ISSN:
1432-1440
Keywords:
Digitoxin poisoning
;
Immunoassay
;
Digitalis antibody Fab-fragment therapy
;
Serum
;
Urine
;
Dialysis
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary A 36 year old male was admitted to the intensive care unit with acute digitalis intoxication after ingestion of 350 digitoxin tablets (=35 mg digitoxin). He was treated with Fab fragments of a digitalis antiserum raised in sheep, the concentrations of digitoxin in serum, urine and dialysates being measured with two automated digitoxin immunoassays based on fluorescence labelling techniques. Whereas one assay reflected the total digitoxin concentrations, including that bound to the antidote, the other measured only the bioactive “free” form of the drug. This article examines the use and limitations of both assay systems in assessing and monitoring cases of digitalis poisoning.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01649024
Permalink