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  • 1
    Electronic Resource
    Electronic Resource
    Proton transfer in acetonitrile: homo- and heteroassociation ^+ N-bases and trimethyl-N-oxide
    Amsterdam : Elsevier
    Electrochimica Acta 29 (1984), S. 391-395 
    Details
    ISSN: 0013-4686
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0013-4686(84)87080-2
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  • 2
    Electronic Resource
    Electronic Resource
    Potassium currents and effects of vitamin D-3 metabolites and cyclic GMP in rat osteoblastic cells
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Biomembranes 1148 (1993), S. 239-248 
    Details
    ISSN: 0005-2736
    Keywords: Osteoblast ; Potassium ion current ; Vitamin D-3 ; cyclic GMP
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0005-2736(93)90135-M
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  • 3
    Electronic Resource
    Electronic Resource
    Dual modulation of the L-type calcium current of rat osteoblastic cells by parathyroid hormone: Opposite effects of protein kinase C and cyclic nucleotides
    Amsterdam : Elsevier
    Cellular Signalling 6 (1994), S. 645-655 
    Details
    ISSN: 0898-6568
    Keywords: PKC ; Parathyroid hormone ; cAMP ; cGMP ; calcium current ; osteoblast ; vitamin D"3
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0898-6568(94)90047-7
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  • 4
    Electronic Resource
    Electronic Resource
    Concentration-dependent modulations of potassium and calcium currents of rat osteoblastic cells by arachidonic acid (1994)
    Springer
    The journal of membrane biology 138 (1994), S. 159-170 
    Details
    ISSN: 1432-1424
    Keywords: K+ current ; Ca2+ current ; Arachidonic acid ; Osteoblast
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract We show that the voltage-gated K+ and Ca2+ currents of rat osteoblastic cells are strongly modulated by arachidonic acid (AA), and that these modulations are very sensitive to the AA concentration. At 2 or 3 μm, AA reduces the amplitude and accelerates the inactivation of the K+ current activated by depolarization; at higher concentrations (≥5 μm), AA still blocks this K+ current, but also induces a very large noninactivating K+ current. At 2 or 3 μm, AA enhances the T-type Ca2+ current, close to its threshold of activation, whereas at 10 μm, it blocks that current. AA (1–10 μm) also blocks the dihydropyridine-sensitive L-type Ca2+ current. Thus, the effect of AA on Ca2+ entry through voltage-gated Ca2+ channels can change qualitatively with the AA concentration: at 2 or 3 μm, AA will favor Ca2+ entry through T channels, both by lowering the voltage-gated K+ conductance and by increasing the T current, whereas at 10 μm, AA will prevent Ca2+ entry through voltage-gated Ca2+ channels, both by inducing a K+ conductance and by blocking Ca2+ channels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00232644
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  • 5
    Electronic Resource
    Electronic Resource
    Activation by hyperpolarization and atypical osmosensitivity of a Cl− current in rat osteoblastic cells (1994)
    Springer
    The journal of membrane biology 140 (1994), S. 173-188 
    Details
    ISSN: 1432-1424
    Keywords: Cl− current ; Hyperpolarization-activated ; Osmosensitivity ; Mechanosensitivity ; Osteoblast
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract During whole-cell recording of rat osteoblastic cells with high-Cl− internal solutions, 10 sec hyperpolarizing jumps from 0 mV induce a slow inward current relaxation, which is shown to be carried by hyperpolarization-activated Cl− channels. This relaxation increases and becomes faster with stronger hyperpolarizations. It is insensitive to Cs+ ions but is blocked in a voltage-dependent manner by 4,4′-diisothiocyanatostilbene-2, 2′-disulfonic acid (DIDS) 1 mm and is reduced by 5-nitro-2-(3-phenylpropylamino) benzoic acid (NPPB) 0.1 mm. Cd2+ ions are potent blockers of this current, blocking completely above 300 μm. The amplitude of the Cl− current activated by a given hyperpolarization increases during the first 10–20 min of whole-cell recording. This evolution and the fact that some recently cloned Cl− channels have been reported to be activated both by hyperpolarization and by external hyposmolarity led us to investigate the effects of external osmolarity. Reducing the external osmolarity induces a large Cl− current. However, this hyposmolarity-induced Cl− current and the hyperpolarization-activated Cl− current are shown to be distinct; 1,9-dideoxy forskolin selectively blocks the hyposmolarity-activated current. We show that the hyperpolarization-activated Cl− current is osmosensitive, but in an unusual way: it is reduced by external hyposmolarity and is increased by external hyperosmolarity. Furthermore, these modulations are more pronounced for small hyperpolarizations. The osmosensitivity of the hyperpolarization-activated Cl− current suggests a mechanosensitivity (activation by positive external pressure) that is likely to be physiologically important to bone cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00233706
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  • 6
    Electronic Resource
    Electronic Resource
    Proton polarizability of hydrogen-bonded chains: An ab initio SCF calculation with a model related to the conducting system in bacteriorhodopsin
    Amsterdam : Elsevier
    Chemical Physics Letters 107 (1984), S. 65-69 
    Details
    ISSN: 0009-2614
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0009-2614(84)85357-9
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  • 7
    Electronic Resource
    Electronic Resource
