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  • 1
    Electronic Resource
    Electronic Resource
    Algebraic structures and invariant manifolds of differential systems (1998)
    College Park, Md. : American Institute of Physics (AIP)
    Journal of Mathematical Physics 39 (1998), S. 2929-2946 
    Details
    ISSN: 1089-7658
    Source: AIP Digital Archive
    Topics: Mathematics , Physics
    Notes: Algebraic tools are applied to find integrability properties of ODEs. Bilinear nonassociative algebras are associated to a large class of polynomial and nonpolynomial systems of differential equations, since all equations in this class are related to a canonical quadratic differential system: the Lotka–Volterra system. These algebras are classified up to dimension 3 and examples for dimension 4 and 5 are given. Their subalgebras are associated to nonlinear invariant manifolds in the phase space. These manifolds are calculated explicitly. More general algebraic invariant surfaces are also obtained by combining a theorem of Walcher and the Lotka–Volterra canonical form. Applications are given for Lorenz model, Lotka, May–Leonard, and Rikitake systems. © 1998 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.532429
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  • 2
    Electronic Resource
    Electronic Resource
    Temporal arteritis presenting with scalp ulceration (2002)
    Oxford, UK : Blackwell Science Ltd
    Journal of the European Academy of Dermatology and Venereology 16 (2002), S. 0 
    Details
    ISSN: 1468-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We report the case of a 75-year-old-woman who presented with bilateral scalp ulcerations and blindness, accompanied by severe headache and scalp tenderness, due to bilateral temporal arteritis without systemic involvement. A biopsy taken from the border of an ulceration showed evidence of giant cell arteritis. She was treated with oral prednisone, 60 mg per day. The ulcerations healed in a few weeks but the vision loss was irreversible. This case highlights for temporal arteritis the importance of accurate and timely diagnosis as well as the need for prompt therapy with systemic steroids in order to avoid major complications, namely loss of vision. It also demonstrates that scalp necrosis and ulcerations are skin signs associated with a poor prognosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1468-3083.2002.00594.x
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  • 3
    Electronic Resource
    Electronic Resource
    FS09.5
Patch testing with allopurinol and oxypurinol in drug eruptions (2004)
    Oxford, UK; Malden, USA : Blackwell Publishing Ltd/Inc.
    Contact dermatitis 50 (2004), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background:  Drug eruptions as maculopapular rash, hypersensitivity syndrome, Stevens-Johnson syndrome or toxic epidermal necrolysis occur in about 2% of patients taking allopurinol. The allopurinol oxidation product – oxypurinol – seems to be responsible for these hypersensitivity reactions. Opposing what occurs during the study of drug eruptions induced by other drugs as carbamazepine or amoxiciline, patch testing with allopurinol is usually negative.Objective:  To evaluate skin reactivity to allopurinol and oxypurinol by patch testing in patients with a previous history of drug eruption related with allopurinol.Methods:  10 patients (6 females and 4 males) with drug eruptions induced by allopurinol with a high imputability index (6 hypersensitivity syndromes, 2 Stevens-Johnson syndromes, 1 erythroderma and 1 toxic epidermal necrolysis) were patch tested with allopurinol in vaseline (10 and 20%) and with oxypurinol in vaseline (10 and 20%), acetone (10 and 20%) and alcohol (10 and 20%).Results:  Patch tests with allopurinol and oxypurinol were invariably negative after 48 and 96 hours in all patients tested.Conclusion:  Patch testing with oxypurinol as well as with allopurinol is usually negative and therefore is not helpful in the confirmation of these hypersensitivity reactions to allopurinol.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0105-1873.2004.0309ch.x
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  • 4
    Electronic Resource
    Electronic Resource
    Photosensitivity to piroxicam: absence of cross-reaction with tenoxicam (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 27 (1992), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We studied 2 groups of patients. One group or 10 patients had a photosensitive eruption to piroxicam. Another group of 24 patients had positive patch test reactions to thimerosal and thiosalicylie acid and had never taken piroxicam or tenoxicam. Patients were patch tested with thimerosal 0.1% pet., thiasalicylic acid 0.1% pet., salicylic acid 2.0% pet., piroxicam 1 and 5% pet. and tenoxicam 1 and 5% pet. photopatch tests were also performed with piroxicam and tenoxicam. All 10 patients with photosensitivity to piroxicam had positive patch tests to thiosalicylic and thiosalicylic acid and 9 of them had positive photopatch tests to ptroxicam. 20 out of 24 patients with positive patch tests to thiosalicylic acid also had positive photopatch tests to Piroxicam. All the patients tested with salicylic add were negative. Out of the 29 patients with positive photopatch tests to piroxicam, none reacted to tenoxicam. In countries with a high incidence of contact sensitivity to thimerosal/thiosalicylic acid, the use of piroxicam should be avoided and replaced by tenoxicam, a drug without reported photosensitivity
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0536.1992.tb03281.x
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  • 5
    Electronic Resource
    Electronic Resource
    P32
Dexamethasone inhibits dendritic cell activation by skin sensitizers (2004)
    Oxford, UK; Malden, USA : Blackwell Science Ltd/Inc.
