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  • 1
    Electronic Resource
    Electronic Resource
    Influence of maternal infections with viral agents or Toxoplasma gondii during pregnancy on fetal IgE production (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Allergy 52 (1997), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The importance of maternal infections with Toxoplasma gondii, cytomegalovirus (CMV), Parvovirus B19, respiratory syncytial virus (RSV), and influenza A and B on fetal IgE synthesis was studied in 153 pregnant women. No case of specific IgM activity or viral DNA in cord blood, indicating a congenital infection, was found. From gestational week 15 to delivery, maternal IgG-Ab seroconversion to Parvovirus B19, RSV, influenza A, or influenza B occurred in 47 women. At delivery, serologic signs of past infection with T. gondii were observed in 29 (19%) women, and the corresponding figure for CMV was 117 (77%). The number of women with positive IgG seroconversion during pregnancy or positive IgG-Ab activity toward the studied infectious agents at delivery did not differ significantly among infants with an increased (≥1.3 kU/1; n=51) or with an undetectable (〈0.1 kU/l; n=102) cord-blood IgE level. These results show that genetic and other environmental factors probably have a greater influence on fetal IgE synthesis than do maternal infections during pregnancy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.1997.tb02417.x
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  • 2
    Electronic Resource
    Electronic Resource
    Syntheses of the p-trifluoroacetamidophenyl glycosides of 2-acetamido-2-deoxy-4-O-α-d-glucopyranosyl-β-d-glucopyranose and 2-acetamido-2-deoxy-6-O-α-d-glucopyranosyl-β-d-glucopyranose
    Amsterdam : Elsevier
    Carbohydrate Research 116 (1983), S. 39-47 
    Details
    ISSN: 0008-6215
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0008-6215(00)90951-0
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  • 3
    Electronic Resource
    Electronic Resource
    Molecular cloning and characterization of a full-length cDNA clone for human plasminogen
    Amsterdam : Elsevier
    FEBS Letters 213 (1987), S. 254-260 
    Details
    ISSN: 0014-5793
    Keywords: (Human) ; Plasma protein ; Plasminogen ; cDNA
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0014-5793(87)81501-6
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  • 4
    Electronic Resource
    Electronic Resource
    Strong Donor Mononuclear Cell Reactivity for Herpes Simplex Virus (HSV) Antigen in HSV Immune Donors Combined with Recipient Seropositivity for HSV is Associated with Acute Graft-versus-Host Disease (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 34 (1991), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Prior to bone marrow transplantation (BMT) titres of IgG antibodies for cytomegalovirus (CMV), herpes simplex virus (HSV) and varicella zoster virus (VZV) were analysed in 51 donors and recipients of allogeneic bone marrow. Donor mononuclear cells from peripheral blood and bone marrow cells were stimulated with antigen prepared from CMV, HSV and VZV. High IgG titres for HSV in the recipient were associated with grade II–III acute graft-versus-host disease (GVHD) (P= 0.05). Furthermore, the combination of positive IgG titre for HSV antibodies in the recipient, and strong donor blood mononuclear cell reactivity to HSV antigen in HSV immune donors, significantly increased the incidence of grade II–III acute GVHD (P= 0.04). The data suggest that HSV immune donor mononuclear cells may initiate a GVH reaction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1991.tb01519.x
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  • 5
    Electronic Resource
    Electronic Resource
    Radiographic patterns and viral studies in childhood pneumonia at various ages (1995)
    Springer
    Pediatric radiology 25 (1995), S. 627-630 
    Details
    ISSN: 1432-1998
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We aimed at evaluating the relationship between microbial, etiology and chest radiograph appearance in various types of pneumonia. In a prospective study, the radiographic findings in 479 cases of acute pneumonia in children were compared with viral etiology and growth of potential bacterial pathogens in nasopharyngeal secretion. As the basis for viral etiology was most conclusive, the material was here classified according to the viral findings. The patients were divided into three age groups: 0–2, 3–5 and 6–15 years. The chest radiograms were analyzed blindly for the presence of hyperinflation and interstitial, alveolar and mixed interstitial-alveolar infiltrates. There was a statistically significant relationship between low age and occurrence of hyperinflation and interstitial infiltrates, and between high age and alveolar infiltrates. No unequivocal relationship was found between type of infiltrates or presence of atelectasis and proven viral etiology. We conclude that chest radiographs are not a useful indicator of microbial etiology in childhood pneumonia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02011833
