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  • 1
    Electronic Resource
    Electronic Resource
    Compare of Electrospinning PLA and PLA/β-TCP Scaffold in Vitro (2005)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 475-479 (Jan. 2005), p. 2379-2382 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: In recent years, electrospinning process is gradually applied in producingtissue-engineering scaffold. In this study, we chose polylacticacid(PLA) and β-tertiary calcium phosphate(β-TCP) as raw materials to fabricate PLA/β-TCP biodegradable composite scaffold by electrospinning process. The characteristics of the scaffold and effect of the scaffolds to cell proliferation and cell adhesion was studied. Compare with pure PLA scaffold, blendingβ-TCP in the spinning process of the scaffold could improve the properties of the scaffold, especially the hydrophilicity and the proliferation and adhesion of cells, this means that the material is more potential to be used as tissue engineering scaffolds
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/09/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.475-479.2379.pdf
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  • 2
    Electronic Resource
    Electronic Resource
    Comparative Investigation of Coprecipitation and In-Situ Synthesis of Nanohydroxyapatite/Collagen Composite (2005)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 284-286 (Apr. 2005), p. 839-842 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Hydroxyapatite/collagen (HA/COL) composites were prepared using coprecipitation and in-situ synthesis methods. All these processes yielded nanosize poorly crystallized hydroxyapatite/collagen composites. The low temperature in situ formed composites showed some features of natural bone in phase composition, crystal size and crystallinity. Compare with the composite prepared by coprecipitation synthesis, the composite resulted from a low temperature insitu synthesis method showed better homogeneity and mechanical properties. It is confirmed that the low temperature in situ synthesis method was an effective way to obtain biomimetic nanoHA/COL composites with good homogeneity and mechanical properties
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/49/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.284-286.839.pdf
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  • 3
    Electronic Resource
    Electronic Resource
    Gene Expression of C2C12 Cells on Calcium Phosphate Ceramic In Vitro (2005)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 288-289 (June 2005), p. 265-268 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: The osteoinduction of Calcium Phosphate (CaP) had been proved and generally been investigated by in vivo implantation. However, the mechanism of the osteoinductivity was not clear and it was difficult to judge the osteoinductivity in vitro. In this study, Mouse C2C12 cell line, a kind of myoblast precursor cell, was employed to co-culture with CaP. The induction of cell differentiation by materials was tested by MTT method, fluorescence observation, especially the mRNA expression of Osteocalcin, Type I collagen and Fibronectin by RT-PCR. It was founded that C2C12 cells could be induced to expression osteocalcin when growth on the surface of the HA/TCP ceramics. At the same time, the ceramics with different composition and sintering temperature seemed to induce difference expression level of the related genes. The results proved that phase composition was one of the most important factors in the regulation of bone-related genes. This study provided a potential model to evaluate the osteoinductivity of CaP ceramics in vitro
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/49/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.288-289.265.pdf
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  • 4
    Electronic Resource
    Electronic Resource
    Experimental Study on the Osteoinduction of Calcium Phosphate Biomaterials In Vivo and the Capability of Supporting Osteoblast Proliferation In Vitro (2005)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 284-286 (Apr. 2005), p. 293-296 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: The purpose of this study was to evaluate the response of osteoblasts to the calcium phosphate with different surface modification, and to evaluate the osteoinductive capabilities of these biomaterials. 60HA/40α-TCP ceramics sintered at 1250oC was applied in this study. The ceramic cylinder with F5mm×8mm and slice with F10mm×1mm were prepared respectively. One thirds of the ceramics were formed bone-like apatite (BLA), and the surface of another one thirds was modified with collagen. Osteoblasts (1×106/ml) were co-cultured with the three kinds of thin slices for 12h, 24h and 48h. SEM observation was applied to evaluate if the surface modification and BLA formation could affect the attachment and proliferation of osteoblast in vitro. The three kinds of cylinder samples were implanted in dog muscle to evaluate their differences in osteoinduction. Cells grew inmulti-layers and well attached to the surface and proliferated well in the group of collagen and HA/TCP. In untreated and BLA precipitated group, cells did not attach to the surface well. Osteoinduction was good in BLA precipitated group and the amount of bone formed was higher; in untreated group and collagen-treated group, no bone formation was observed in the tested period. This result indicated that the scaffold used in cell-materials composites in vitro and that in osteoinductive material based tissue engineering in vivo was not same
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/49/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.284-286.293.pdf
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  • 5
    Electronic Resource
    Electronic Resource
    Evaluation of Bioactivity and Cytocompatibility of Nano-Hydroxyapatite/Collagen Composite In Vitro (2005)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 284-286 (Apr. 2005), p. 553-556 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/49/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.284-286.553.pdf
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  • 6
    Electronic Resource
    Electronic Resource
