Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    024
Effects of an Electrical Stimulation Bandage on Wound Healing (2004)
    Oxford, UK; Malden, USA : Blackwell Science Ltd/Inc.
    Wound repair and regeneration 12 (2004), S. 0 
    Details
    ISSN: 1524-475X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Although electrical stimulation (ES) has been successful in the treatment of various types of wounds, the popularity of the treatment has waned due to a lack of optimal methods of administration. The goal of this study has been to develop and evaluate a method of delivering ES that is easy to use and suitable for delivery in a home-health environment.[0] Specifically, a novel bandage system developed to provide an electric field in a manner resembling the natural wound current was tested in vivo. In this study, a full-thickness wound model in New Zealand white rabbits was used to measure the effects of such a bandage system on healing of [0]skin defects. Different levels of current were evaluated initially, with 50 and 20 μA selected for the focus of this study, along with a non-stimulated control. Using histomorphometry healing rates, cellularity, and blood vessels were quantified at one and two week time points.The study showed the ability of this ES bandage to speed the healing process. An increase in overall healing rate over non-stimulated wounds of 45%(p = 0.04) was observed in wounds stimulated with 50 μA of current for 1 week. In wounds treated for 2 weeks, contraction rate decreased as well as the ratio of contraction rate to epithelialization rate. The stimulated wounds also showed an increase in the amount of macrophages, with a 79% increase in number of macrophages in wounds stimulated with 20 μA for 2 weeks and a 198% increase in macrophages in those stimulated with 50 μA compared to non-stimulated wounds. The performance of the bandage in the animal model has led to a limited clinical study on pressure ulcer patients using the 50 μA system. Acknowledgements: This project was funded through Biofisica and the CDC through NCIPC.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1067-1927.2004.0abstracty.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    174
Systemic Vs. Topical Transplantation of Endothelial Progenitor Cells for Wound Healing (2005)
    Oxford, UK; Malden, USA : Blackwell Publishing Ltd/Inc.
    Wound repair and regeneration 13 (2005), S. 0 
    Details
    ISSN: 1524-475X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Previous wound healing studies have attempted to improve angiogenesis (new blood vessel ingrowth). Recent studies suggest, however, that revascularization of wounds may also be accomplished by vasculogenesis: endothelial progenitor cells (EPCs) from the bone marrow and blood that home to sites of tissue damage and form new blood vessels. The goal of this study was to evaluate the use of systemic and topical transplantation of EPCs for wound healing in an in vivo rabbit model. It was hypothesized that applying cells topically through an EPC-seeded albumin scaffold may promote revascularization from inside the wound versus only from the periphery. Further, it was hypothesized that combining topical and systemic transplantation of EPCs may increase vessel formation from both directions. Full thickness wounds were created on the dorsum of New Zealand White rabbits. Wounds were treated with either an EPC-seeded scaffold, nonseeded scaffold, or no treatment (control). Additionally, half of the animals were given systemic injections of EPCs. Digital pictures were taken weekly until sacrifice to determine healing rates. Laser Doppler Perfusion Imaging scans were used to measure changes in blood perfusion during healing. Animals were sacrificed at 2 or 4 weeks; wounds were excised and prepared for histological examination. Histomorphometry was used to calculate epithelialization and contraction rates, as well as the volume fraction of cell nuclei and blood vessels. Preliminary results suggest that animals that received systemic transplantations of EPCs had higher overall healing rates than those with no injection. Systemic transplantation alone improved healing over the control by the end of 2 weeks. When combined with a topical scaffold (both EPC-seeded and nonseeded), systemically injected cells showed improved healing by the end of the first week.Acknowledgments:  This project was supported by CDC through NCIPC and an NSF Graduate Research Fellowship.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1067-1927.2005.130216bz.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    037
Clinical Evaluation of an Electrical Stimulation Bandage (Posifect Dressing) (2005)
    Oxford, UK; Malden, USA : Blackwell Publishing Ltd/Inc.
    Wound repair and regeneration 13 (2005), S. 0 
    Details
    ISSN: 1524-475X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Introduction:  Based on the results of a study showing increased healing rates in a rabbit wound healing model, a clinical study was initiated to assess the safety and efficacy of a new electric stimulation bandage (POSiFECT dressing). Four patients have completed the study for the first-generation system and two are currently enrolled in the evaluation of the second-generation system.Materials and Methods:  Spinal cord-injured pressure ulcer patients were treated with the POSiFECT dressing in a randomized double-blind crossover study. During the first 8 weeks, subjects received a dressing supplying 50 μA of current or one with an unconnected battery. During the treatment, bandages were changed every other day and wounds were assessed weekly to determine size, depth, and condition. At the end of 8 weeks the patients were unblinded and the control group was treated with working bandages for 8 weeks. After cessation of treatment, assessments continued each month for 2 months.Results:  The treatment led to statistically significant increases in healing rates during the first week (0.19 ± 0.11 cm/wk) and the first 2 weeks (0.10 ± 0.07 cm/wk) compared to both the control group (−0.03 ± 0.0 cm/wk) and the follow-up period (−0.02 ± 0.08 cm/wk). For each patient, however, there was a time frame during the 3rd to 5th week of treatment in which significant decreases in healing rate occurred (−0.31 to −0.096).Conclusions:  The POSiFECT dressing appears to increase healing during the first few weeks after application. A modified clinical study is under way with a new dressing design as well as a treatment protocol providing 3 weeks of stimulation followed by 2 weeks without stimulation and then 3 more weeks of stimulation.Acknowledgments:  This project was funded by Biofisica and the CDC through NCIPC.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1067-1927.2005.130215ak.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...