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  • 6
    Electronic Resource
    Electronic Resource
    Indications that maternal coxsackie B virus infection during pregnancy is a risk factor for childhood-onset IDDM (1995)
    Springer
    Diabetologia 38 (1995), S. 1371-1373 
    Details
    ISSN: 1432-0428
    Keywords: Key words Pregnancy; Coxsackie B virus viral infections; Childhood IDDM.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In a population-based setting, we traced serum samples collected at time of birth from 55 mothers whose children later developed insulin-dependent diabetes (IDDM) and matched them pairwise to control subjects who gave birth at the same hospital during the same month. The sera were analysed for IgM antibodies to coxsackie B virus serotypes 2, 3 and 4 (CBV-2, 3 and 4) using a type-specific μ-antibody-capture radioimmunoassay. Despite a decreased power due to the close matching by time of birth we found a significantly higher frequency of CBV-3 IgM at delivery in mothers whose children later became diabetic compared to their matched control subjects. When using the presence of CBV-3 IgM as a risk factor the Mantel-Haenszel odds ratio estimate (95 % confidence limits) was 2.57 (1.02; 7.31), p = 0.043. For CBV-2 and CBV-4, respectively no significant difference was found between mothers of patients and control subjects. According to the odds ratio estimate for CBV-3 and the proportion of exposed mothers among patients estimated in this study the aetiological fraction for this risk determinant would be 27 %. In conclusion, this study indicates that children of mothers who expressed CBV IgM at delivery are at increased risk for developing childhood onset IDDM. A fetal infection with CBV similar to rubella virus may initiate autoimmunity or cause persistent infection that may lead to progressive beta-cell destruction. [Diabetologia (1995) 38: 1371–1373]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250050437
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  • 7
    Electronic Resource
    Electronic Resource
    Indications that maternal coxsackie B virus infection during pregnancy is a risk factor for childhood-onset IDDM (1995)
    Springer
    Diabetologia 38 (1995), S. 1371-1373 
    Details
    ISSN: 1432-0428
    Keywords: Pregnancy ; Coxsackie B virus viral infections ; Childhood IDDM
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In a population-based setting, we traced serum samples collected at time of birth from 55 mothers whose children later developed insulin-dependent diabetes (IDDM) and matched them pairwise to control subjects who gave birth at the same hospital during the same month. The sera were analysed for IgM antibodies to coxsackie B virus serotypes 2, 3 and 4 (CBV-2, 3 and 4) using a type-specific Μ-antibody-capture radioimmunoassay. Despite a decreased power due to the close matching by time of birth we found a significantly higher frequency of CBV-3 IgM at delivery in mothers whose children later became diabetic compared to their matched control subjects. When using the presence of CBV-3 IgM as a risk factor the Mantel-Haenszel odds ratio estimate (95% confidence limits) was 2.57 (1.02; 7.31), p=0.043. For CBV-2 and CBV-4, respectively no significant difference was found between mothers of patients and control subjects. According to the odds ratio estimate for CBV-3 and the proportion of exposed mothers among patients estimated in this study the aetiological fraction for this risk determinant would be 27%. In conclusion, this study indicates that children of mothers who expressed CBV IgM at delivery are at increased risk for developing childhood onset IDDM. A fetal infection with CBV similar to rubella virus may initiate autoimmunity or cause persistent infection that may lead to progressive beta-cell destruction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00401772
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  • 8
    Electronic Resource
    Electronic Resource
    Long-term persistence of intrathecal virus-specific antibody responses after herpes simplex virus encephalitis (1985)
    Springer
    Journal of neurology 231 (1985), S. 307-312 
    Details
    ISSN: 1432-1459
