ISSN:
1600-0536
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
In a patient with contact dermatitis, dexpanthenol was found to be the causative allergen. There was a positive reaction to dexpanthenol on patch testing. Controls did not show any positive reactions to dexpanthenol on patch testing. Additionally, an LTT was performed, Alter pre-incubation with dexpanthenoi-modified microsomes. we observed an increase in lymphocyte proliferation to dexpamhenol, in comparison to dexpamhenol without microsomes. suggesting that microsomes metabolism plays a role in the pathogenesis of dexpanthenol sensitization, because microsomes are known to posses drug metabolizing enzymes such as cytochrome P450.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1600-0536.1993.tb03346.x
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