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Digitale Medien

Clinical pharmacokinetics of suramin in patients with onchocerciasis (1998)

Chijioke, C. P. ; Umeh, R. E. ; Mbah, A. U. ; [weitere]

Springer

European journal of clinical pharmacology 54 (1998), S. 249-251

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Details

ISSN: 1432-1041

Schlagwort(e): Key words Suramin ; Onchocerciasis

Quelle: Springer Online Journal Archives 1860-2000

Thema: Chemie und Pharmazie , Medizin

Notizen: Abstract Objective: Ten male patients with onchocerciasis received six weekly infusions of suramin according to the WHO-recommended regimen. Results: In no case did the plasma concentration of suramin exceed 300 mg · l−1, and serious toxicity was not observed. The apparent volume of distribution (median 20.6 l) was comparable to that reported for patients with prostatic carcinoma. Elimination from patients with onchocerciasis was relatively slow (median plasma clearance 6.2 ml · h−1, median terminal elimination half-life 91.8 days). Conclusion: Microfilariae were eliminated in eight out of ten patients. Spontaneous nodule regression was noted in four patients.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/s002280050454

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