    Cumulus dynamics: Local compensating subsidence and its implications for cumulus parameterization (1975)
    Springer
    Pure and applied geophysics 113 (1975), S. 851-867 
    Details
    ISSN: 1420-9136
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract Observations of air flow in and around convective clouds are summarized and discussed in light of the requirements for parameterization of midlatitude convection. Both theory and observation indicate that a substantial portion of the compensating subsidence occurs as dry downdrafts in the immediate vicinity of convective clouds, which suggests that an additional physical mechanism is necessary in linking convection to the large scale. A conceptual three-dimensional model of midlatitude organized convection along with its implications for parameterization, particularly in mesoscale modeling, is presented. The effects of moist downdrafts are also considered and some differences between midlatitude and tropical convection are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01592963
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  • 8
    Electronic Resource
    Electronic Resource
    Gas and fluid venting at the Makran accretionary wedge off Pakistan (2000)
    Springer
    Geo-marine letters 20 (2000), S. 10-19 
    Details
    ISSN: 1432-1157
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract The Makran accretionary complex shows a distinct bottom-simulating reflector, indicating a thick gas-hydrate-bearing horizon between the deformational front and about 1350 m water depth which seals off the upward flow of gas-charged fluids. A field of presently inactive mud diapirs with elevations up to 65 m was discovered in the abyssal plain seawards of the deformation front, suggesting that in the past conditions were favorable for periodic but localized vigorous mud diapirism. Regional destabilization of the gas hydrate leading to focused flow was observed where deep-penetrating, active faults reach the base of the gas-hydrate layer, as in a deeply incised submarine canyon (2100–2500 m water depth). At this location we discovered seeps of methane and H2S-rich fluids associated with chemoautotrophic vent faunas (e.g., Calyptogena sp.). Driven by the accretionary wedge dynamics, the landward part of the gas-hydrate layer below the Makran margin is being progressively uplifted. Due to reduced hydrostatic pressure and rising ocean bottom-water temperatures, gas hydrates are progressively destabilized and dissociated into hydrate water, methane and H2S. Sediment temperatures lie outside the methane stability field wherever water depth is less than 800 m. Above this depth, upward migration of fluids to the seafloor is unimpeded, thus explaining the abundance of randomly distributed gas seeps observed at water depths of 350 to 800 m.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003670000033
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  • 9
    Electronic Resource
    Electronic Resource
    Two-stage endoscopic removal of a foreign body from the common bile duct (1991)
    Springer
    Surgical endoscopy and other interventional techniques 5 (1991), S. 94-95 
    Details
    ISSN: 1432-2218
    Keywords: Foreign body ; Common bile duct ; Endoscopy ; Sphincterotomy ; Endoprosthesis ; Ampullary adenocarcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We describe the application of a new two-stage endoscopic procedure for removal of a retained stent in the common bile duct (Type 1 foreign body in Ban's classification). The technique involves sphincterotomy and placement of the endoprosthesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00316846
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  • 10
    Electronic Resource
    Electronic Resource
    Endoscopic treatment by snare electrocoagulation prior to Nd:YAG laser photocoagulation in 85 voluminous colorectal villous adenomas (1991)
    Springer
    Diseases of the colon & rectum 34 (1991), S. 372-377 
    Details
    ISSN: 1530-0358
    Keywords: Villous adenomas ; Colonic adenomas ; Laser ; Colonoscopy ; Polypectomy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The association of endoscopic resection with Nd:YAG laser photocoagulation was used to treat benign colorectal villous adenomas. Eighty-five patients were included: 49 with surgical contraindications, 35 for whom surgical resection appeared to be too hazardous, and 1 who refused surgery. Forty-five tumors had an axial extension between 1 and 3 cm, and 40 tumors had an axial extension of at least 4 cm. Diathermic snare resection was performed to remove large tumoral fragments prior to laser photocoagulation of the residual flat lesions. Treatments were repeated every 15 days until total tumor destruction was achieved. A carcinoma was detected in biopsy specimens obtained during endoscopic treatment of five patients. Two patients were lost to follow-up. Treatment results could be analyzed in 78 patients. Successful treatment was achieved in 67 patients. Tumor destruction was complete in 77 percent of patients who had lesions of at least 4 cm diameter and in 93 percent of patients with smaller lesions. The axial extension of the tumor was the main factor affecting the results of treatment. No major complications occurred. During the average 103-week follow-up period, 21 percent of the patients with total tumor destruction had a recurrence. The risk of recurrence was correlated with the number of initial treatment sessions and previous surgery treatment. It would appear that the treatment with endoscopic resection prior to Nd:YAG laser photocoagulation is a safe and effective method in the destruction of colorectal villous adenomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02053686
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