    Keywords: Herpes encephalitis ; Cerebrospinal fluid ; Virus antibodies ; Immunoglobulins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Paired sera and cerebrospinal fluids (CSF) from nine surviving patients were collected 4.5 to 8 years after acute herpes simplex (HS) virus encephalitis. Oligoclonal bands of IgG were detected in the CSF of all, and seven patients had an elevated CSF IgG index. Antibodies to HS, varicella-zoster (VZ), measles, and cytomegalo viruses were analysed by enzyme-linked immunosorbent assay (ELISA) and by imprint immunofixation (IIF) of specimens separated by electrophoresis and by thin-layer electrofocusing. Intrathecal synthesis of HS and VZ IgG antibodies was demonstrated in all and of measles IgG antibodies in one patient by both methods. Intrathecal synthesis of HS IgA antibodies was demonstrated by ELISA in three and by IIF in seven patients; the latter method also disclosed intrathecal synthesis of VZ IgA antibodies in two. No patient had intrathecal synthesis of viral IgM antibodies. The intrathecally synthesized antibodies demonstrated by IIF displayed oligoclonal characteristics. The IIF analyses as well as virus absorption tests indicated that the intrathecally synthesized VZ IgG and IgA antibodies could be explained as HS antibodies cross-reacting with VZV. The results indicate that a long-term persistence of intrathecal antibody reesponses to HS virus is a common feature after acute HS encephalitis. The intrathecal production of measles IgG antibodies in one case may reflect a similar persistence of non-specific immune responses induced during the acute infection.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00313707
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  • 9
    Electronic Resource
    Electronic Resource
    Sequence analysis of echoviruses in a major antigenic region eliciting enteroviral cross-reactive antibodies (1995)
    Springer
    Archives of virology 140 (1995), S. 2085-2091 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The amino acid sequence of an antigenic region known to elicit cross-reactive enteroviral IgG antibodies in VP1 is known for poliovirus and coxsackievirus A and B. However, no corresponding data has been available for prevalent echovirus serotypes with great clinical impact. Such information was obtained by amplification of this region of the echovirus genome by PCR using biotinylated primers. The amplicon was subjected to solid phase sequencing using the dideoxy chain-termination method. Translated amino acid sequences for residues 26–55 of VP1 of the echoviruses revealed that the known crossreactive region is highly conserved also in the echovirus serotypes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01322695
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  • 10
    Electronic Resource
    Electronic Resource
    Two-year survey of the incidence of lyme borreliosis and tick-borne encephalitis in a high-risk population in Sweden (1992)
    Springer
    European journal of clinical microbiology & infectious diseases 11 (1992), S. 894-900 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A survey was made over a two-year period (September 1987 to August 1989) of a population living in an area endemic for Lyme borreliosis and tick-borne encephalitis in Sweden. For each patient a blood sample was collected and a questionnaire completed annually. All sera were tested for an antibody response toBorrelia burgdorferi in an EIA using sonicated antigen and for an antibody response to the tick-borne encephalitis virus using an EIA and a haemagglutination inhibition test. Antibodies toBorrelia burgdorferi and tick-borne encephalitis virus were detected in 89 (25.7 %) and 40 (11.6 %) respectively of 346 samples collected in August 1987. In the first year of the study 14 of 303 subjects (4.6 %) developed Lyme borreliosis and in the second year 9 of 277 subjects (3.2 %). A significant increase in the antibody titre forBorrelia burgdorferi was seen in 14 of 303 (4.6 %) subjects in the first year and 8 of 277 (2.9 %) subjects in the second year. An earlier episode of Lyme borreliosis or an elevated antibody titre did not seem to protect against reinfection. One case of tick-borne encephalitis was seen each year. Seroconversion for tick-borne encephalitis virus was found in 3 of 258 (1.2 %) subjects in the first year and 5 of 211 (2.4 %) in the second year, excluding subjects who had undergone successful immunisation or had earlier been hospitalised for tick-borne encephalitis. The study thus demonstrated a high yearly incidence of tick-borne infections in a population at risk.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01962369
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