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  • 1
    Digitale Medien
    Digitale Medien
    Long-term Potentiation of NMDA Receptor-mediated EPSP in Guinea-pig Hippocampal Slices (1991)
    Oxford, UK : Blackwell Publishing Ltd
    European journal of neuroscience 3 (1991), S. 0 
    Details
    ISSN: 1460-9568
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Hippocampal slices from guinea-pigs were used to examine the long-term potentiation (LTP) of the N-methyl-D-aspartate (NMDA)-mediated excitatory postsynaptic potential (EPSP). lntracellular recordings were performed from CA1 pyramidal neurons in the presence of 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX, 5–10 μM) and picrotoxin (50 μM). In these experimental conditions test stimuli applied at low frequency (0.1 Hz) to the Schaffer collateral - commissural pathway evoked a prolonged EPSP (150–200 ms). To obtain this CNQX-resistant EPSP, stimulus intensities had to be raised above the level required to evoke an EPSP of comparable amplitude in physiological solution. Tetanic stimulation (two trains of 100 Hz, 1 s every 20 s) led to a potentiation of the CNQX-resistant EPSP, and this potentiated response was abolished with d-(-)-2-amino-5-phosphonovaleric acid (50μM). The potentiation of the NMDA receptor-mediated EPSP was more pronounced for strong than for weak test stimuli, and was suppressed when test EPSPs were evoked during membrane hyperpolarization. These results suggest that NMDA receptor-mediated responses can undergo LTP, and hence can contribute to the maintenance of LTP.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1460-9568.1991.tb00096.x
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  • 2
    Digitale Medien
    Digitale Medien
    Mapping of functional activity in the falcon visual system with [14C] 2-Deoxyglucose (1984)
    Springer
    Experimental brain research 53 (1984), S. 217-222 
    Details
    ISSN: 1432-1106
    Schlagwort(e): Falcon ; Visual system ; [14C] 2-Deoxyglucose
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary [14C] 2-Deoxyglucose uptake was mapped in the brain of one awake falcon which had one eye covered during the experiment, with the aim of providing tentative data on the identification of this bird's visual centers. Most of the structures with increased [14C] 2-Deoxyglucose uptake receive information from the exposed eye. Labeling was rather symmetrical in the hyperstriatum which receives bilateral projections from the visual thalamic centers. The results are largely consistent with what is known about the visual pathways in pigeons and owls. The falcon's visual Wulst as detected by the [14C] 2-Deoxyglucose labeling, is proportionally larger than that found in the pigeon. This result is consistent with the marked representation of the binocular visual field in the falcon's Wulst.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00238151
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  • 3
    Digitale Medien
    Digitale Medien
    Effects of dopamine, D-1 and D-2 dopaminergic agonists on the excitability of hippocampal CA1 pyramidal cells in guinea pig (1990)
    Springer
    Experimental brain research 83 (1990), S. 124-130 
    Details
    ISSN: 1432-1106
    Schlagwort(e): Dopamine ; D-1 and D-2 agonists ; Afterhyperpolarization ; Hippocampal slices ; Guinea pig
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary In hippocampal pyramidal cells (HPCs), Dopamine (DA) application (1 μM) produced, in 50% of recorded cells, an hyperpolarization of the resting membrane potential (r.m.p.) and an increase of the afterhyperpolarization (AHP) amplitude and duration in 79% of recorded cells. DA-induced effects on both the r.m.p. and AHP were mimicked by bath application of a D-l selective agonist, SKF 38393 (20 μM). In addition, we have observed that a D-l selective antagonist such as SCH 23390 (1 μ,M) abolished the action of both DA and SKF 38393. In contrast, the activation of D-2 receptors through LY 171555 (10 μm) produced, in 50% of cells, a depolarization of the r.m.p. and a depression of the AHP in 67% of recorded cells. These results suggest that the effects observed in hippocampal pyramidal neurons after DA application of micromolar concentration are mediated by D-1 subtype of receptors.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00232200
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  • 4
    Digitale Medien
    Digitale Medien
    Pigeon pattern electroretinogram: A response unaffected by chronic section of the optic nerve (1984)
    Springer
    Experimental brain research 55 (1984), S. 253-262 
    Details
    ISSN: 1432-1106
    Schlagwort(e): ERG ; Gratings ; Optic nerve ; Retina ; Pigeon
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Retinal evoked responses to sinusoidal gratings modulated in counterphase (pattern ERG) have been recorded from the pigeon eye. The pattern ERG amplitude depends upon the temporal frequency of the modulation, the contrast, the spatial frequency and the area of the stimulus. In 8 pigeons the pattern ERG has been recorded at different times after the unilateral section of the optic nerve. It has been found that the pattern ERG has a comparable amplitude in the two eyes as a function of the spatial frequency, 3 and 9 months after the section of the left optic nerve. At these times, histological evidence shows a drastic reduction in the density of the retinal ganglion cells on the operated side in comparison to the control one. These findings suggest that retinal sources other than the ganglion cells are responsible for the generation of the pigeon pattern ERG.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00237276
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  • 5
    Digitale Medien
    Digitale Medien
    The pigeon pattern electroretinogram is not affected by massive loss of cell bodies in the ganglion layer induced by chronic section of the optic nerve (1985)
    Springer
    Documenta ophthalmologica 61 (1985), S. 41-47 
    Details
    ISSN: 1573-2622
    Schlagwort(e): alternating gratings ; electroretinogram ; ganglion cells ; pigeon
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract In pigeons, electroretinographic responses to contrast reversal of sinusoidal gratings (pattern ERGs) were recorded before and after section of the left optic nerve. Ninety and 270 days following optic nerve section the ganglion cell layer of the side that underwent the surgical procedure showed an 80% reduction in the number of cell bodies as compared with the intact side. At these times the pattern ERGs showed comparable amplitudes in both eyes. There is a possibility that the inner nuclear layer of the pigeon retina plays a major role in the generation of the pattern ERG.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00143214
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