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  • 1
    Electronic Resource
    Electronic Resource
    Cognitive and motor performance in multiple system atrophy and Parkinson's disease compared
    Amsterdam : Elsevier
    Neuropsychologia 31 (1993), S. 207-210 
    Details
    ISSN: 0028-3932
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Psychology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0028-3932(93)90048-5
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  • 2
    Electronic Resource
    Electronic Resource
    Branched-chain amino acids in the treatment of amyotrophic lateral sclerosis (1989)
    Springer
    Journal of neurology 236 (1989), S. 445-447 
    Details
    ISSN: 1432-1459
    Keywords: Amyotrophic lateral sclerosis ; Branched chain amino acids ; Glutamate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Thirty-two patients affected by amyotrophic lateral sclerosis (ALS) were included in a controlled, open therapeutic trial with branched chain amino acids (BCAA). Patients with bulbar muscle involvement were evaluated separately. No statistically significant differences were found in the clinical outcome between the patients treated and the control groups. Blood l-glutamate levels measured in eight patients were normal. The failure of BCAA in the treatment of the patients could be due to different disorders with unpredictable outcome included under the diagnosis of ALS.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00328503
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Progression of motor and cognitive impairment in Parkinson's disease (1995)
    Springer
    Journal of neurology 242 (1995), S. 535-540 
    Details
    ISSN: 1432-1459
    Keywords: Parkinson's disease Dementia ; Stable parkinsonism ; Mental deterioration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We performed a longitudinal study (mean follow-up 86.7 months) to evaluate motor and mental deterioration in patients with Parkinson's disease. Of the original 91 patients, only 61 could be re-examined 7 years later and 11 of these had become demented (PD-Dems). PD-Dems were older with worse motor and, obviously, cognitive performance than non-demented parkinsonian patients (PDs). A global cognitive decay index (DI) was calculated for each patient. Based on this, non-demented PDs were further split into 38 stable parkinsonian patients (S-PDs) with DI -30% to +30%, and 10 deteriorated but non-demented parkinsonian patients (D-PDs) with a DI worse than -30% (as had PD-Dems). D-PDs were older and had greater motor impairment than S-PDs but did not differ from PD-Dems on these measures. D-PDs and PD-Dems deteriorated especially in attention, visuospatial and executive ability tests. Ageing seems to be the main predictive factor for mental deterioration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00867426
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Multiple system atrophy. Clinical and MR observations on 42 cases (1993)
    Springer
    Neurological sciences 14 (1993), S. 211-216 
    Details
    ISSN: 1590-3478
    Keywords: Multiple system atrophy ; Shy-Drager syndrome ; striatonigral degeneration ; olivopontocerebellar atrophy ; magnetic resonance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario In base a precisi criteri clinici 42 pazienti furono riconosciuti affetti da atrofia multisistemica (MSA) probabile o possibile. Venti pazienti presentavano parkinsonismo e atassia cerebellare; in 9 fu fatta diagnosi di degenerazione strio-nigrica (SND) e in altri 13 di atrofia olivopontocerebellare (OPCA). Tutti i pazienti furono sottoposti a risonanza magnetica 0.5 e/o 1.5 T. La RM mostrava alterazioni nei putamen nei 9 pazienti con SND e alterazioni in fossa posteriore come attese nell'OPCA nei 13 casi diagnosticati affetti da OPCA. In 10 dei 20 pazienti con parkinsonismo e atassia cerebellare le alterazioni nei putamen e in fossa posteriore erano associate. I nostri dati confermano che la RM è un supporto diagnostico fondamentale nella diagnosi di MSA.
    Notes: Abstract Probable or possible multiple system atrophy (MSA) was diagnosed on strict clinical criteria in 42 patients: 20 with combined parkinsonism and cerebellar ataxia, 9 with striatonigral degeneration (SND) and 13 with olivopontocerebellar atrophy (OPCA). All patients were then studied with 0.5 and/or 1.5 Tesla magnetic resonance (MR) units. MR imaged putaminal abnormalities in all 9 patients with SND and posterior fossa obnormalities consistent with OPCA in all 13 patients with this diagnosis. Of the 20 patients with parkinsonism and cerebellar involvement, classified as probable MSA, 7 presented putaminal abnormalities only, 3 abnormalities consistent with OPCA only and 10 a combination of both. These findings show strong MRI support for the clinical diagnosis of MSA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02335661
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  • 5
    Electronic Resource
    Electronic Resource
    Clinical and neuroradiological aspects of Sneddon's syndrome and primary antiphospholipid antibody syndrome. A follow-up study (2000)
    Springer
    Neurological sciences 21 (2000), S. 157-164 
    Details
    ISSN: 1590-3478
    Keywords: Key words Sneddon's syndrome ; Primary antiphospholipid syndrome ; Differential diagnosis ; Prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We performed a study to investigate differences and similarities between patients with Sneddon's syndrome and those with primary antiphospolipid syndrome (PAS), by clinical follow-up, magnetic resonance imaging (MRI) and angiography. Nine patients with Sneddon's syndrome and 11 patients with PAS were assessed at diagnosis and followed for a mean fo 6 years. The clinical and MRI findings indicated that Sneddon's syndrome and PAS are distinct entities. Patients with Sneddon's syndrome had a progressive clinical course with increasing disability and cognitive deterioration; patients with PAS had a more benign course. Infarcts in territories of the main cerebral arteries were frequent in PAS, while leukoaraiosis and smaller lacunar infacts were more comon in Sneddon's syndrome. In 3 of 7 women initially diagnosed with PAS, the diagnosis was changed to systemic lupus erythematosus during follow-up. Differential diagnosis of Sneddon's syndrome and PAS is important, as early therapy is effective for the latter, more benign, condition.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100720070091
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    Paper (German National Licenses)
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