ISSN:
1572-8838
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Electrical Engineering, Measurement and Control Technology
Notes:
Abstract Aryl-2 propionic acids such as fenoprofen and ibuprofen, which are anti-inflammatory agents, are synthesized by electrolysing a solution of ArCH(CH3)Cl in the presence of carbon dioxide and a nickel catalyst. The electrolyses are carried out galvanostatically in an undivided cell at a large scale of 50 mmol in 100 ml of solvent (e.g. tetramethylurea). Conversion rates close to 80% and chemical yields up to 85% are achieved. Electrolyses can be performed without catalyst.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01016213
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