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  • 1
    Electronic Resource
    Electronic Resource
    Longitudinal red streaks on the big toenails in a patient with pseudobulbar syndrome (2001)
    Oxford, UK : Blackwell Science Ltd
    Journal of the European Academy of Dermatology and Venereology 15 (2001), S. 0 
    Details
    ISSN: 1468-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1468-3083.2001.00180-8.x
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  • 2
    Electronic Resource
    Electronic Resource
    Nail pathology in patients with hemiplegia (2001)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 144 (2001), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background  It is well known that nails can be involved in some diseases of the central nervous system; however, no systematic study has been carried out in order to evaluate the incidence and the possible mechanisms of these nail changes in hemiplegia. Objectives  To study the presence of nail pathology specifically associated with hemiplegia and to evaluate its incidence and its temporal relationship with the onset of the neurological deficit. Methods  In an open study, fingernails and toenails were examined by a dermatologist; 108 were patients with hemiplegia due to a stroke, consecutively admitted to our Department of Neurology between 1995 and 1998, and 121 were normal controls. Results  Onychodystrophy of fingernails and onychomycosis of toenails were found in both patients with hemiplegia and normal controls. However, three conditions (longitudinal reddish striation, neapolitan nails and unilateral clubbing) were only observed in some patients, always affecting fingernails of the limb affected by hemiplegia. Neapolitan nails were present in three (3%) patients with hemiplegia which had its onset 3–14 months earlier. Hemiplegia had occurred approximately 40 months earlier, on average, in six patients (6%) with longitudinal reddish striation, and 60–120 months prior to unilateral clubbing in another two patients (2%). Conclusions  In this study we were able to assess the presence of three different fingernail conditions that were characteristically associated with hemiplegia (longitudinal reddish striation, neapolitan nails and unilateral clubbing), to evaluate their incidence and to study the delay with which these changes occur after a stroke.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.2001.04083.x
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  • 3
    Electronic Resource
    Electronic Resource
    Sleep patterns of Down's syndrome children: Effects of butoctamide hydrogen succinate (BAHS) administration (1986)
    Springer
    Psychopharmacology 90 (1986), S. 119-122 
    Details
    ISSN: 1432-2072
    Keywords: Down's syndrome ; REM sleep ; BAHS
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Several investigators have described the altered sleep patterns in Down's syndrome subjects. The most relevant findings have been a reduction in percentage of REM sleep, a prolonged latency to the first REM episode, an increase in undifferentiated sleep, and a reduced ratio of the oculomotor frequencies. Because it is of interest to identify new drugs able to increase the percentage of REM sleep in mentally retarded subjects, we studied the effects of butoctamide hydrogen succinate (BAHS) on nocturnal sleep in eight young institutionalized Down's syndrome subjects. BAHS produced a significant increase in the percentage of REM sleep as well as a decrease in undifferentiated sleep and latency to the first REM.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00172882
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  • 4
    Electronic Resource
    Electronic Resource
    The specificity of the characteristic sleep EEG pattern in the fragile-X syndrome (1990)
    Springer
    Journal of neurology 237 (1990), S. 65-66 
    Details
    ISSN: 1432-1459
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00319675
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  • 5
    Electronic Resource
    Electronic Resource
    Alterations of nasal mucociliary transport in patients with hypertrophy of the inferior turbinates, deviations of the nasal septum and chronic sinusitis (1999)
    Springer
    European archives of oto-rhino-laryngology and head & neck 256 (1999), S. 335-337 
    Details
    ISSN: 1434-4726
    Keywords: Key words Nasal mucociliary transport ; Sinusitis ; Turbinate hypertrophy ; Septal deviation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Mucociliary transport (MCT) represents the first barrier of the nasal fossae and paranasal sinuses against various biological and physical insults. We studied the nasal MCT time using a mixture of vegetable charcoal powder and 3% saccharin in three groups of patients suffering from hypertrophy of the inferior turbinates, deviations of the nasal septum or chronic sinusitis. The mean values of the nasal MCT in the first two groups were practically identical to the normal ones. In contrast, significantly delayed times were found in patients with chronic sinusitis (P 〈 0.01). Findings indicate that this delay is determined by an increase in viscoelasticity of the mucus following the acute release of mediators of inflammation, together with a reduction in the periciliary stratum, which slows down the metachronous wave of the MCT.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004050050158
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  • 6
    Electronic Resource
    Electronic Resource
    Brainstem auditory evoked potentials in tuberous sclerosis (1993)
    Springer
    Neurological sciences 14 (1993), S. 311-316 
    Details
    ISSN: 1590-3478
    Keywords: Tuberous sclerosis ; Bourneville disease ; brainstem auditory evoked potentials ; visual evoked potentials ; Down syndrome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario Sono stati registrati i potenziali evocati auditivi troncoencefalici in 4 soggetti con sclerosi tuberosa, in uno di essi sono stati registrati anche i potenziali evocati visivi da pattern reversal. Sono state ritrovate alterazioni delle risposte (assenza o ritardo di alcune componenti ed intervalli interpicco prolungati) che possono suggerire l'esistenza di una conduzione nervosa alterata anche a livello del tronco dell'encefalo nei pazienti con sclerosi tuberosa.
