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  • 1
    Electronic Resource
    Electronic Resource
    The effects of a kinin antagonist on changes in lung function and plasma extravasation into the airways following challenge of sensitized guinea-pigs (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 26 (1996), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background It has been suggested that kinins may play a role in allergic pathophysiology of the airways, contributing to bronchoeonstrietion and oedema formation. Raised levels of kinin generating enzymes and kinins are found in the airways during allergic responses.Objective Using an in vivo animal model of allergen induced increase in airways resistance we investigated the effects of the brady kinin antagonist Hoe 140, in order to assess the possible contribution of kinins to this response.Methods Guinea-pigs were sensitized and challenged with ovalbumin (OA) or saline via the endotracheal route and the resulting increase in airways resistance was measured by whole body plethysmography. At 240min after challenge, bronchoalveolar lavage fluid (BALF) was taken and albumin content and kallikrein-like activity defennined by rocket immunoelectrophoresis and use of artificial substrates respec tively. Pretreatment of animals with the bradykinin antagonist Hoe 140 at 6.7, 20 or 66.7nmol/kg or aprotinin (46 000 kallikrein inhibitor units/kg) was by i.p. injection 10 min before challenge.Results Pre-treatment with Hoe 140 dose dependently attenuated the increase in airways resistance following allergen challenge. Kallikrein-like activity and albumin in BALF were unaltered. Aprotinin reduced the kallikrein-like activity in BALE but did not alter airways resistance.Conclusion Kinins may contribute to a significant part of allergen-induced airways resistance increase in this model but not via an effect on plasma extravasation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1996.tb00085.x
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  • 2
    Electronic Resource
    Electronic Resource
    Mechanism of irritant-induced cough: Studies with a kinin antagonist and a kallikrein inhibitor (1996)
    Springer
    Lung 174 (1996), S. 269-275 
    Details
    ISSN: 1432-1750
    Keywords: Cough ; Bradykinin ; Kallikrein
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract It has been suggested that bradykinin may play a role in stimulating cough in at least one pathological condition in humans. We have employed an animal model to investigate the possible role of this peptide in irritant-induced cough. The kinin antagonist Hoe 140 and codeine both produced dose-related inhibition of cough responses to inhalation of citric acid or bradykinin aerosols by conscious guinea pigs. The selective tissue kallikrein inhibitor CH694 inhibited cough caused by citric acid but not by bradykinin. Indomethacin pretreatment attenuated the responses to both stimuli as did phosphoramidon. It is concluded that cough produced by citric acid inhalation may be mediated, at least in part, by generation of kinins; secondary to this, a release of prostanoids also appears to participate in the response.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00173141
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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