ISSN:
1573-8221
Keywords:
uterus
;
steroid—receptor interaction
;
specificity
;
estrogens
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract The physicochemical parameters of estradiol—receptor (E2−R) interaction in the cytosol of guinea pig uterus (the velocity constants of association and dissocation, the half-life of the E2−R complex, the change in free binding energy) were studied and the content of receptors in the cell calculated. With different degrees of approximation to a state of equilibrium, for most steroids the percentage of affinity for the test system remained unchanged, indicating that equilibrium had been reached in these cases. The affinity of the steroids for the R system analyzed was determined by integrity of the 3- and 17 β-hydroxyl groups and by the somewhat greater importance of the third phenolic hydroxyl group of the steroid molecule.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00801998
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