    Notes: Abstract Brainstem auditory evoked potentials were recorded in 4 subjects and pattern reversal evoked potentials in 1 subject, all with tuberous sclerosis. Alterations were found (absence or delay of components and prolonged interpeak intervals) which may suggest impaired nervous conduction also at brainstem level in patients with tuberous sclerosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02339297
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  • 7
    Electronic Resource
    Electronic Resource
    Age, sex and mental retardation related changes of brainstem auditory evoked potentials in Down's syndrome (1995)
    Springer
    Neurological sciences 16 (1995), S. 377-383 
    Details
    ISSN: 1590-3478
    Keywords: brainstem auditory evoked potentials ; Down's syndrome ; age ; sex ; mental retardation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario I potenziali evocati auditivi tronco-encefalici (BAEP), registrati in 51 pazienti con sindrome di Down (SD), sono stati messi a confronto con quelli ottenuti in 38 soggetti normali di controllo. In seguito è stata valutata la correlazione tra i parametri dei BAEP con l'età, il sesso e il grado di ritardo mentale. I pazienti con SD mostravano una riduzione significativa della latenza e dell'ampiezza dell'onda V e della lunghezza dell'intervallo I–V, rispetto ai controlli. Una ulteriore riduzione età correlata dell'intervallo I–V è stata osservata nei pazienti con SD; questa è stata interpretata come il risultato di modificazioni dei meccanismi inibitori/eccitatori centrali. Le femmine con SD presentavano un intervallo I–V più breve di quello dei maschi in maniera più evidente che nella popolazione normale. Inoltre, i pazienti con ritardo mentale più grave mostravano un intervallo I–V significativamente più prolungato di quelli con ritardo mentale medio; questo potrebbe essere dovuto alla presenza di anomalie strutturali aggiuntive nei soggetti più compromessi.
    Notes: Abstract Brainstem auditory evoked potentials (BAEPs) were recorded in 51 Down's syndrome (DS) subjects and compared with those of 38 normal controls; the correlations between the BAEP measures and age, sex, and degree of mental retardation were then evaluated. The DS patients showed a significant reduction in wave V latency and amplitude and in I–III, III–V, and I–V interpeak intervals. An age-related shortening of the I–V interpeak interval found in DS patients was interpreted as being a result of changes in central inhibitory/excitatory mechanisms. In both groups, female subjects presented an I–V interval shorter than that of males but this difference was greater in the DS subjects than in the normal population. The DS patients with severe mental retardation showed significantly longer I–V interpeak intervals than those with moderate retardation; this could be due to the presence of additional central nervous system abnormalities.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02229173
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  • 8
    Electronic Resource
    Electronic Resource
    Evoked spikes and giant somatosensory evoked potentials in a patient with fragile-X syndrome (1994)
    Springer
    Neurological sciences 15 (1994), S. 365-368 
    Details
    ISSN: 1590-3478
    Keywords: fragile-X syndrome ; benign epilepsy with centrotemporal spikes ; evoked spikes ; giant somatosensory evoked potentials
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario Descriviamo il caso di un bambino di 7 anni affetto da sindrome del cromosoma X fragile ed epilessia. L'osservazione di potenziali epilettiformi rolandici durante il sonno, di punte rolandiche evocate dalla percussione della mano destra e di potenziali evocati somatosensoriali giganti, in questo paziente, fornisce unulteriore supporto alle somiglianze neurofisiologiche, già ipotizzate, tra sindrome del cromosoma X fragile ed epilessia a punte centrotemporali.
    Notes: Abstract We report the case of a 7 year old boy with fragile-X syndrome and epilepsy. In this patient, the detection of rolandic epileptiform potentials during sleep and hand tapping-evoked rolandic EEG spikes, together with giant somatosensory evoked potentials, further support the already suggested neurophysiological similarities between fragile-X syndrome and benign childhood epilepsy with centrotemporal spikes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02339934
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  • 9
    Electronic Resource
    Electronic Resource
    Seizures in Klinefelter's syndrome: A clinical and EEG study of five patients (1995)
    Springer
    Neurological sciences 16 (1995), S. 231-238 
    Details
    ISSN: 1590-3478
    Keywords: Klinefelter's syndrome ; epilepsy ; epileptiform EEG abnormalities ; genetics ; brain imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario In questo studio sono riportati 5 pazienti con sindrome di Klinefelter e crisi epilettiche o anomalie parossistiche all'EEG. In 4 soggetti il cariotipo era 47,XXY mentre in uno esso era 47,XXY/46,XX. L'età dei pazienti era compresa tra 13 e 25 anni; tutti sono stati seguiti nel tempo da un punto di vista clinico ed EEGrafico. Due pazienti erano affetti da epilessia, uno aveva presentato una crisi generalizzata tonico-clonica isolata, uno aveva presentato convulsioni febbrili e uno mostrava solo anomalie parossistiche focali all'EEG senza aver mai apparentemente presentato crisi. In due pazienti è stato possibile classificare l'epilessia (epilessia dell'infanzia a parossismi occipitali ed epilessia generalizzata criptogenetica o sintomatica). Sebbene il pattern elettroclinico nei nostri pazienti sembri piuttosto eterogeneo, è possibile inferire una certa benignità del quadro epilettologico nella sindrome di Klinefelter.
    Notes: Abstract In this study, we report the cases of five unrelated patients with Klinefelter's syndrome and seizures or EEG epileptiform abnomalities; the karyotype was 47,XXY in four, and 47,XXY/46,XX in one. They were aged 13–25 years and followed up both clinically and by means of EEG. Two of the patients had epilepsy, one had only one isolated generalized tonic-clonic seizure, one had febrile convulsions and one presented focal epileptiform EEG abnormalities without seizures. In two of the patients, it was possible to classify the epilepsy (childhood epilepsy with occipital paroxysms and cryptogenic or symptomatic generalized epilepsy). Although the electroclinical patterns appeared to be rather heterogeneous in our patients, it is possible to infer the relative good evolution of seizures in Klinefelter's syndrome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02282994
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  • 10
    Electronic Resource
    Electronic Resource
    Sleep Apnea in a patient with Becker Muscular Dystrophy (1997)
    Springer
    Neurological sciences 18 (1997), S. 59-60 
    Details
    ISSN: 1590-3478
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02106234
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