ISSN:
1432-0584
Keywords:
Hairy Cell Leukemia
;
NK activity
;
Single cell cytotoxicity assay
;
Membrane phenotype
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Peripheral blood lymphocytes (PBL) of eleven patients with Hairy Cell Leukemia were studied for surface phenotype and for NK activity against the K 562 cell line (using both the standard 51Cr Release Assay and the Single Cell Cytotoxicity Assay on poly-L-lysine coated coverslips). A significant reduction in NK activity, target binding cells (TBC) and NK active cells (NKa) was detected. In some cases however, despite a very low percentage of NKa, residual NK activity was observed, suggesting an efficient recycling capacity.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00321093
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