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  • 1
    Electronic Resource
    Electronic Resource
    Gene-culture coevolution between cattle milk protein genes and human lactase genes (2003)
    [s.l.] : Nature Publishing Group
    Nature genetics 35 (2003), S. 311-313 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Milk from domestic cows has been a valuable food source for over 8,000 years, especially in lactose-tolerant human societies that exploit dairy breeds. We studied geographic patterns of variation in genes encoding the six most important milk proteins in 70 native European cattle breeds. We found ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/ng1263
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  • 2
    Electronic Resource
    Electronic Resource
    Cytonuclear disequilibria in wild populations of rabbit (Oryctolagus cuniculus L.) suggest unequal allele turnover rates at the b locus (IGKC1) (1999)
    Springer
    Immunogenetics 49 (1999), S. 629-643 
    Details
    ISSN: 1432-1211
    Keywords: Key words Cytonuclear disequilibria ; Diversity enhancement selection ; Molecular clock ; Histocompatibility antigens ; Immunoglobulin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract  DNA sequence comparisons suggest that evolutionary rates at the rabbit IGKC1 locus can differ among allelic lineages. Here we address the question of whether population turnover rates can vary among IGKC1 alleles. We studied the distribution of sixteen IGKC1 (or b-locus) allotypes in areas comprising the aboriginal species range (Iberian peninsula). Rabbits in this area belong to one of two distantly related mitochondrial lineages (mtDNA types) A and B. In the more recent distribution area of the species, all rabbits belong to the mtDNA type B lineage, and IGKC1 alleles b4 and b5 comprise over 90% of the gene pool. These two alleles are also predominant in areas of mtDNA type B prevalence within the Iberian range. However, in areas of mtDNA type A prevalence, the b4 and b5 allotypes are rare or absent; they apparently have been replaced by serologically related, but distinct, 'endemic' variants. The cytonuclear disequilibria were highly significant, also within the subsample consisting of populations from Spain. These observations suggest that allelic persistence times for the predominant IGKC1 lineages could be shorter than the divergence time of the major mtDNA lineages A and B. In contrast, the relative gene frequencies of the IGKC1 allele b9 were similar among the type A and type B rabbits; it was present in most populations at low frequency. In consequence, persistence times of the b9 allele appear to be longer than the divergence time of lineages A and B. The data reported here are in agreement with the DNA sequence data, providing further proof that the molecular clock can run at different rates among allelic lineages at the rabbit IGKC1 locus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002510050659
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  • 3
    Electronic Resource
    Electronic Resource
    Biochemical and genetic studies on rabbit hemoglobin. I. Electrophoretic polymorphism of theβ chain (1989)
    Springer
    Biochemical genetics 27 (1989), S. 673-678 
    Details
    ISSN: 1573-4927
    Keywords: rabbit ; hemoglobin β chain ; electrophoretic polymorphism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract A genetic polymorphism of β-chain rabbit (Oryctolagus cuniculus) hemoglobin is demonstrated by means of acid starch gel electrophoresis. The biochemical evidence presented suggests that a previously reported substitution of a neutral amino acid for a histidine is responsible for the detected genetic variation. Segregation analysis was performed in a sample of 15 matings with 49 offspring and confirmed the genetic hypothesis: two common alleles at an autosomal locus. The calculated gene frequencies in a random sample of 125 individuals areHBB*1=0.48 andHBB*2=0.52.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00553988
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  • 4
    Electronic Resource
    Electronic Resource
    Genetic Variation in Some Populations of the Golden-Striped Salamander, Chioglossa lusitanica (Amphibia: Urodela), in Portugal (1997)
    Springer
    Biochemical genetics 35 (1997), S. 371-381 
    Details
    ISSN: 1573-4927
    Keywords: Amphibia ; polymorphism ; golden-striped salamander ; Chioglossa lusitanica ; Urodela ; starch gel electrophoresis ; isoelectric focusing
