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  • 1
    Electronic Resource
    Electronic Resource
    Ultraviolet light induction of peripheral granulocytosis with splenomegaly: protection of mice with topical p-aminobenzoic acid (PABA) (1991)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 125 (1991), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary Hairless mice were exposed to UVB irradiation from a Philips T1 12 light source. Mice that were exposed to UV-light and not protected with 5%p-aminobenzoic acid (PABA) showed a significantly higher number of peripheral blood granulocytes (P〈0·001) and a significantly higher mean weight of both the spleen and the liver (P〈0·001) than the non-irradiated controls. light microscopy of the histology of the enlarged liver and spleen showed a proliferation of granulocytes and the reticuloendothelial cells. Treatment with topical PABA during the whole period of UV-exposure prevented the peripheral blood granulocytosis. These protected mice also had a significantly (P 〈0·001) lower mean weight for the liver and spleen than UV-exposed and non-protected mice.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1991.tb14744.x
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  • 2
    Electronic Resource
    Electronic Resource
    The inhibiting effect of PABA on photocarcinogenesis (1990)
    Springer
    Archives of dermatological research 282 (1990), S. 38-41 
    Details
    ISSN: 1432-069X
    Keywords: PABA ; Sunscreening agent ; Ultraviolet carcinogenesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The efficacy of a 5% solution of para-aminobenzoic acid (PABA) to protect against photocarcinogenesis was tested in 6 groups, each of which contained 30 light pigmented hairless mice. The light source was a Phillips TL 40 W/12, which mainly emits UVB. PABA significantly retarded the tumor induction time (p〈0.05) and reduced both tumor yield and carcinoma yield (p〈0.05). The dorsal skin of the mice was removed and weighed. The mean weight of UVR-exposed mice skin protected with PABA did not differ from that of the controls, but in the non-protected UVR-exposed mice the skin samples were significantly heavier (p〈0.05).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00505643
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    Paper (German National Licenses)
    Fulltext
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