ISSN:
1573-8353
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract Routes for the synthesis of 3-deoxypyridoxal 5-phosphate were studied, and a method for its preparation by the transamination of 3-deoxypyridoxamine 5-phosphate is proposed. Chlorination and reduction of 6-methyl-4-methoxymethyl-3-cyano-2-pyridone converted it to 2-methyl-4-methoxymethyl-5-aminomethylpyridine dihydrochloride which, without isolation, was successively treated with HBr, diazotized, and animated. The mixture of amines obtained was phosphorylated with polyphosphoric acid, and the phosphate was separated by chromatography. The UV, IR, and PMR spectra of the compounds obtained were investigated.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00471484
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