    Contact dermatitis 50 (2004), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective:  Evaluate activity of a corticosteroid on dendritic cell (DC) activation induced by skin sensitizers.Methods:  Using a fetal mouse skin derived dendritic cell line (FSDC) stimulated by Nickel sulphate (50–100 ìg/ml) and DNFB (1–2.5 ìg/ml), we studied the effect of dexamethasone (DEX)(0.01–1 ìM) on nitric oxide (NO) production (by the Griess reaction), on nitric oxide synthase type II expression (iNOS)(by immunocytochemistry and western blot) and on the activation of the nuclear factor-kappaB pathway (NF-êB)(by electrophoretic mobility shift assay – EMSA), pathways that we have previously shown to be activated by these sensitizers.Results:  NO production induced by Ni was significantly inhibited by DEX in a dose dependent way. Future studies using 0.5 ìM of DEX, showed a significant reduction of iNOS expression at 24 h induced by both sensitizers. This effect occurred in parallel with the inhibition of NF-êB activation, which was most evident at 45 min.Conclusions:  These results suggest that dexamethasone inhibits intracellular events that are relevant for DC activation induced by skin sensitizers during antigen presentation. Therefore, besides the anti-inflammatory activity of DEX usually used for the treatment of ACD, this drug can also interfere with the initial steps of skin sensitization. This work was supported by FCT (Portugal).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0105-1873.2004.0309fn.x
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  • 6
    Electronic Resource
    Electronic Resource
    P60
Permeability of gloves to plant allergens (2004)
    Oxford, UK; Malden, USA : Blackwell Science Ltd/Inc.
    Contact dermatitis 50 (2004), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective:  Study permeability of gloves to plant allergens, therefore evaluating glove efficacy for hand protection.Material and methods:  We studied 20 female patients (aged 21–71; mean 45,1 years) with ACD from plants, 10 allergic to diallyl disulfide (DAD) from Allium sativa, 8 allergic to alpha-methylene-gama-butyrolactone (AMGBL) from Alstroemeria ligtu and 2 allergic to primin from Primula obconica. Patch testing was performed applying the allergens, for 24 or 48 h, directly on the skin and over fragments of different gloves: domestic rubber gloves (RG), nitrile latex gloves (NG), vinyl gloves (VG), surgical latex gloves (LG) and polyethylene gloves (PG).Results:  VG, PG or LG gloves offered no protection for these 3 allergens. With RG and NG gloves, DAD reactivity was abolished or significantly reduced, respectively, in 5 and 7 cases. Reactivity to AMGBL wasn’t abolished by any glove material. NG abolished skin reactivity to primin; RG was efficacious only in 1 patient.Conclusions:  Advising gloves in patients with ACD from plants is difficult, as allergen permeability through gloves associated with occlusion may intensify the dermatitis, as occurred during skin testing. Nitrile latex gloves may protect from primin and garlic dermatitis, whereas they are not helpful for manipulating Alstroemeria. Although exposure time in this study is higher than in real life, results show interesting data on glove permeability to these plant allergens and support our patients’ complaints that gloves didn’t protect them.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0105-1873.2004.0309gp.x
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  • 7
    Electronic Resource
    Electronic Resource
    The inflammatory response in mild and in severe psoriasis (2004)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 150 (2004), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background  Psoriasis is a chronic and recurrent inflammatory skin disease. The inflammatory response represents a fundamental ability of the organism to protect itself from infectious agents and from injury.Objectives  To evaluate the inflammatory response in mild and in severe psoriasis, to evaluate the endogenous systems counterbalancing the deleterious effects of the inflammation products, and to establish values of prognostic significance.Methods  The study was performed in a control group (n = 40) and in 60 patients with psoriasis vulgaris, half presenting with mild psoriasis, and the other half with