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  • 1
    Electronic Resource
    Electronic Resource
    The Adenosine Triphospate (ATP) Test for Evaluation of Syncope of Unknown Origin (2005)
    350 Main Street , Malden , MA 02148-5018 , USA , and 9600 Garsington Road , Oxford OX4 2DQ , UK . : Blackwell Science Inc
    Journal of cardiovascular electrophysiology 16 (2005), S. 0 
    Details
    ISSN: 1540-8167
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1540-8167.2005.00171.x
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  • 2
    Electronic Resource
    Electronic Resource
    Reproducibility of the Adenosine-5′-Triphosphate Test in Vasovagal Syndrome (1998)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cardiovascular electrophysiology 9 (1998), S. 0 
    Details
    ISSN: 1540-8167
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Vasovagal Syndrome: ATP Test Reproducibility. Introduction: Adenosine-5′-triphosphate (ATP) provokes negative chronotropic and dromotropic vagal effects. In vasovagal syndrome, ATP test (20-mg IV bolus infusion) represents a promising technique for identifying patients at risk of severe cardioinhibitory response of vagal origin. The electrocardiographic and related symptom reproducibility of this descriptive test must be assessed. Methods and Results: In order to achieve this objective, ATP tests were performed twice in 80 patients (44 men, 36 women; mean age 72.3 ± 12.2 years) by using the recently published test procedure and criteria of positivity. The second test was repeated shortly after the initial test (mean: 7 days) in 43 patients and long-term (mean: 3.7 years) in 37 patients. The initial ATP test provoked a cardiac pause 〉 10 seconds in 31 patients (39%) and a short cardiac pause (〈 10 sec) or n pause in 49 patients (61%). The electrocardiographic outcome was reproduced during the second ATP test in 36 patients (84%) of the short-term group and in 29 patients (78%) of the long-term group. Similarly, symptoms were reproduced in 38 patients (88%) of the short-term group and 29 patients (78%) of the long-term group, reflecting the severity of the electrocardiographic outcome. Conclusion: The negative chronotropic and dromotropic vagal effect of ATP can he reproduced short term and long term in 84% and 78% of patients, respectively. Associated symptoms were related to the severity of the electrocardiographic outcome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1540-8167.1998.tb00087.x
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  • 3
    Electronic Resource
    Electronic Resource
    Myocardial infarction: Is bepridil, a new calcium antagonist, able to improve the course of the acute phase? (1989)
    Springer
    Cardiovascular drugs and therapy 2 (1989), S. 771-781 
    Details
    ISSN: 1573-7241
    Keywords: myocardial infarction ; calcium antagonists ; bepridil
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Several calcium antagonists are useful in the treatment of ischemic heart disease. This open randomized study was designed to determine the effects of bepridil, a new long-acting calcium antagonist with antiarrhythmic properties, on the course of acute myocardial infarction (AMI). Two hundred patients with AMI of less than 48 hours duration (average 10.9 hours) were randomly assigned to two treatment groups: The first one was treated with bepridil (BEP, n=100), and the second one was considered as a control group, using isosorbide dinitrate at a low dosage (ISDN, n=100). BEP was administered intravenously for 48 hours at a dosage of 4 mg/kg/day; at the same time, an oral dose of 200 mg t.i.d. was started and continued for 21 days. In the control group, ISDN was given orally at the low dosage of 5 mg every 4 hours for 21 days. An uneventful course was seen in 28 BEP patients versus 15 in the control group (p〈0.05). Mortality and recurrence of angina were lower in the BEP group than in the control group, but the difference is not significant. On the other hand, moderate and severe hemodynamic complications did not occur in 80 BEP patients versus 65 in the control group (p〈0.05). Ventricular arrhythmias occurred in 36 BEP patients versus 50 in the control group (p〈0.05). Antiarrhythmic therapy was required in 14 BEP patients versus 61 in the control group (p〈0.001). These results show that bepridil seems capable of improving the hemodynamics and arrhythmologic course of AMI.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00133207
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    Paper (German National Licenses)
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