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  • 1
    Electronic Resource
    Electronic Resource
    HIGH FREQUENCY OF Mlsa-REACTIVITY AMONG Ab-RESTRICTED, H-Y-SPECIFIC T CELL CLONES (1988)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 15 (1988), S. 0 
    Details
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: A high frequency (80%) of Ab-restricted, H-Y-specific T cell clones, but not of Ab-restricted LDH-B-specific T cell clones, was found to be Mlsa-reactive. This reactivity could be inhibited by class II (A and E)-specific antibodies, and required an E-positive stimulator cell. The proliferation was also blocked by T cell receptor-specific and by CD4-specific antibodies. Possible interpretations of these findings are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1744-313X.1988.tb00412.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    ANTI-MHC IMMUNITY DETECTED PRIOR TO INTENTIONAL ALLOIMMUNIZATION (1986)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 13 (1986), S. 0 
    Details
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Naturally occurring H-2-specific antibodies can be detected rather frequently in sera of non-alloimmunized mice by sufficiently sensitive techniques (Cerny-Provaznik et al., 1985a; Cerny-Provaznik & Ivanyi, 1985). In this report, we summarize our experiences with the preparation of monoclonal anti-H-2 antibodies obtained from hybridization experiments from non-alloimmunized mice. From a total of 30 spleen cell hybridization experiments, we could isolate only four anti-H-2 monoclonal antibodies (mAb). Two of the m Ab are described in this report. Monoclonal antibody By-2 is anti-Kf and mAb By-3 is anti-Db, D5. We investigated which conditions favour the isolation of monoclonal H-2-specific antibodies from non-alloimmunized mice. The presence of naturally occurring serum antibodies, the age of the spleen donor mouse or non-specific B cell stimulation were not critical for the isolation of natural anti-H-2 mAb. We hypothesise that the ‘natural’ H-2-specific antibodies represent compartments of the B cell repertoire which were triggered by modified or aberrant self-MHC expression.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1744-313X.1986.tb01113.x
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  • 3
    Electronic Resource
    Electronic Resource
    Identification of the Tapasin gene in the chicken major histocompatibility complex (1999)
    Springer
    Immunogenetics 49 (1999), S. 328-337 
    Details
    ISSN: 1432-1211
    Keywords: Key words Tapasin ; Chicken Mhc ; B complex ; Immunoglobulin superfamily
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract  The Tapasin molecule plays a role in the assembly of major histocompatibility complex (Mhc) class I molecules in the endoplasmic reticulum, by mediating the interaction of class I-β2-microglobulin dimers with TAP. We report here the identification of the Tapasin gene in the chicken Mhc (B complex). This gene is located at the centromeric end of the complex, between the class II B-LBI and B-LBII genes. Like its human counterpart it comprises 8 exons, but features a significantly reduced intron size as compared to the human gene. Chicken Tapasin codes for a transmembrane protein with a probable endoplasmic reticulum retention signal. Exons IV and V, and possibly exon III, code for separate domains that are related to the immunoglobulin (Ig) superfamily (this relationship was so far unrecognized for human Tapasin domain IV which has lost its two cysteines). Two different cDNAs corresponding to the Tapasin gene were isolated, possibly related to alternative splicing events; the Ig-like domain encoded by exon IV is missing in one of the cDNAs, suggesting either that this domain is not necessary for the protein to perform its function, or that the two alternatively spliced cDNAs are translated into two functionally different forms of the protein.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002510050500
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    Paper (German National Licenses)
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