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  • 1
    Electronic Resource
    Electronic Resource
    Roles of extracellular signal-regulated kinase and Akt signaling in coordinating nuclear transcription factor-κB-dependent cell survival after serotonin 1A receptor activation (2005)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 95 (2005), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: To investigate the functional consequences of cross-talk between multiple effectors of serotonin (5-HT) 1A receptor, we employed transfected Chinese hamster ovary cells. Activation of 5-HT1A receptor stimulated extracellular signal-regulated kinase (ERK)1/2, Akt and nuclear transcription factor-κB (NF-κB). Stimulation of cells with 5-HT1A receptor agonist induced a rapid but transient ERK1/2 phosphorylation followed by increased phosphorylation of Akt. Elevated Akt activity in turn suppressed Raf activity and induced a decline in ERK activation. The activation of ERK and Akt downstream of 5-HT1A receptor was sensitive to inhibitors of Ras, Raf and phosphatidylinositol 3-kinase (PI3K). Stimulation of 5-HT1A receptor also resulted in activation of NF-κB through a decrease in inhibitor of nuclear transcription factor-κB. In support of the importance of 5-HT1A receptor signaling for cell survival, inhibition of NF-κB facilitated caspase 3 activation and cleavage of poly (ADP-ribose) polymerase, while treatment of cells with agonist inhibited caspase 3, DNA fragmentation and cell death. Both agonist-dependent NF-κB activation and cell survival were decreased by Akt Inhibitor II or by overexpression of dominant-negative Akt. These findings suggest a role for 5-HT1A receptor signaling in the Ras/Raf-dependent regulation of multiple intracellular signaling pathways that include ERK and PI3K/Akt. Of these, only PI3K/Akt and NF-κB activation were required for 5-HT1A receptor-dependent cell survival, implying that the relative distribution of signals between competing transduction pathways determines the functional outcome of 5-HT1A receptor activation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.2005.03496.x
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  • 2
    Electronic Resource
    Electronic Resource
    Regulation of endothelium-derived nitric oxide production by the protein kinase Akt (1999)
    [s.l.] : Macmillan Magazines Ltd.
    Nature 399 (1999), S. 597-601 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Endothelial nitric oxide synthase (eNOS) is the nitric oxide synthase isoform responsible for maintaining systemic blood pressure, vascular remodelling and angiogenesis. eNOS is phosphorylated in response to various forms of cellular stimulation but the role of phosphorylation in the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/21218
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Apoptosis A Bad kinase makes good (1997)
    [s.l.] : Macmillan Magazines Ltd.
    Nature 390 (1997), S. 116-117 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The regulation of cell survival is a central feature in animal development and in diseases such as cancer. Results published over the past year implicate phosphoinositide 3-kinase (PI3K) and its downstream target, the serine/threonine protein kinase Akt, in a pathway that conveys survival signals ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/36442
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    Paper (German National Licenses)
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