severe psoriasis. We evaluated total and differential leucocyte count; elastase, lactoferrin and lipid peroxidation as markers of neutrophil activation; total plasma antioxidant capacity (TAS), transferrin, ceruloplasmin, α1-antitrypsin and α2-macroglobulin as markers of the endogenous antioxidant and antiprotease systems; and fibrinogen, erythrocyte sedimentation rate, C-reactive protein (CRP), haptoglobin, C3 and C4 complement proteins as markers of inflammation.Results  Our data suggested that psoriasis is an inflammatory condition in which neutrophils seem to play a crucial role by contributing to the development of oxidative and proteolytic stress. The worsening of the disease seemed to be linked to the enhancement of the inflammatory response and of the imbalance between neutrophil activation products and their inhibitors.Conclusions  We propose values for elastase, CRP, elastase/α2-macroglobulin, elastase/α1-antitrypsin, thiobarbituric acid/TAS and elastase/neutrophil ratios with prognostic significance for the worsening of psoriasis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.2004.05984.x
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  • 8
    Electronic Resource
    Electronic Resource
    Experimental studies on the mechanisms of tiaprofenic acid photosensitization
    Amsterdam : Elsevier
    Journal of Photochemistry and Photobiology B: Biology 18 (1993), S. 161-168 
    Details
    ISSN: 1011-1344
    Keywords: Free radicals ; Histidine test ; Photohaemolysis ; Photosensitization ; Phototoxicity ; Singlet oxygen ; Tiaprofenic acid
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/1011-1344(93)80058-H
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  • 9
    Electronic Resource
    Electronic Resource
    Sand ridges on the inner Atlantic shelf of North America: Morphometric comparisons with Huthnance stability model (1981)
    Springer
    Geo-marine letters 1 (1981), S. 187-191 
    Details
    ISSN: 1432-1157
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract Sand ridge fields on the inner shelf of the Middle Atlantic Bight are generally thought to have formed in response to northeasterly storm flows as the shoreface underwent erosional retreat with postglacial sea-level rise. However, the hydrodynamic mechanism is poorly unerstood. Coastal boundary models see the ridges as responses of the seafloor to distortions in the flow induced by the coastal boundary. Stability models propose that an irregular initial topography will evolve toward an ordered array of bedforms in response to repeated flow events. The two classes of models are not mutually exclusive, nor are members within each class mutually exclusive. Results of measurements of ridge spacing on the inner Atlantic shelf of North America agree with the predictions of stability models.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02462432
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  • 10
    Electronic Resource
    Electronic Resource
    Preferential settling of smectite on the Amazon continental shelf (2000)
    Springer
    Geo-marine letters 20 (2000), S. 37-42 
    Details
    ISSN: 1432-1157
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract Seventy-five surface and subsurface sediment samples collected on the Amazon continental shelf were analyzed by X-ray diffraction (XRD) in the grain-size fractions smaller than 2 μm. The groups of clay minerals thus identified were smectite, kaolinite, illite, and mixed-layer illite/smectite. Calculation of relative abundance shows a predominance of smectite (37%) in the whole area, followed by kaolinite (27%), illite (23%), and a small percentage of mixed-layer illite/smectite (12%). The distal, northwest region of the continental shelf is characterized by a high abundance of smectite (41%), high salinity values, and high sediment accumulation rates (10 cm year−1), whereas the proximal region is characterized by a comparatively low abundance of smectite (30%), low salinity values, and low sediment accumulation rates (〈1 cm year−1). This trend of increasing abundance northwestwards documents a preferential settling of smectite in the distal and more saline regions of this estuarine system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003670000035
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