPLC. 2-OHase activity was detected inmost cancer tissues and noncancerous tissues, but theactivity was significantly lower in cancer tissues thanin the paired noncancerous tissues (0.01 〈 p〈 0.02). Interestingly the patients without lymph nodemetastasis had significantly higher 2-OHase activity in cancertissues than those with lymph node metastasis (0.02〈 p 〈 0.05). No correlation was observedbetween ER status and 2-OHase activity in cancertissues. On the other hand, 16α-OHase activity wasdetected only in one third of the breastcancer tissues examined. The activity was not significantlydifferent from that in noncancerous tissues, although itwas relatively higher in ER-positive cancer tissues whencompared with that in ER-negative ones (0.05 〈p 〈 0.1). Estrone sulfatase activity measured simultaneouslyin the cytosol fractions of some specimens wasmuch higher in cancer tissues than in noncanceroustissues (0.02 〈 p 〈 0.05). We found,however, no correlation between estrone sulfatase activity andestradiol hydroxylase activity. Taken together, our results suggestthat the increase in 2-OHase activity prevents theproliferation of breast cancer and that estradiol metabolismis regulated independently of the local biosynthesis ofestrogen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/B:BREA.0000010495.08233.09
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