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  • 1
    Electronic Resource
    Electronic Resource
    ENDOTHELIAL PROGENITOR CELLS * (2005)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Medicine 56 (2005), S. 79-101 
    Details
    ISSN: 0066-4219
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine
    Notes: Endothelial progenitor cells are a circulating, bone marrowĐ??derived cell population that appears to participate in both vasculogenesis and vascular homeostasis. Questions persist regarding their functional characteristics, as well as the precise panel of cell surface markers that uniquely define this newly described progenitor cell population. We review experimental results obtained from both animal studies and recent clinical trials that suggest this cell type may have tremendous therapeutic potential for a wide range of human diseases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.med.56.090203.104149
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  • 2
    Electronic Resource
    Electronic Resource
    Stem cell aging: what bleach can teach (2006)
    [s.l.] : Nature Publishing Group
    Nature medicine 12 (2006), S. 383-384 
    Details
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Late-night infomercials are filled with advertisements for dietary supplements that claim to be rich in natural antioxidants. Often, a well-tanned announcer encourages the viewer to purchase—in three easy installments—an all-natural way to live longer by fighting the body's harmful free ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nm0406-383
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  • 3
    Electronic Resource
    Electronic Resource
    Cancer gets the Chk'ered flag (2006)
    [s.l.] : Nature Publishing Group
    Nature medicine 12 (2006), S. 1354-1356 
    Details
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] The discovery of human tumor oncogenes in the early 1980s and the subsequent realization of the existence of tumor suppressors seemed to turn a number of cancer biologists into overeducated automobile mechanics. Oncogenes became the cell's stuck accelerator pedal and tumor suppressors were the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nm1206-1354
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  • 4
    Electronic Resource
    Electronic Resource
    Oxidants, oxidative stress and the biology of ageing (2000)
    [s.l.] : Macmillan Magazines Ltd.
    Nature 408 (2000), S. 239-247 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Living in an oxygenated environment has required the evolution of effective cellular strategies to detect and detoxify metabolites of molecular oxygen known as reactive oxygen species. Here we review evidence that the appropriate and inappropriate production of oxidants, together with the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/35041687
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  • 5
    Electronic Resource
    Electronic Resource
    Ageing and the mystery at Arles (2004)
    [s.l.] : Nature Publishing Group
    Nature 429 (2004), S. 149-152 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] “I don't want to achieve immortality through my work. I want to achieve it through not dying” — Woody Allen (1935–?) In August 1997, Jeanne Calment was laid to rest in a simple ceremony in the south of France. Those who eulogized her life that day noted that it was ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/429149a
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  • 6
    Electronic Resource
    Electronic Resource
    Pharmacology Uncoupling the agony from ecstasy (2003)
    [s.l.] : Nature Publishing Group
    Nature 426 (2003), S. 403-404 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The recreational use of amphetamine-type stimulants can produce a marked and sometimes lethal increase in body temperature. Here we show that mice deficient in a mitochondrial protein known as UCP-3 (for 'uncoupling protein-3') have a diminished thermogenic response to the drug MDMA ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/426403a
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  • 7
    Electronic Resource
    Electronic Resource
    Ageing A toast to long life (2003)
    [s.l.] : Nature Publishing Group
    Nature 425 (2003), S. 132-133 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] In the spring of 1512, three wooden vessels commanded by the Spanish explorer Ponce de León left the warm Caribbean waters off Puerto Rico in search of the fountain of youth. Fuelled by his desire for immortality, Ponce de León was convinced that drinking from this legendary spring ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/425132a
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  • 8
    Electronic Resource
    Electronic Resource
    The common biology of cancer and ageing (2007)
    [s.l.] : Nature Publishing Group
    Nature 448 (2007), S. 767-774 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] At first glance, cancer and ageing would seem to be unlikely bedfellows. Yet the origins for this improbable union can actually be traced back to a sequence of tragic—and some say unethical—events that unfolded more than half a century ago. Here we review the series of key ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nature05985
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  • 9
    Electronic Resource
    Electronic Resource
    Cell biology A clean energy programme (2006)
    [s.l.] : Nature Publishing Group
    Nature 444 (2006), S. 151-152 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Climate scientists have taught us that the planet is getting warmer because of the intimate relationship between the production and consumption of energy and the consequent generation of toxic by-products. Cell biologists have long known that a similar struggle between product and by-product occurs ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/444151a
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  • 10
    Electronic Resource
    Electronic Resource
    Fertilization in the sea urchin arbacia punctulata inhibited by fluorescein dyes: Evidence for a plasma membrane mechanism (1981)
    New York, NY : Wiley-Blackwell
    Gamete Research 4 (1981), S. 219-229 
    Details
    ISSN: 0148-7280
    Keywords: fertilization ; sea urchin ; Arbacia punctulata ; Erythrosin B ; dyes ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: Fertilization and ionophore activation of the sea urchin Arbacia punctulata were inhibited in the presence of six analogs of the dye fluorescein. The concentration of any one dye needed for blockage of sperm or Ca-ionophoremediated activation in 50% of the eggs (I50) was a function of the dye's lipid solubility. Substantially higher concentrations of each dye were required to block activation by Ca-ionophore (A23187) than were needed to inhibit sperm activation. A detailed study of the action of Erythrosin B (tetraiodofluorescein) showed that its effects were readily reversible. The I50 concentration of Erythrosin B increased as temperature increased from 10 to 25°C. The kinetics of blockage indicated that Erythrosin B blocked some early step in the program of fertilization. The results suggest that these anionic dyes may inhibit fertilization by preventing successful sperm-egg fusion.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mrd.1120040306
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