ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The synthesis of [Sar1, Val5, (4′-azido-3′,5′-ditritio)Phe8] angiotensin II from a iodinated precursor peptide is described. The principal problems of this synthesis and their resolution are discussed: (i) The β-induced autophotolysis of the highly tritiated (73 Ci/mmol) and photosensitive label, and (ii) the absorption problems encountered during the purification of microgramm quantities. Such photoaffinity labels are being used for specific labeling and isolation of peptide hormone receptors.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19800630523
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