Electronic Resource
Oxford, UK
:
Blackwell Publishing Ltd
Journal of cardiovascular electrophysiology
5 (1994), S. 0
ISSN:
1540-8167
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
Flecainide. Flecainide is a Class IC antiarrhythmic agent whose primary electrophysiologic effect is a slowing of conduction in a wide range of cardiac tissues. It is well absorbed and effective in suppressing isolated premature ventricular contractions (PVCs) or nonsustained ventricular arrhythmia but has only a modest efficacy when electrophysiologic testing is used as an endpoint. Us adverse effect on mortality in the CAST trial suggested a propensity to proarrhythmia-a phenomenon to which the Class IC agents appear particularly prone. Despite the applicability of the CAST study only to patients with a prior myocardial infarction, there has been a shift away from flecainide in ventricular arrhythmia, but the low noncardiac side effect profile of the agent allows for its continued use in a wide variety of supraventricular arrhythmias. (J Cardiovasc Electrophysiol, Vol. 5, pp. 964–981. November 1994)
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1540-8167.1994.tb01136.x
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