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Genetic variation in the golden-striped salamander (Chioglossa lusitanica) was assessed in 231 individuals from four Portuguese populations by means of horizontal starch gel electrophoresis and isoelectric focusing. Three of 19 enzyme systems, representing 21 presumptive loci, were found to be polymorphic: phosphoglucomutase 1 (PGM1), peptidase B (PEPB), and peptidase D (PEPD). The observed average heterozygosity in Chioglossa lusitanica (0.027) is significantly lower than that observed for other amphibians, either urodeles or salamandrids. Differences in allele frequencies and the presence of private alleles are indicative of a high degree of population differentiation. PEPD, in particular, seems to be a diagnostic locus separating the southernmost population studied from the others.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1022281616801
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  • 5
    Electronic Resource
    Electronic Resource
    Biochemical and genetic studies on rabbit hemoglobin. II. Electrophoretic polymorphism of theα-chain (1990)
    Springer
    Biochemical genetics 28 (1990), S. 117-122 
    Details
    ISSN: 1573-4927
    Keywords: rabbit ; hemoglobin ; α-chain, electrophoretic polymorphism ; neutral amino acids
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract A genetic polymorphism of rabbit (Oryctolagus cuniculus) hemoglobin α chain is demonstrated by means of acid starch gel electrophoresis. The polymorphism is not detected by isoelectric focusing and may be based upon neutral for neutral amino acid substitutions in accordance with previous findings by means of amino acid sequencing. Segregation analysis was performed on 15 matings with 49 offspring and confirmed the initial genetic hypothesis of three common codominant alleles at an autosomal locus. The calculated gene frequencies in a random sample of 86 unrelated individuals areHBA*1=0.73,HBA*2=0.22, andHBA*3=0.05.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00561331
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  • 6
    Electronic Resource
    Electronic Resource
    Biochemical and genetic studies on rabbit hemoglobin. I. Electrophoretic polymorphism of theβ chain (1989)
    Springer
    Biochemical genetics 27 (1989), S. 673-678 
    Details
    ISSN: 1573-4927
    Keywords: rabbit ; hemoglobin β chain ; electrophoretic polymorphism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract A genetic polymorphism of β-chain rabbit (Oryctolagus cuniculus) hemoglobin is demonstrated by means of acid starch gel electrophoresis. The biochemical evidence presented suggests that a previously reported substitution of a neutral amino acid for a histidine is responsible for the detected genetic variation. Segregation analysis was performed in a sample of 15 matings with 49 offspring and confirmed the genetic hypothesis: two common alleles at an autosomal locus. The calculated gene frequencies in a random sample of 125 individuals areHBB*1=0.48 andHBB*2=0.52.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02396059
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  • 7
    Electronic Resource
    Electronic Resource
    New Genetic Variation in European Hares, Lepus granatensis and L. europaeus (2000)
    Springer
    Biochemical genetics 38 (2000), S. 87-96 
    Details
    ISSN: 1573-4927
    Keywords: iberian hare ; brown hare ; genetic polymorphism ; peptidases ; hemoglobin ; α chain ; plasma proteins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Six genetic polymorphisms for the Iberian hare (Lepus granatensis) and four for the brown hare (L. europaeus) are newly described. The genetic variation of peptidases B (PEPB) and C (PEPC), hemoglobin CHKαCHK chain (HBA), hemopexin (HPX), vitamin D binding protein (GC), and properdin factor B (BF) was assessed by conventional electrophoresis and isoelectric focusing in carrier ampholytes and hybrid pH gradients. Six alleles were detected in PEPB, three in PEPC, four in HBA, six in GC, five in HPX, and six in BF. At least one allele was shared between species at all loci except HBA. The allelic overlap between the two species was medium to high in PEPB, GC, and HPX and small in PEPC and BF.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1002715913943
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  • 8
    Electronic Resource
    Electronic Resource
    Separation of human alloalbumain variants by isoelectric focusing (1991)
    Weinheim : Wiley-Blackwell
    Electrophoresis 12 (1991), S. 313-314 
    Details
    ISSN: 0173-0835
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: A technique for the separation of human alloalbumin variants by means of isoelectric focusing in the presence of 8M urea and 60 mM L-serine is described. The potential usefulness of this technique in the detection and classification of genetic heterogeneity at the albumin locus is demonstrated by the differentiation of three human alloalbumin variants of European origin.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/elps.1150120415
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