    Rat Bone Marrow Cell Responses on the Surface of Hydroxyapatite with Different Topography (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 361-363 (Nov. 2007), p. 1107-1110 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: It is well known that the cellular responses are related with both physical and chemicalcharacteristics of substrate, including surface topography. In the present study，the effect of surfacetopography of hydroxyapatite (HA) on rat bone marrow cell (rBMCs) response was investigated. HAdisc-shaped pellets with various topography were manufactured by single-axis pressing methods. TherBMCs responses on materials including cell morphology and proliferation were evaluated by SEMand MTT methods respectively, and the differentiation potential was assessed by total protein contentand alkaline phosphatase (ALP) activity testing. The results showed that the cell porliferation washigher on HA surfaces with macropore structure, while ALP activity was lower. No significantdifference in the cellular responses on the pore distribution and orietation was observed. However, thepore structure had a potential to guide cell orientation by gathering the cells inside the pores ratherthan on the ridges. Since ALP served as an indicator of early osteoblast differentiation, in this study itshigher expression on HA surface with micropores suggested that surface microtopograhy exhibited animportant effect on early osteoblast differentiation process
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/56/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.361-363.1107.pdf
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  • 7
    Electronic Resource
    Electronic Resource
    Effect of Phase Components on Apatite Formation on the Surface of Ca-P Bioceramics (2005)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 284-286 (Apr. 2005), p. 477-480 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Dense hydroxyapatite (HA) and hydroxyapatite/tricalcium (HA/TCP) were immersed in Fast calcified solution (FCS) at 37℃ in constant temperature culture box for 7 days. It was observed that the phase components of dense ceramics affected the composition, crystallinity and phase components of formed apatites on the surface of ceramics. It is a mixture of hydroxyapatite with a strong preferential crystallographic direction of 002 and octacalcium phosphate (OCP) on the surface of HA/TCP ceramics, whereas only an HA phase was detected on the surface of HA ceramics
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/49/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.284-286.477.pdf
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  • 8
    Electronic Resource
    Electronic Resource
    In Vitro and In Vivo Biocompatibility of Nano-Hydroxyapatite/Collagen Composites (2005)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 288-289 (June 2005), p. 195-198 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: A nano-grade hydroxyapatite/collagen composite was prepared by an in situ synthesis technique from calcium nitrate, diammoniun hydrogen phosphate, and a cowhide collagen sol at low temperature. XRD and TEM analyses of the composite indicated that crystals formed in the collagen fibril matrix were nanohydroxyapatite with low crystallinity. Biocompatibility of the composite was evaluated by in vitro cytotoxicity test and in vivo genotoxicity and sensitization test. No mutagenicactivity of the composite was observed in mouse micronucleus tests. No evidence of dermal sensitization of the composite was found in guinea pig maximization tests. The results from a filter diffusion test indicated that the composite did not induce a cytotoxic behavior. All these results suggest that the composite has excellent biocompatibility
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/49/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.288-289.195.pdf
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  • 9
    Electronic Resource
    Electronic Resource
    Preparation of Nano-Hydroxyapatite/Poly(D,L-Lactide) Composite and Its Degradation in Femora of Rabbits (2005)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 288-289 (June 2005), p. 203-206 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: With the outstanding biocompatibility of hydroxyapatite (HA) and biodegradation ofpoly(D,L)lactide(PDLLA), and the expected good bio-mechanical compatibility, nano-HA / PDLLA (n-HA/PDLLA)composite has been paid great interests in hard tissue repair. One of the key factors affecting the potential of the composite is the degradation of the composite. That is what the mechanism of degradation in the composite is and if the degradation of the materials would induce the crack of the composite or a porous structure facile for tissue ingrowth would be formed. In this study, an n-HA/ PDLLA composite containing about 40% n-HA (wt%) was prepared and the degradation of the composite in bony tissue of rabbits and tissue response were studied by implanting composite rods and control HA rods into the femora of 16 New Zealand rabbits. After definite intervals, the histological analysis was completed by light microscopy and the degradation behavior was observed by scanning electron microscopy. The results suggested that a nano-HA/PDLLA composite was obtained and the materials showed good biocompatibility andosteoconductivity. The substantial degradation of the composite occurred at 8 weeks in vivo. After a longer period of implantation, the further degradation of the composite led to the formation of interconnected microporous and macroporous structure in the materials that might facilitate the tissue ingrowth in the composite
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/49/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.288-289.203.pdf
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  • 10
    Electronic Resource
    Electronic Resource
    In Vivo Evaluation of Nano-HA/PDLLA Composite (2005)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 284-286 (Apr. 2005), p. 881-884 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: The purpose of this study was to evaluate the behavior of nano-hydroxyapatite/poly(D,L)lactide (n-HA/PDLLA) composite in vivo. The composite rods containing about 40wt% n-HA and control HA rods with a diameter of 2mm and a length of 6mm were implanted into the femora of 16 New Zealand rabbits. Composite wafers with a diameter of 5mm and a thickness of 1mm were implanted into the dorsal subcutis of 18 Wistar Albino rats. After definite intervals, the histological analysis was completed by light microscopy and the degradation behavior was observed by scanning electron microscopy. The histological analysis showed no obvious difference between n-HA /PDLLA composite and pure HA that had good biocompatibility and osteoconductivity. SEM analysis of the surface and cross section of the samples showed that the degradation of the composite started from surface, then into the inner gradually and formed multiple pores at surface.The pore size and porosity gradually increased along with time and a porous network may be formed
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/49/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.284-286.881.pdf
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