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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 103 (1996), S. 0 
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective To assess the technical feasibility and functional results of sigmoid colon vaginoplasty using a modified technique.Design Retrospective descriptive analysis.Setting Referral centre.Patients A method for creating an artificial vagina was applied in 13 women for the following indications: true hermaphrodite (n= l), gender dysphoria (n= 2), Müllerian dysgenesis (n= 10).Interventions A method for sigmoid vaginoplasty was devised whereby transection of the inferior mesenteric artery proximal to the first sigmoid branch provides immediate mobility for the sigmoid colonic segment to reach the introitus (with adequate nourishment from the middle and inferior rectal vascular systems).Main outcome measures Assessment of sexual function after a follow up period of 1 to 19 years.Results Twelve women reported a satisfactory result. Three of these were lost to follow up after one year, and the others report for regular assessment. Mild stenosis at the muco-cutaneous anastomosis, which may occur after failed perineal procedures, appears to be amenable to daily dilatations until the women become sexually active. In one woman the prosthesis had to be removed on account of severe pelvic floor fibrosis as a result of previous abdomino-perineal surgery at the age of seven. Another woman presented with a postcoital vesico-vaginal fistula after a previous McIndoe procedure; the tear at the base of the bladder was repaired and buttressed with a sigmoid vagina which is now functioning satisfactorily after 19 years.Conclusion The creation of a sigmoid vagina which is vascularised by the middle and inferior rectal arterial systems appears to be an acceptable procedure for vaginal agenesis, acquired vaginal loss or sexual reassignment.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1434-0879
    Keywords: Calcium ; Kidney stones ; Magnesium ; Plasmin ; Sialidase ; Urokinase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of a promoter (calcium) and an inhibitior (magnesium) of urolithiasis was spectrophotometrically studied on urokinase (0.45 IU) and sialidase (5 mM). Although these mineral did not affect the sialidase activity, total inhibition of urokinase activity was observed with either 0.05 M calcium chloride or 0.1 M magnesium chloride. This observation might explain why calcium and magnesium respectively function as a promoter and an inhibitor of stone formation.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    World journal of surgery 6 (1982), S. 689-695 
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé La thyroïdectome subtotale ou le traitement par l'Iode 131 permettent d'assurer la guérison définitive de l'hyperthyroïdisme. Le choix entre les deux modalités thérapeutiques dépend du type du goître, de la gravité de l'hyperthyroïdie, du volume de la glande, de l'âge et aussi des désirs du malade. Chez le sujet jeune qui présente un volumineux goitre et une hyperthyroïdie sévère les auteurs donnent leur préférence au traitement chirurgical. Le malade est préparé par l'administration conjointe de thionamides, de béta-bloquants et de solution de Lugol de façon à parvenir à un état d'euthyroïdie. La préparation à l'aide exlusive des bétabloquants est insuffisante; elle a été suivie parfois par un “orage thyroïdien post-opératoire.”
    Notes: Abstract Either subtotal thyroidectomy or ablation of the gland with131I will lead to a permanent cure of hyperthyroidism. In choosing between these 2 modalities of treatment, several factors should be taken into account, such as the type of goiter, the severity of hyperthyroidism, the size of the gland, age, fitness, and preference of the patient. It is our practice to perform a subtotal thyroidectomy on the young patient with a large gland and severe hyperthyroidism. In the preparation of these patients, thionamides, beta-blockade, and Lugol's iodine are used together until the patient is euthyroid. Preparation with beta-blockade alone led to the only instances of impending storm after surgery in our experience.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-2218
    Keywords: Sclerotherapy ; Thrombosis ; Endothelium ; Coagulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The mechanism of thrombosis following intravariceal injection of sodium tetradecyl sulphate (S.T.D.) was investigated with respect to effects on the vascular endothelium, the coagulation cascade, and platelet function. Using an umbilical cord model designed to simulate blood flow over the endothelium, it was found that S.T.D. is a potent toxin for endothelial cells in that brief exposure to even low concentrations of the agent were effective in stripping endothelium over a considerable distance, exposing highly thrombogenic endothelium in the process. Effects on coagulation and platelet function were found to be dependent on concentration. Diluted S.T.D. induced a hypercoagulable state, possibly in consequence of a selective inhibition of the physiological anticoagulant, protein C, and promoted platelet aggregation. Higher concentrations inactivated the coagulation cascade and lysed platelets completely. These results suggest that intravariceal infusion of S.T.D. at considerable dilution may be at least as effective in inducing thrombosis as standard dosage, and possibly more so.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1619-7089
    Keywords: Diagnostic efficacy ; induced thrombi ; 111In-labelled platelets ; chacma baboon model
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The diagnostic efficiency of autologous 111In-labelled platelets (ILP) as a scanning agent in deep vein thrombosis (DVT) was investigated in 24 South African baboons (Papio ursinus). Thrombi were surgically induced by stasis, intimal injury and the injection of thrombin in the common femoral veins of adult baboons. The thrombi were allowed to age for 1, 2, 4, 8, 24, 48 and 72 h before injecting the ILP. Scanning was done with a large field gamma camera at 10 min post injection and again at 2, 4, 6, 8, 10, 14, 24, 48 and 72 h. Time-activity curves were thus obtained and it was possible to establish an optimal time after injection of the ILP to scan for each group of thrombi. The results indicate that only the younger thrombi (1–8 h after thrombus formation) were detected. Twentyfour hour and older thrombi were not visualised. A favourable time to scan in the case of the younger thrombi appeared to be approximately 20 h after the injection of ILP. However, the thrombus age limitation still impairs the diagnostic efficiency of the procedure.
    Type of Medium: Electronic Resource
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