ISSN:
1573-6903
Keywords:
Translational inhibitor
;
LSD
;
heat shock protein
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Inhibition of brain protein synthesis following intravenous administration of d-lysergic acid diethylamide (LSD) is accompanied by generation of a translational inhibitor protein in the postribosomal supernatant of cerebral hemispheres. Addition of an enriched preparation of this factor to a brain cell-free translation system resulted in a selective reduction in the level of phosphorylation of proteins of molecular weight 55K, 41K, and 25K. A similar set of changes was also observed in a brain cell-free system prepared 1 hr subsequent to drug injection. The brain inhibitor reduced the translational capacity of a messenger RNA-dependent reticulocyte lysate programmed with brain polysomes isolated from saline-injected animals however little effect was apparent when polysomes were prepared from LSD-treated animals. The translational inhibitor did not affect the spectrum of translation products from either set of polysomes.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00993239
Permalink
